Human Gene ODC1 (ENST00000234111.9_8) from GENCODE V47lift37

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Description: ornithine decarboxylase 1, transcript variant 1 (from RefSeq NM_002539.3)
Gencode Transcript: ENST00000234111.9_8
Gencode Gene: ENSG00000115758.14_15
Transcript (Including UTRs)
Position: hg19 chr2:10,580,094-10,588,453 Size: 8,360 Total Exon Count: 12 Strand: -
Coding Region
Position: hg19 chr2:10,580,850-10,585,158 Size: 4,309 Coding Exon Count: 10

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	GeneReviews	Model Information
Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:10,580,094-10,588,453)			mRNA (may differ from genome)		Protein (461 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: DCOR_HUMAN DESCRIPTION: RecName: Full=Ornithine decarboxylase; Short=ODC; EC=4.1.1.17; CATALYTIC ACTIVITY: L-ornithine = putrescine + CO(2). COFACTOR: Pyridoxal phosphate. ENZYME REGULATION: Inhibited by S-nitrosylation. PATHWAY: Amine and polyamine biosynthesis; putrescine biosynthesis via L-ornithine pathway; putrescine from L-ornithine: step 1/1. SUBUNIT: Homodimer. INTERACTION: O95190:OAZ2; NbExp=1; IntAct=EBI-1044287, EBI-1051861; INDUCTION: Down-regulated in response to enterovirus 71 (EV71) infection (at protein level). PTM: S-Nitrosylation inhibits the enzyme. S-Nitrosylated in vitro on 4 cysteine residues. SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/odc1/"; WEB RESOURCE: Name=Wikipedia; Note=Ornithine decarboxylase entry; URL="http://en.wikipedia.org/wiki/Ornithine_decarboxylase";

