ID:NSL1_HUMAN DESCRIPTION: RecName: Full=Kinetochore-associated protein NSL1 homolog; FUNCTION: Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. SUBUNIT: Component of the MIS12 complex composed of MIS12, DSN1, NSL1/DC8 and PMF1. Interacts with CASC5. SUBCELLULAR LOCATION: Nucleus. Chromosome, centromere, kinetochore. Note=Associated with the kinetochore. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE CAUTION: Sequence=AAF86877.1; Type=Frameshift; Positions=41;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF08641 - Kinetochore protein Mis14 like
ModBase Predicted Comparative 3D Structure on Q96IY1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
LF383673 - JP 2014500723-A/191176: Polycomb-Associated Non-Coding RNAs. AK092359 - Homo sapiens cDNA FLJ35040 fis, clone OCBBF2017055. AK124596 - Homo sapiens cDNA FLJ42605 fis, clone BRACE3012043. DQ591768 - Homo sapiens piRNA piR-58880, complete sequence. JD560738 - Sequence 541762 from Patent EP1572962. JD352345 - Sequence 333369 from Patent EP1572962. JD346372 - Sequence 327396 from Patent EP1572962. JD311889 - Sequence 292913 from Patent EP1572962. JD554462 - Sequence 535486 from Patent EP1572962. JD425902 - Sequence 406926 from Patent EP1572962. JD255762 - Sequence 236786 from Patent EP1572962. JD135012 - Sequence 116036 from Patent EP1572962. JD164384 - Sequence 145408 from Patent EP1572962. JD481345 - Sequence 462369 from Patent EP1572962. JD512688 - Sequence 493712 from Patent EP1572962. JD412734 - Sequence 393758 from Patent EP1572962. JD197778 - Sequence 178802 from Patent EP1572962. JD311787 - Sequence 292811 from Patent EP1572962. JD304116 - Sequence 285140 from Patent EP1572962. JD304114 - Sequence 285138 from Patent EP1572962. JD304115 - Sequence 285139 from Patent EP1572962. JD339100 - Sequence 320124 from Patent EP1572962. JD397047 - Sequence 378071 from Patent EP1572962. JD311784 - Sequence 292808 from Patent EP1572962. JD261009 - Sequence 242033 from Patent EP1572962. JD105090 - Sequence 86114 from Patent EP1572962. JD142460 - Sequence 123484 from Patent EP1572962. JD256540 - Sequence 237564 from Patent EP1572962. JD513918 - Sequence 494942 from Patent EP1572962. JD379668 - Sequence 360692 from Patent EP1572962. JD094116 - Sequence 75140 from Patent EP1572962. JD379667 - Sequence 360691 from Patent EP1572962. JD120558 - Sequence 101582 from Patent EP1572962. JD120559 - Sequence 101583 from Patent EP1572962. JD148683 - Sequence 129707 from Patent EP1572962. JD414809 - Sequence 395833 from Patent EP1572962. JD495785 - Sequence 476809 from Patent EP1572962. AF255793 - Homo sapiens DC31 mRNA, complete cds. AK223260 - Homo sapiens mRNA for chromosome 1 open reading frame 48 variant, clone: SYN01568. AL050084 - Homo sapiens mRNA; cDNA DKFZp566O1646 (from clone DKFZp566O1646). AF201941 - Homo sapiens DC8 (DC8) mRNA, complete cds. BC007067 - Homo sapiens NSL1, MIND kinetochore complex component, homolog (S. cerevisiae), mRNA (cDNA clone MGC:12522 IMAGE:3997280), complete cds. BC036048 - Homo sapiens, similar to DKFZP566O1646 protein, clone IMAGE:5273529, mRNA. AK222996 - Homo sapiens mRNA for chromosome 1 open reading frame 48 variant, clone: HSI10556. JD268544 - Sequence 249568 from Patent EP1572962. AK303250 - Homo sapiens cDNA FLJ54215 complete cds. JD130192 - Sequence 111216 from Patent EP1572962. JD154472 - Sequence 135496 from Patent EP1572962. AK313730 - Homo sapiens cDNA, FLJ94330. KJ898572 - Synthetic construct Homo sapiens clone ccsbBroadEn_07966 NSL1 gene, encodes complete protein. CU675531 - Synthetic construct Homo sapiens gateway clone IMAGE:100018713 5' read NSL1 mRNA. DQ892899 - Synthetic construct clone IMAGE:100005529; FLH193414.01X; RZPDo839F1278D chromosome 1 open reading frame 48 (C1orf48) gene, encodes complete protein. DQ896149 - Synthetic construct Homo sapiens clone IMAGE:100010609; FLH193410.01L; RZPDo839F1268D chromosome 1 open reading frame 48 (C1orf48) gene, encodes complete protein. AB528354 - Synthetic construct DNA, clone: pF1KB6318, Homo sapiens NSL1 gene for NSL1, MIND kinetochore complex component, homolog, without stop codon, in Flexi system. MA619250 - JP 2018138019-A/191176: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q96IY1 (Reactome details) participates in the following event(s):
R-HSA-141409 Mad1 binds kinetochore R-HSA-375302 Kinetochore capture of astral microtubules R-HSA-5666129 CDC42:GTP recruits DIAPH2-2 to kinetochores R-HSA-5666169 Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 R-HSA-141431 MAD2 associates with the Mad1 kinetochore complex R-HSA-141439 Release of activated MAD2 from kinetochores R-HSA-2467811 Separation of sister chromatids R-HSA-2467809 ESPL1 (Separase) cleaves centromeric cohesin R-HSA-5666160 AURKB phosphorylates DIAPH2-2 at kinetochores R-HSA-141422 MAD2 converted to an inhibitory state via interaction with Mad1 R-HSA-1638821 PP2A-B56 dephosphorylates centromeric cohesin R-HSA-1638803 Phosphorylation of cohesin by PLK1 at centromeres R-HSA-2468287 CDK1 phosphorylates CDCA5 (Sororin) at centromeres R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal R-HSA-68877 Mitotic Prometaphase R-HSA-5663220 RHO GTPases Activate Formins R-HSA-2500257 Resolution of Sister Chromatid Cohesion R-HSA-2467813 Separation of Sister Chromatids R-HSA-141424 Amplification of signal from the kinetochores R-HSA-68886 M Phase R-HSA-195258 RHO GTPase Effectors R-HSA-68882 Mitotic Anaphase R-HSA-69618 Mitotic Spindle Checkpoint R-HSA-69278 Cell Cycle (Mitotic) R-HSA-194315 Signaling by Rho GTPases R-HSA-2555396 Mitotic Metaphase and Anaphase R-HSA-69620 Cell Cycle Checkpoints R-HSA-1640170 Cell Cycle R-HSA-162582 Signal Transduction
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
