Human Gene OPRD1 (ENST00000234961.7_4) from GENCODE V47lift37

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Description: opioid receptor delta 1 (from RefSeq NM_000911.4)
Gencode Transcript: ENST00000234961.7_4
Gencode Gene: ENSG00000116329.12_8
Transcript (Including UTRs)
Position: hg19 chr1:29,138,682-29,197,779 Size: 59,098 Total Exon Count: 3 Strand: +
Coding Region
Position: hg19 chr1:29,138,896-29,189,795 Size: 50,900 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:29,138,682-29,197,779)			mRNA (may differ from genome)		Protein (372 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Human Cortex Gene Expression	Malacards	MGI	OMIM	PubMed
Reactome	UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: OPRD_HUMAN DESCRIPTION: RecName: Full=Delta-type opioid receptor; Short=D-OR-1; Short=DOR-1; FUNCTION: Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Highly stereoselective. receptor for enkephalins. SUBUNIT: Interacts with GPRASP1. INTERACTION: Q5JY77:GPRASP1; NbExp=2; IntAct=EBI-2624456, EBI-2514717; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. WEB RESOURCE: Name=Wikipedia; Note=Delta opioid receptor entry; URL="http://en.wikipedia.org/wiki/Delta_opioid_receptor";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: OPRD1 Diseases sorted by gene-association score: heroin dependence (14), neonatal abstinence syndrome (14), morphine dependence (11), opiate dependence (9), drug dependence (9), substance dependence (8), alcohol dependence (3)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D020881 Enkephalin, D-Penicillamine (2,5)- C055382 naltrindole D002077 Butorphanol D009020 Morphine C040643 N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine D013759 Tetrahydrocannabinol D014635 Valproic Acid C060209 deltorphin II, Ala(2)- C034318 enkephalin, Ser(2), Leu(5), Thr(6)- C507634 1,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamido)hexane C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C017487 2-mercaptoacetate C507635 3,6-bis(N,N-dimethyl-2',6'-dimethyltyrosyl-1,2,3,4-tetrahydro-3-isoquinolineamidopropyl)-2(1H)-pyrazinone C108904 3-(difluoromethyl)-1-(4-methoxyphenyl)-5-(4-(methylsulfinyl)phenyl)pyrazole C088464 4-(alpha-(4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl)-N,N-diethylbenzamide C540165 9-(8-azabicyclo(3.2.1)oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide D000157 Aconitine D000535 Aluminum D000643 Ammonium Chloride C083877 BW 373U86 D001464 Barium D001564 Benzo(a)pyrene D002047 Buprenorphine D002104 Cadmium D002185 Cannabidiol D004390 Chlorpyrifos D002994 Clofibrate D003042 Cocaine D003061 Codeine D003300 Copper D003913 Dextroamphetamine D003915 Dextromethorphan D011431 Dextropropoxyphene D003917 Dextrorphan D003993 Dibutyl Phthalate D016308 Enkephalin, Leucine-2-Alanine D020875 Enkephalin, Ala(2)-MePhe(4)-Gly(5)- D004837 Epinephrine D004997 Ethinyl Estradiol D006830 Hydralazine D006853 Hydrocodone C036405 ICI 154129 D007977 Levallorphan D007981 Levorphanol D008070 Lipopolysaccharides D008274 Magnesium D008345 Manganese D008628 Mercury D008691 Methadone D008692 Methadyl Acetate C415566 N,N-diethyl-4-(phenylpiperidin-4-ylidenemethyl)benzamide D009270 Naloxone D009271 Naltrexone D009538 Nicotine D009638 Norepinephrine D010098 Oxycodone D037342 Pertussis Toxin D012701 Serotonin C111212 TRK 820 D014147 Tramadol C045444 U 69593 D015032 Zinc D015054 Zymosan C072553 benzyloxycarbonylleucyl-leucyl-leucine aldehyde C084603 cyclorphan C044130 dextrallorphan C105293 endomorphin 1 C105294 endomorphin 2 C069837 fullerene C60 C028208 metkephamid C028007 nickel monoxide C025256 nonylphenol C089032 rimonabant C523979 tapentadol

