Human Gene NUP153 (ENST00000262077.3_12) from GENCODE V47lift37
  Description: nucleoporin 153, transcript variant 2 (from RefSeq NM_005124.4)
Gencode Transcript: ENST00000262077.3_12
Gencode Gene: ENSG00000124789.12_13
Transcript (Including UTRs)
   Position: hg19 chr6:17,615,268-17,707,156 Size: 91,889 Total Exon Count: 22 Strand: -
Coding Region
   Position: hg19 chr6:17,616,328-17,706,618 Size: 90,291 Coding Exon Count: 22 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:17,615,268-17,707,156)mRNA (may differ from genome)Protein (1475 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NU153_HUMAN
DESCRIPTION: RecName: Full=Nuclear pore complex protein Nup153; AltName: Full=153 kDa nucleoporin; AltName: Full=Nucleoporin Nup153;
FUNCTION: Possible DNA-binding subunit of the nuclear pore complex (NPC). The repeat-containing domain may be involved in anchoring components of the pore complex to the pore membrane.
SUBUNIT: Interacts with SENP2 and XPO5. Interacts with HIV-1 integrase; this interaction might play a role in nuclear import of HIV pre-integration complex. Interacts with hepatitis B virus capsid protein; this interaction probably plays a role in nuclear import of HBV genome. Interacts with C11orf73/Hikeshi.
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Note=Located to the terminal ring structure of the nucleoplasmic cage. Tightly associated with the nuclear membrane and lamina (By similarity).
DOMAIN: Contains F-X-F-G repeats.
SIMILARITY: Contains 4 RanBP2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NUP153
Diseases sorted by gene-association score: hiv-1 (3)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • D000082 Acetaminophen
  • C111118 2',3,3',4',5-pentachloro-4-hydroxybiphenyl
  • C016403 2,4-dinitrotoluene
  • C023514 2,6-dinitrotoluene
  • C093973 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
  • C085911 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
  • C035207 4-amino-2,6-dinitrotoluene
  • D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
  • D016604 Aflatoxin B1
  • D000643 Ammonium Chloride
          more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 31.93 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 509.65 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -279.30538-0.519 Picture PostScript Text
3' UTR -244.601060-0.231 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026054 - Nucleoporin
IPR013913 - Nucleoporin_Nup153
IPR018892 - Retro-transposon_transp_CS
IPR001876 - Znf_RanBP2

Pfam Domains:
PF00641 - Zn-finger in Ran binding protein and others
PF08604 - Nucleoporin Nup153-like
PF10599 - Retro-transposon transporting motif

SCOP Domains:
48695 - Multiheme cytochromes
90209 - Ran binding protein zinc finger-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2EBQ - NMR MuPIT 2EBR - NMR MuPIT 2EBV - NMR MuPIT 2GQE - NMR MuPIT


ModBase Predicted Comparative 3D Structure on P49790
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008139 nuclear localization sequence binding
GO:0017056 structural constituent of nuclear pore
GO:0042802 identical protein binding
GO:0043495 protein anchor
GO:0046872 metal ion binding

Biological Process:
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0015031 protein transport
GO:0016032 viral process
GO:0046718 viral entry into host cell
GO:0046832 negative regulation of RNA export from nucleus
GO:0051028 mRNA transport
GO:0051292 nuclear pore complex assembly
GO:0075732 viral penetration into host nucleus

Cellular Component:
GO:0005634 nucleus
GO:0005643 nuclear pore
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0034399 nuclear periphery
GO:0042405 nuclear inclusion body
GO:0043657 host cell
GO:0044615 nuclear pore nuclear basket
GO:0044613 nuclear pore central transport channel


-  Descriptions from all associated GenBank mRNAs
  BC052965 - Homo sapiens nucleoporin 153kDa, mRNA (cDNA clone MGC:51910 IMAGE:6067006), complete cds.
Z25535 - H.sapiens mRNA for nuclear pore complex protein hnup153.
AB210024 - Homo sapiens mRNA for NUP153 variant protein, clone: ha04696.
AK295644 - Homo sapiens cDNA FLJ60565 complete cds, highly similar to Nuclear pore complex protein Nup153.
AB384675 - Synthetic construct DNA, clone: pF1KB0045, Homo sapiens NUP153 gene for nucleoporin 153kDa, complete cds, without stop codon, in Flexi system.
JD237232 - Sequence 218256 from Patent EP1572962.
JD432826 - Sequence 413850 from Patent EP1572962.
JD530959 - Sequence 511983 from Patent EP1572962.
JD495183 - Sequence 476207 from Patent EP1572962.
JD469579 - Sequence 450603 from Patent EP1572962.
JD466928 - Sequence 447952 from Patent EP1572962.
JD555573 - Sequence 536597 from Patent EP1572962.
JD422502 - Sequence 403526 from Patent EP1572962.
JD369437 - Sequence 350461 from Patent EP1572962.
JD466819 - Sequence 447843 from Patent EP1572962.
JD039265 - Sequence 20289 from Patent EP1572962.
JD507199 - Sequence 488223 from Patent EP1572962.
DD356920 - Method of Screening for Compound Regulating Translation of Specific mRNA.
JD555897 - Sequence 536921 from Patent EP1572962.
JD185147 - Sequence 166171 from Patent EP1572962.
JD255299 - Sequence 236323 from Patent EP1572962.
JD520460 - Sequence 501484 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCarta from NCI Cancer Genome Anatomy Project
h_npcPathway - Mechanism of Protein Import into the Nucleus

Reactome (by CSHL, EBI, and GO)

Protein P49790 (Reactome details) participates in the following event(s):

R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
R-HSA-180622 Vpr binds nucleoporins
R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm
R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm
R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus
R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2
R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1
R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2
R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1
R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3
R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1
R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1
R-HSA-192627 Viral mRNA Export
R-HSA-192925 Export of Spliced Viral mRNA
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-180746 Nuclear import of Rev protein
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162587 HIV Life Cycle
R-HSA-162909 Host Interactions of HIV factors
R-HSA-68875 Mitotic Prophase
R-HSA-70171 Glycolysis
R-HSA-168253 Host Interactions with Influenza Factors
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-211000 Gene Silencing by RNA
R-HSA-72306 tRNA processing
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953854 Metabolism of RNA
R-HSA-162906 HIV Infection
R-HSA-68886 M Phase
R-HSA-70326 Glucose metabolism
R-HSA-168254 Influenza Infection
R-HSA-913531 Interferon Signaling
R-HSA-74160 Gene expression (Transcription)
R-HSA-2990846 SUMOylation
R-HSA-168255 Influenza Life Cycle
R-HSA-2262752 Cellular responses to stress
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-597592 Post-translational protein modification
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B4DIK2, E7EPX5, ENST00000262077.1, ENST00000262077.2, F6QR24, NM_005124, NU153_HUMAN, P49790, Q4LE47, Q5T9I7, Q7Z743, uc317gwo.1, uc317gwo.2
UCSC ID: ENST00000262077.3_12
RefSeq Accession: NM_005124.4
Protein: P49790 (aka NU153_HUMAN or N153_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.