ID:PO210_HUMAN DESCRIPTION: RecName: Full=Nuclear pore membrane glycoprotein 210; Short=Nuclear pore protein gp210; AltName: Full=Nuclear envelope pore membrane protein POM 210; Short=POM210; AltName: Full=Nucleoporin Nup210; AltName: Full=Pore membrane protein of 210 kDa; Flags: Precursor; FUNCTION: Nucleoporin essential for nuclear pore assembly and fusion, nuclear pore spacing, as well as structural integrity. SUBUNIT: Forms dimers and possibly higher-order oligomers (By similarity). SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Ubiquitous expression, with highest levels in lung, liver, pancreas, testis, and ovary, intermediate levels in brain, kidney, and spleen, and lowest levels in heart and skeletal muscle. PTM: N-glycosylated, but not all potential glycosylation sites may be used. Contains high-mannose type oligosaccharides (By similarity). PTM: Phosphorylated at Ser-1881 in mitosis specifically; not phosphorylated in interphase (By similarity). MISCELLANEOUS: Recognized by antinuclear autoantibodies in primary biliary cirrhosis. MISCELLANEOUS: Knockdown of NUP210 causes nuclear membranes to accumulate aberrant structures termed twinned and fusion-arrested membranes and nuclear pore complex to cluster. Induces cell death and chromatin disruptions. SIMILARITY: Belongs to the NUP210 family. SEQUENCE CAUTION: Sequence=BAB15332.1; Type=Erroneous initiation; Sequence=BAC11688.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TEM1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