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 0.38 RPKM in Brain - Frontal Cortex (BA9) Total median expression: 1.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-125.60	214	-0.587	Picture	PostScript	Text
3' UTR	-3446.30	7984	-0.432	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR000321 - Delta_opi_rcpt
IPR017452 - GPCR_Rhodpsn_supfam
IPR001418 - Opioid_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv
PF10328 - Serpentine type 7TM GPCR chemoreceptor Srx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1OZC - Model

2IQM - Model

ModBase Predicted Comparative 3D Structure on P41143


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0004985 opioid receptor activity GO:0005515 protein binding GO:0033612 receptor serine/threonine kinase binding GO:0038046 enkephalin receptor activity GO:0042923 neuropeptide binding Biological Process: GO:0000060 protein import into nucleus, translocation GO:0006955 immune response GO:0007165 signal transduction GO:0007186 G-protein coupled receptor signaling pathway GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007218 neuropeptide signaling pathway GO:0007268 chemical synaptic transmission GO:0008344 adult locomotory behavior GO:0010629 negative regulation of gene expression GO:0019221 cytokine-mediated signaling pathway GO:0019233 sensory perception of pain GO:0032460 negative regulation of protein oligomerization GO:0032793 positive regulation of CREB transcription factor activity GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0038003 opioid receptor signaling pathway GO:0042755 eating behavior GO:0051881 regulation of mitochondrial membrane potential GO:0051924 regulation of calcium ion transport GO:0051930 regulation of sensory perception of pain GO:0071363 cellular response to growth factor stimulus GO:0071456 cellular response to hypoxia GO:0097237 cellular response to toxic substance Cellular Component: GO:0005737 cytoplasm GO:0005886 plasma membrane GO:0005887 integral component of plasma membrane GO:0016020 membrane GO:0016021 integral component of membrane GO:0031226 intrinsic component of plasma membrane GO:0031982 vesicle GO:0032590 dendrite membrane GO:0043005 neuron projection GO:0043679 axon terminus GO:0045121 membrane raft GO:0045211 postsynaptic membrane

