Human Gene NR1I3 (ENST00000367983.9_10) from GENCODE V47lift37

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Description: nuclear receptor subfamily 1 group I member 3, transcript variant 3 (from RefSeq NM_005122.5)
Gencode Transcript: ENST00000367983.9_10
Gencode Gene: ENSG00000143257.12_11
Transcript (Including UTRs)
Position: hg19 chr1:161,199,459-161,207,993 Size: 8,535 Total Exon Count: 9 Strand: -
Coding Region
Position: hg19 chr1:161,199,587-161,206,355 Size: 6,769 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:161,199,459-161,207,993)			mRNA (may differ from genome)		Protein (348 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NR1I3_HUMAN DESCRIPTION: RecName: Full=Nuclear receptor subfamily 1 group I member 3; AltName: Full=Constitutive activator of retinoid response; Short=Constitutive active response; AltName: Full=Constitutive androstane receptor; Short=CAR; AltName: Full=Orphan nuclear receptor MB67; FUNCTION: Binds and transactivates the retinoic acid response elements that control expression of the retinoic acid receptor beta 2 and alcohol dehydrogenase 3 genes. Transactivates both the phenobarbital responsive element module of the human CYP2B6 gene and the CYP3A4 xenobiotic response element. SUBUNIT: Interacts with ECT2 (By similarity). Heterodimer of NR1I3 and RXR. Interacts with PSMC4. Directly interacts with DNAJC7. The DNAJC7-NR1I3 complex may also include HSP90 (By similarity). SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton. Note=Recruited to the cytoplasm by DNAJC7 (By similarity). TISSUE SPECIFICITY: Predominantly expressed in liver. INDUCTION: By dexamethasone. DOMAIN: Composed by a short N-terminal domain followed by the DNA binding, hinge, and ligand binding/dimerization domains. PTM: Phosphorylated at Thr-38 by PKC, dephosphorylation of Thr-38 is required for nuclear translocation and activation. SIMILARITY: Belongs to the nuclear hormone receptor family. NR1 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain.

Primer design for this transcript

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Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NR1I3 Diseases sorted by gene-association score: biliary tract disease (12), hyperparathyroidism, neonatal (10), intrahepatic cholestasis (8), neonatal jaundice (8), cholestasis (8), bilirubin metabolic disorder (7), idiopathic hypercalciuria (6), acute porphyria (5), hyperparathyroidism, familial primary (4)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C028474 1,4-bis(2-(3,5-dichloropyridyloxy))benzene C475093 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime C000658 androstan-3-ol C500336 2,2',4,4',5-pentachlorobiphenyl D000737 Androstenols D003022 Clotrimazole D003633 Dichlorodiphenyl Dichloroethylene D004958 Estradiol D004970 Estrone D007093 Imidazoles more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 54.05 RPKM in Liver Total median expression: 65.34 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-50.90	196	-0.260	Picture	PostScript	Text
3' UTR	-36.60	128	-0.286	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR008946 - Nucl_hormone_rcpt_ligand-bd
IPR000536 - Nucl_hrmn_rcpt_lig-bd_core
IPR001723 - Str_hrmn_rcpt
IPR001728 - ThyrH_rcpt
IPR001628 - Znf_hrmn_rcpt
IPR013088 - Znf_NHR/GATA

Pfam Domains:
PF00104 - Ligand-binding domain of nuclear hormone receptor
PF00105 - Zinc finger, C4 type (two domains)

SCOP Domains:
48508 - Nuclear receptor ligand-binding domain
57716 - Glucocorticoid receptor-like (DNA-binding domain)

Protein Data Bank (PDB) 3-D Structure
MuPIT help

1XV9 - X-ray MuPIT

1XVP - X-ray MuPIT

ModBase Predicted Comparative 3D Structure on Q14994


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003707 steroid hormone receptor activity GO:0003713 transcription coactivator activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0004882 androgen receptor activity GO:0004887 thyroid hormone receptor activity GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006367 transcription initiation from RNA polymerase II promoter GO:0007165 signal transduction GO:0030521 androgen receptor signaling pathway GO:0030522 intracellular receptor signaling pathway GO:0043401 steroid hormone mediated signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter Cellular Component: GO:0005634 nucleus GO:0005654 nucleoplasm GO:0005737 cytoplasm GO:0005829 cytosol GO:0005856 cytoskeleton

