Human Gene OLIG2 (ENST00000382357.4_4) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: OLIG2_HUMAN
DESCRIPTION: RecName: Full=Oligodendrocyte transcription factor 2; Short=Oligo2; AltName: Full=Class B basic helix-loop-helix protein 1; Short=bHLHb1; AltName: Full=Class E basic helix-loop-helix protein 19; Short=bHLHe19; AltName: Full=Protein kinase C-binding protein 2; AltName: Full=Protein kinase C-binding protein RACK17;
FUNCTION: Required for oligodendrocyte and motor neuron specification in the spinal cord, as well as for the development of somatic motor neurons in the hindbrain. Cooperates with OLIG1 to establish the pMN domain of the embryonic neural tube. Antagonist of V2 interneuron and of NKX2-2-induced V3 interneuron development (By similarity).
SUBUNIT: Interacts with NKX2-2 (By similarity).
SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Note=The NLS contained in the bHLH domain could be masked in the native form and translocation to the nucleus could be mediated by interaction either with class E bHLH partner protein or with NKX2-2 (By similarity).
TISSUE SPECIFICITY: Expressed in the brain, in oligodendrocytes. Strongly expressed in oligodendrogliomas, while expression is weak to moderate in astrocytomas. Expression in glioblastomas highly variable.
INDUCTION: By SHH. Also induced by NKX6-1 in the developing spinal cord, but not in the rostral hindbrain (By similarity).
DOMAIN: The bHLH is essential for interaction with NKX2-2 (By similarity).
DISEASE: Note=A chromosomal aberration involving OLIG2 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(14;21)(q11.2;q22) with TCRA.
SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
SEQUENCE CAUTION: Sequence=AAC72247.1; Type=Erroneous initiation; Sequence=AAF61215.1; Type=Erroneous initiation;
WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/OLIG2ID236.html";
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Primer design for this transcript
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MalaCards Disease Associations
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MalaCards Gene Search: OLIG2
Diseases sorted by gene-association score: oligodendroglioma (12), lymphoblastic leukemia (7), pilocytic astrocytoma (5), astrocytoma (5), down syndrome (3), papillary glioneuronal tumor (3), brain cancer (2), childhood oligodendroglioma (2), clear cell ependymoma (1), tanycytic ependymoma (1), cerebellar liponeurocytoma (1), charcot-marie-tooth disease, type 4d (1)
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR011598 - HLH_dom
Pfam Domains:
PF00010 - Helix-loop-helix DNA-binding domain
SCOP Domains:
47459 - HLH, helix-loop-helix DNA-binding domain
ModBase Predicted Comparative 3D Structure on Q13516
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0042803 protein homodimerization activity
GO:0046983 protein dimerization activity
GO:0071837 HMG box domain binding
Biological Process:
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007275 multicellular organism development
GO:0007399 nervous system development
GO:0021522 spinal cord motor neuron differentiation
GO:0021529 spinal cord oligodendrocyte cell differentiation
GO:0021530 spinal cord oligodendrocyte cell fate specification
GO:0021778 oligodendrocyte cell fate specification
GO:0021794 thalamus development
GO:0030182 neuron differentiation
GO:0042552 myelination
GO:0045665 negative regulation of neuron differentiation
GO:0048663 neuron fate commitment
GO:0048709 oligodendrocyte differentiation
GO:0048714 positive regulation of oligodendrocyte differentiation
Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
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Descriptions from all associated GenBank mRNAs
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LF213394 - JP 2014500723-A/20897: Polycomb-Associated Non-Coding RNAs.
BC047511 - Homo sapiens oligodendrocyte lineage transcription factor 2, mRNA (cDNA clone MGC:51023 IMAGE:5300879), complete cds.
AK091462 - Homo sapiens cDNA FLJ34143 fis, clone FCBBF3011570, highly similar to Oligodendrocyte transcription factor 2.
BC036245 - Homo sapiens oligodendrocyte lineage transcription factor 2, mRNA (cDNA clone MGC:39835 IMAGE:5303546), complete cds.
BC034681 - Homo sapiens oligodendrocyte lineage transcription factor 2, mRNA (cDNA clone IMAGE:4214822), partial cds.
BC036275 - Homo sapiens oligodendrocyte lineage transcription factor 2, mRNA (cDNA clone IMAGE:4179760).
AF221520 - Homo sapiens basic helix-loop-helix protein class B 1 (BHLHB1) mRNA, partial cds.
U48250 - Human protein kinase C-binding protein RACK17 mRNA, partial cds.
JD544054 - Sequence 525078 from Patent EP1572962.
JD119582 - Sequence 100606 from Patent EP1572962.
JD527725 - Sequence 508749 from Patent EP1572962.
JD472997 - Sequence 454021 from Patent EP1572962.
JD223195 - Sequence 204219 from Patent EP1572962.
JD086212 - Sequence 67236 from Patent EP1572962.
JD544105 - Sequence 525129 from Patent EP1572962.
JD195525 - Sequence 176549 from Patent EP1572962.
JD403157 - Sequence 384181 from Patent EP1572962.
JD254157 - Sequence 235181 from Patent EP1572962.
JD063406 - Sequence 44430 from Patent EP1572962.
JD294796 - Sequence 275820 from Patent EP1572962.
JD450202 - Sequence 431226 from Patent EP1572962.
JD459335 - Sequence 440359 from Patent EP1572962.
MA448971 - JP 2018138019-A/20897: Polycomb-Associated Non-Coding RNAs.
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Other Names for This Gene
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Alternate Gene Symbols: B3KRF3, BHLHB1, BHLHE19, ENST00000382357.1, ENST00000382357.2, ENST00000382357.3, NM_005806, OLIG2_HUMAN, PRKCBP2, Q05BP9, Q13516, Q49AL3, Q86X04, Q9NZ14, RACK17, uc318quh.1, uc318quh.2
UCSC ID: ENST00000382357.4_4
RefSeq Accession: NM_005806.4
Protein: Q13516
(aka OLIG2_HUMAN or OLG2_HUMAN)
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Gene Model Information
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for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.
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US Server