Descriptions from all associated GenBank mRNAs


	MG986891 - Homo sapiens opioid receptor delta 1 isoform DOR-1C (OPRD1) mRNA, complete cds, alternatively spliced. MG986890 - Homo sapiens opioid receptor delta 1 isoform DOR-1B (OPRD1) mRNA, partial cds, alternatively spliced. MG986892 - Homo sapiens opioid receptor delta 1 isoform DOR-1D (OPRD1) mRNA, complete cds, alternatively spliced. U07882 - Human delta opioid receptor mRNA, complete cds. JD423181 - Sequence 404205 from Patent EP1572962. JD407208 - Sequence 388232 from Patent EP1572962. JD477941 - Sequence 458965 from Patent EP1572962. JD257200 - Sequence 238224 from Patent EP1572962. JD396306 - Sequence 377330 from Patent EP1572962. AB463986 - Synthetic construct DNA, clone: pF1KB7197, Homo sapiens OPRD1 gene for opioid receptor, delta 1, without stop codon, in Flexi system. BC111838 - Synthetic construct Homo sapiens clone IMAGE:40080841, MGC:133395 OPRD1 protein (OPRD1) mRNA, encodes complete protein. EF057065 - Homo sapiens delta opioid receptor 1 variant mRNA, complete cds. EU883570 - Homo sapiens opioid receptor delta 1 (OPRD1) mRNA, complete cds. U10504 - Human delta opiate receptor mRNA, complete cds. MG986889 - Homo sapiens opioid receptor delta 1 isoform DOR-1E (OPRD1) mRNA, partial cds, alternatively spliced. JD211035 - Sequence 192059 from Patent EP1572962. JD125209 - Sequence 106233 from Patent EP1572962. JD498501 - Sequence 479525 from Patent EP1572962. JD544108 - Sequence 525132 from Patent EP1572962. JD417475 - Sequence 398499 from Patent EP1572962. JD343679 - Sequence 324703 from Patent EP1572962. JD402966 - Sequence 383990 from Patent EP1572962. JD335425 - Sequence 316449 from Patent EP1572962. JD388489 - Sequence 369513 from Patent EP1572962. JD443023 - Sequence 424047 from Patent EP1572962. JD335426 - Sequence 316450 from Patent EP1572962. JD457215 - Sequence 438239 from Patent EP1572962. JD118535 - Sequence 99559 from Patent EP1572962. BC042916 - Homo sapiens, clone IMAGE:5802033, mRNA. JD046330 - Sequence 27354 from Patent EP1572962. JD345365 - Sequence 326389 from Patent EP1572962. JD046195 - Sequence 27219 from Patent EP1572962. JD049857 - Sequence 30881 from Patent EP1572962. JD219463 - Sequence 200487 from Patent EP1572962. JD056570 - Sequence 37594 from Patent EP1572962. JD180364 - Sequence 161388 from Patent EP1572962. JD276093 - Sequence 257117 from Patent EP1572962. JD388079 - Sequence 369103 from Patent EP1572962. JD119589 - Sequence 100613 from Patent EP1572962. JD156899 - Sequence 137923 from Patent EP1572962. JD269783 - Sequence 250807 from Patent EP1572962. JD103596 - Sequence 84620 from Patent EP1572962. JD178410 - Sequence 159434 from Patent EP1572962. JD204885 - Sequence 185909 from Patent EP1572962. JD340146 - Sequence 321170 from Patent EP1572962. JD178487 - Sequence 159511 from Patent EP1572962. JD503850 - Sequence 484874 from Patent EP1572962. JD442489 - Sequence 423513 from Patent EP1572962. JD537790 - Sequence 518814 from Patent EP1572962. JD373341 - Sequence 354365 from Patent EP1572962. JD358907 - Sequence 339931 from Patent EP1572962. JD208753 - Sequence 189777 from Patent EP1572962. JD168580 - Sequence 149604 from Patent EP1572962. JD204593 - Sequence 185617 from Patent EP1572962. JD452672 - Sequence 433696 from Patent EP1572962. JD063161 - Sequence 44185 from Patent EP1572962. JD177508 - Sequence 158532 from Patent EP1572962. JD268349 - Sequence 249373 from Patent EP1572962. JD422565 - Sequence 403589 from Patent EP1572962. JD242771 - Sequence 223795 from Patent EP1572962. JD331114 - Sequence 312138 from Patent EP1572962. JD435415 - Sequence 416439 from Patent EP1572962. JD113973 - Sequence 94997 from Patent EP1572962. JD092475 - Sequence 73499 from Patent EP1572962. JD233692 - Sequence 214716 from Patent EP1572962. JD259727 - Sequence 240751 from Patent EP1572962. JD355249 - Sequence 336273 from Patent EP1572962. JD089666 - Sequence 70690 from Patent EP1572962. JD112929 - Sequence 93953 from Patent EP1572962. JD188435 - Sequence 169459 from Patent EP1572962. JD270387 - Sequence 251411 from Patent EP1572962. JD108231 - Sequence 89255 from Patent EP1572962.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein P41143 (Reactome details) participates in the following event(s): R-HSA-374298 Opioid receptors bind opioid peptides R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-375276 Peptide ligand-binding receptors R-HSA-6785807 Interleukin-4 and 13 signaling R-HSA-418594 G alpha (i) signalling events R-HSA-373076 Class A/1 (Rhodopsin-like receptors) R-HSA-449147 Signaling by Interleukins R-HSA-388396 GPCR downstream signalling R-HSA-500792 GPCR ligand binding R-HSA-1280215 Cytokine Signaling in Immune system R-HSA-372790 Signaling by GPCR R-HSA-168256 Immune System R-HSA-162582 Signal Transduction

Other Names for This Gene


	Alternate Gene Symbols: B5B0B8, ENST00000234961.1, ENST00000234961.2, ENST00000234961.3, ENST00000234961.4, ENST00000234961.5, ENST00000234961.6, NM_000911, OPRD, OPRD_HUMAN, P41143, uc317dzv.1, uc317dzv.2 UCSC ID: ENST00000234961.7_4 RefSeq Accession: NM_000911.4 Protein: P41143 (aka OPRD_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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