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: ODC1 Diseases sorted by gene-association score: colorectal cancer* (125), transient cerebral ischemia (26), sleeping sickness (22), esophagus carcinoma in situ (16), colon adenocarcinoma (15), kidney hypertrophy (11), atrophic gastritis (11), mesenteric vascular occlusion (11), breast adenoma (11), cerebral artery occlusion (10), skin benign neoplasm (9), skin papilloma (9), autosomal dominant nonsyndromic deafness 69 (8), trypanosomiasis (7), colorectal adenoma (7), cervical intraepithelial neoplasia (6), intestinal benign neoplasm (4), familial adenomatous polyposis (4), wallerian degeneration (3), chagas disease (3), colonic benign neoplasm (3), breast cancer (3), papilloma (2), malaria (1) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D001564 Benzo(a)pyrene D013755 Tetradecanoylphorbol Acetate C006253 pirinixic acid D015058 1-Naphthylisothiocyanate C023514 2,6-dinitrotoluene C016583 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone D000082 Acetaminophen D002945 Cisplatin D003078 Colchicine D003474 Curcumin D004051 Diethylhexyl Phthalate D004054 Diethylstilbestrol D004958 Estradiol D004997 Ethinyl Estradiol D006861 Hydrogen Peroxide D015474 Isotretinoin D009151 Mustard Gas D010634 Phenobarbital D010936 Plant Extracts D011433 Propranolol D011700 Putrescine D012110 Reserpine D012402 Rotenone D013095 Spermidine D013096 Spermine D013749 Tetrachlorodibenzodioxin D013974 Thyroxine D014635 Valproic Acid D014810 Vitamin E C095105 bexarotene C006780 bisphenol A C107676 deguelin C059514 resveratrol C012589 trichostatin A C049325 1,2-dithiol-3-thione D015655 1-Methyl-4-phenylpyridinium C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl C404910 2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane D015084 2,4-Dichlorophenoxyacetic Acid C016403 2,4-dinitrotoluene C010925 2,5-dihydroxybenzoic acid C014632 2-keto-4-methylthiobutyric acid C049826 2-methoxyacetaldehyde C019499 2-nitrofluorene C041525 3,3',4,5'-tetrahydroxystilbene C472791 3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid C000433 3-chloroperbenzoic acid D012368 4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone C035207 4-amino-2,6-dinitrotoluene C002202 4-oxoretinoic acid D000079 Acetaldehyde D000117 Acetylglucosamine D016604 Aflatoxin B1 D000526 Alprenolol D000643 Ammonium Chloride D001058 Apomorphine D001241 Aspirin D001585 Benzoyl Peroxide D001599 Berberine D003994 Bucladesine D019328 Buthionine Sulfoximine D020148 Butyric Acid C031662 CB 3717 C099555 CD 437 D019256 Cadmium Chloride D002117 Calcitriol D002251 Carbon Tetrachloride D002392 Catechin D002713 Chlorine D002725 Chloroform D002772 Cholera Toxin D002794 Choline D002976 Clenbuterol D002992 Clofenapate D002994 Clofibrate D002995 Clofibric Acid D003022 Clotrimazole D003300 Copper D019327 Copper Sulfate D003436 Croton Oil D003520 Cyclophosphamide D016572 Cyclosporine D003907 Dexamethasone D003975 Diazepam D003993 Dibutyl Phthalate D004026 Dieldrin D004052 Diethylnitrosamine D004128 Dimethylnitrosamine D004237 Diuron D004317 Doxorubicin D004391 Dust D000431 Ethanol D015946 Ethylene Dibromide D005419 Flavonoids D005472 Fluorouracil D005485 Flutamide D005492 Folic Acid D005557 Formaldehyde D005707 Gallic Acid D005978 Glutathione D047348 Hydrolyzable Tannins D007487 Ipodate D007501 Iron D019266 Iron, Dietary D007505 Iron-Dextran Complex D007545 Isoproterenol C098607 JP8 aviation fuel D001556 Lindane D008070 Lipopolysaccharides D058185 Magnetite Nanoparticles D008701 Methapyrilene D008714 Methiocarb D008715 Methionine D008727 Methotrexate D008731 Methoxychlor D008769 Methylnitronitrosoguanidine D008790 Metoprolol D015741 Metribolone D008917 Mirex C059685 N(1),N(11)-diethylnorspermine C064769 N-acetylsphingosine C101954 N-caproylsphingosine D009637 Nordihydroguaiaretic Acid D009638 Norepinephrine D010100 Oxygen D010126 Ozone D010269 Paraquat D010365 Patulin D010418 Pentagastrin D010421 Pentanoic Acids D010424 Pentobarbital D010862 Pilocarpine D010882 Piperonyl Butoxide D028321 Plant Preparations D011034 Podophyllotoxin D011193 Potassium Iodide D044945 Proanthocyanidins D011374 Progesterone D011441 Propylthiouracil D011458 Prostaglandins E D011794 Quercetin D019257 Quinpirole D017382 Reactive Oxygen Species D012822 Silicon Dioxide D012839 Simazine D018038 Sodium Selenite D012999 Soman D004113 Succimer D012460 Sulfasalazine D013629 Tamoxifen D013713 Teniposide D013726 Terbutaline D013739 Testosterone D043343 Testosterone Propionate D013752 Tetracycline D014204 Trenbolone Acetate D014212 Tretinoin D014241 Trichloroethylene D014303 Trinitrotoluene D014425 Turpentine D014520 Urethane D014747 Vinblastine D024483 Vitamin K 3 C519396 aleppo tannin C103303 alitretinoin C038491 allyl sulfide C023650 aniline C006632 arsenic trioxide C015001 arsenite C028559 bathocuproine sulfonate C487081 belinostat C061022 bullatacin C007164 cumene hydroperoxide C100089 cycloartenol C017180 decamethrin C111570 di-tert-butyl peroxide C061481 dibenzoylmethane C020735 dibutyldichlorotin C037517 dicumyl peroxide C472511 dimethylarsinous acid C045651 epigallocatechin gallate C074283 estradiol 3-benzoate C033789 fenarimol C087876 fenazaquin C020326 ferric nitrilotriacetate C030544 formic acid C473894 fujiflavone P40 C069837 fullerene C60 C070081 fulvestrant C039281 furan C097613 imatinib C075954 indolo(3,2-b)carbazole C013099 mancozeb C054938 methoctramine C005219 methyl cellosolve C050296 metsulfuron methyl C011309 mezerein C017096 n-butoxyethanol C028007 nickel monoxide C029938 nickel sulfate C014707 nitrosobenzylmethylamine C023036 perfluorooctanoic acid C011272 perfosfamide C032208 perilla alcohol C045362 prochloraz C035988 procymidone C045950 propiconazole C428725 pyridaben C020972 pyrrolidine dithiocarbamic acid C025462 sulindac sulfide C061133 tamibarotene D020122 tert-Butylhydroperoxide C501413 tesaglitazar C001996 thermozymocidin C113106 tocopheryloxybutyric acid C015559 trimellitic anhydride C057693 troglitazone C025643 vinclozolin C016837 zinc chloride

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 120.33 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 1269.64 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-152.50	334	-0.457	Picture	PostScript	Text
3' UTR	-237.10	756	-0.314	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR009006 - Ala_racemase/Decarboxylase_C
IPR022643 - De-COase2_C
IPR022657 - De-COase2_CS
IPR022644 - De-COase2_N
IPR022653 - De-COase2_pyr-phos_BS
IPR000183 - Orn/DAP/Arg_de-COase
IPR002433 - Orn_de-COase

Pfam Domains:
PF00278 - Pyridoxal-dependent decarboxylase, C-terminal sheet domain
PF02784 - Pyridoxal-dependent decarboxylase, pyridoxal binding domain

SCOP Domains:
50621 - Alanine racemase C-terminal domain-like
51658 - Xylose isomerase-like
51366 - Ribulose-phoshate binding barrel
51412 - Inosine monophosphate dehydrogenase (IMPDH)
51419 - PLP-binding barrel