Descriptions from all associated GenBank mRNAs


	HQ447449 - Synthetic construct Homo sapiens clone IMAGE:100070777; CCSB013990_01 nuclear receptor subfamily 1, group I, member 3 (NR1I3) gene, encodes complete protein. KJ898127 - Synthetic construct Homo sapiens clone ccsbBroadEn_07521 NR1I3 gene, encodes complete protein. KR711359 - Synthetic construct Homo sapiens clone CCSBHm_00023120 NR1I3 (NR1I3) mRNA, encodes complete protein. KR711360 - Synthetic construct Homo sapiens clone CCSBHm_00023121 NR1I3 (NR1I3) mRNA, encodes complete protein. Z30425 - H.sapiens mRNA for orphan nuclear hormone receptor. JD039112 - Sequence 20136 from Patent EP1572962. BC069626 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97209 IMAGE:7262456), complete cds. BC069651 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:97144 IMAGE:7262385), complete cds. JD379445 - Sequence 360469 from Patent EP1572962. JD434164 - Sequence 415188 from Patent EP1572962. JD541391 - Sequence 522415 from Patent EP1572962. AY572806 - Homo sapiens constitutive androstane receptor SV1 (NR1I3) mRNA, partial cds, alternatively spliced. AY572807 - Homo sapiens constitutive androstane receptor SV2 (NR1I3) mRNA, complete cds, alternatively spliced. AY572808 - Homo sapiens constitutive androstane receptor SV3 (NR1I3) mRNA, complete cds, alternatively spliced. AY572809 - Homo sapiens constitutive androstane receptor SV4 (NR1I3) mRNA, complete cds, alternatively spliced. AY572810 - Homo sapiens constitutive androstane receptor SV5 (NR1I3) mRNA, complete cds, alternatively spliced. AY572811 - Homo sapiens constitutive androstane receptor SV6 (NR1I3) mRNA, complete cds, alternatively spliced. AY572812 - Homo sapiens constitutive androstane receptor SV7 (NR1I3) mRNA, partial cds, alternatively spliced. AY572813 - Homo sapiens constitutive androstane receptor SV8 (NR1I3) mRNA, partial cds, alternatively spliced. AY572814 - Homo sapiens constitutive androstane receptor SV9 (NR1I3) mRNA, complete cds, alternatively spliced. AY572815 - Homo sapiens constitutive androstane receptor SV10 (NR1I3) mRNA, complete cds, alternatively spliced. AY572816 - Homo sapiens constitutive androstane receptor SV11 (NR1I3) mRNA, partial cds, alternatively spliced. AY572817 - Homo sapiens constitutive androstane receptor SV12 (NR1I3) mRNA, partial cds, alternatively spliced. AY572818 - Homo sapiens constitutive androstane receptor SV13 (NR1I3) mRNA, partial cds, alternatively spliced. AY572819 - Homo sapiens constitutive androstane receptor SV14 (NR1I3) mRNA, partial cds, alternatively spliced. AY572820 - Homo sapiens constitutive androstane receptor SV15 (NR1I3) mRNA, partial cds, alternatively spliced. AY572821 - Homo sapiens constitutive androstane receptor SV16 (NR1I3) mRNA, partial cds, alternatively spliced. AY572822 - Homo sapiens constitutive androstane receptor SV17 (NR1I3) mRNA, complete cds, alternatively spliced. AY572823 - Homo sapiens constitutive androstane receptor SV18 (NR1I3) mRNA, complete cds, alternatively spliced. AY572824 - Homo sapiens constitutive androstane receptor SV19 (NR1I3) mRNA, complete cds, alternatively spliced. AY572825 - Homo sapiens constitutive androstane receptor SV20 (NR1I3) mRNA, complete cds, alternatively spliced. AY572826 - Homo sapiens constitutive androstane receptor SV21 (NR1I3) mRNA, complete cds, alternatively spliced. AY572827 - Homo sapiens constitutive androstane receptor SV22 (NR1I3) mRNA, complete cds, alternatively spliced. BC121120 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150433 IMAGE:40120664), complete cds. BC121121 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone MGC:150434 IMAGE:40120665), complete cds. JD205246 - Sequence 186270 from Patent EP1572962. JD140847 - Sequence 121871 from Patent EP1572962. AB307702 - Homo sapiens NR1I3 mRNA for constitutive androstane receptor, complete cds. DQ022681 - Homo sapiens nuclear receptor subfamily 1, group I, member 3 mRNA, complete cds, alternatively spliced. HQ692838 - Homo sapiens constitutive androstane nuclear receptor variant 2 (NR1i3) mRNA, complete cds. HQ692839 - Homo sapiens constitutive androstane nuclear receptor variant 3 (NR1i3) mRNA, complete cds. HQ692840 - Homo sapiens constitutive androstane nuclear receptor variant 4 (NR1i3) mRNA, complete cds. HQ692841 - Homo sapiens constitutive androstane nuclear receptor variant 5 (NR1i3) mRNA, complete cds. HQ709178 - Homo sapiens constitutive androstane nuclear receptor (NR1I3) mRNA, complete cds. CU686946 - Synthetic construct Homo sapiens gateway clone IMAGE:100022636 5' read NR1I3 mRNA. AK303757 - Homo sapiens cDNA FLJ50348 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK310773 - Homo sapiens cDNA, FLJ17815. AK316208 - Homo sapiens cDNA, FLJ79107 complete cds, highly similar to Orphan nuclear receptor NR1I3. AK303796 - Homo sapiens cDNA FLJ56764 complete cds, highly similar to Orphan nuclear receptor NR1I3. BC030972 - Homo sapiens nuclear receptor subfamily 1, group I, member 3, mRNA (cDNA clone IMAGE:4556554), with apparent retained intron.

Biochemical and Signaling Pathways


	BioCarta from NCI Cancer Genome Anatomy Project h_nuclearRsPathway - Nuclear Receptors in Lipid Metabolism and Toxicity h_AcetaminophenPathway - Mechanism of Acetaminophen Activity and Toxicity Reactome (by CSHL, EBI, and GO) Protein Q14994 (Reactome details) participates in the following event(s): R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription)

Other Names for This Gene


	Alternate Gene Symbols: CAR, E9PB75, E9PC13, E9PDU3, E9PGH6, E9PH10, E9PHC8, E9PHN4, ENST00000367983.1, ENST00000367983.2, ENST00000367983.3, ENST00000367983.4, ENST00000367983.5, ENST00000367983.6, ENST00000367983.7, ENST00000367983.8, F1D8Q0, F1D8Q1, NM_005122, NR1I3_HUMAN, Q0VAC9, Q14994, Q4U0F0, Q5VTW5, Q5VTW6, Q6GZ68, Q6GZ76, Q6GZ77, Q6GZ78, Q6GZ79, Q6GZ82, Q6GZ83, Q6GZ84, Q6GZ85, Q6GZ87, Q6GZ89, uc318gjc.1, uc318gjc.2 UCSC ID: ENST00000367983.9_10 RefSeq Accession: NM_005122.5 Protein: Q14994 (aka NR1I3_HUMAN or NRI3_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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