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1D7K - X-ray MuPIT

2ON3 - X-ray MuPIT

2OO0 - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on P11926


Front	Top	Side

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Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003824 catalytic activity GO:0004586 ornithine decarboxylase activity GO:0005515 protein binding GO:0016829 lyase activity GO:0016831 carboxy-lyase activity GO:0042803 protein homodimerization activity Biological Process: GO:0001822 kidney development GO:0006521 regulation of cellular amino acid metabolic process GO:0006595 polyamine metabolic process GO:0006596 polyamine biosynthetic process GO:0008284 positive regulation of cell proliferation GO:0009446 putrescine biosynthetic process GO:0009615 response to virus GO:0033387 putrescine biosynthetic process from ornithine GO:0042176 regulation of protein catabolic process Cellular Component: GO:0005575 cellular_component GO:0005737 cytoplasm GO:0005829 cytosol GO:0048471 perinuclear region of cytoplasm

Descriptions from all associated GenBank mRNAs


	BC028476 - Homo sapiens cDNA clone IMAGE:4040409, ** WARNING: chimeric clone **. E05957 - cDNA encoding ornithine decarboxylase. M16650 - Homo sapiens ornithine decarboxylase (ODC1) mRNA, complete cds. M20372 - Human ornithine decarboxylase (ODC) mRNA, 3' end. X55362 - Human odc1 mRNA for ornithine decarboxylase. BC014562 - Homo sapiens cDNA clone IMAGE:3505599, containing frame-shift errors. BC025296 - Homo sapiens ornithine decarboxylase 1, mRNA (cDNA clone MGC:39254 IMAGE:5088190), complete cds. AK301956 - Homo sapiens cDNA FLJ51371 complete cds, highly similar to Ornithine decarboxylase (EC 4.1.1.17). AK292352 - Homo sapiens cDNA FLJ78294 complete cds, highly similar to Homo sapiens ornithine decarboxylase 1 (ODC1), mRNA. AK312766 - Homo sapiens cDNA, FLJ93177, Homo sapiens ornithine decarboxylase 1 (ODC1), mRNA. EU176390 - Synthetic construct Homo sapiens clone IMAGE:100006489; FLH190048.01X; RZPDo839B02252D ornithine decarboxylase 1 (ODC1) gene, encodes complete protein. EU831615 - Synthetic construct Homo sapiens clone HAIB:100066644; DKFZo007C1219 ornithine decarboxylase 1 protein (ODC1) gene, encodes complete protein. DQ896069 - Synthetic construct Homo sapiens clone IMAGE:100010529; FLH190041.01L; RZPDo839D1165D ornithine decarboxylase 1 (ODC1) gene, encodes complete protein. EU831702 - Synthetic construct Homo sapiens clone HAIB:100066731; DKFZo003C1220 ornithine decarboxylase 1 protein (ODC1) gene, encodes complete protein. DQ185043 - Homo sapiens ornithine decarboxylase 1 mRNA, partial cds. CU692964 - Synthetic construct Homo sapiens gateway clone IMAGE:100022009 5' read ODC1 mRNA. X53271 - H.sapiens mRNA for ornithine decarboxylase. D28365 - Homo sapiens mRNA for ornithine decarboxylase, 5'UTR region. AB362578 - Homo sapiens ODC1 mRNA for ornithine decarboxylase 1, 5' UTR, partial sequence, splicing variant 1. JD184133 - Sequence 165157 from Patent EP1572962. JD525715 - Sequence 506739 from Patent EP1572962. JD156913 - Sequence 137937 from Patent EP1572962. JD151238 - Sequence 132262 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-46 - putrescine biosynthesis III Reactome (by CSHL, EBI, and GO) Protein P11926 (Reactome details) participates in the following event(s): R-HSA-350567 Antizyme OAZ binds to Ornithine decarboxylase R-HSA-350578 NQO1 interaction with ODC R-HSA-350600 Antizyme inhibitor binds to OAZ and stablizes ODC complex R-HSA-70692 ornithine => putrescine + CO2 R-HSA-350562 Regulation of ornithine decarboxylase (ODC) R-HSA-351202 Metabolism of polyamines R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-1430728 Metabolism

Other Names for This Gene


	Alternate Gene Symbols: DCOR_HUMAN, ENST00000234111.1, ENST00000234111.2, ENST00000234111.3, ENST00000234111.4, ENST00000234111.5, ENST00000234111.6, ENST00000234111.7, ENST00000234111.8, NM_002539, P11926, Q53TU3, Q6LDS9, uc317dyn.1, uc317dyn.2 UCSC ID: ENST00000234111.9_8 RefSeq Accession: NM_002539.3 Protein: P11926 (aka DCOR_HUMAN)

GeneReviews for This Gene


	GeneReviews article(s) related to gene ODC1: bachmann-bupp (Bachmann-Bupp Syndrome)

Gene Model Information


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Methods, Credits, and Use Restrictions


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