Human Gene NPY2R (ENST00000329476.4_4) from GENCODE V47lift37
  Description: neuropeptide Y receptor Y2, transcript variant 3 (from RefSeq NM_001375470.1)
Gencode Transcript: ENST00000329476.4_4
Gencode Gene: ENSG00000185149.6_7
Transcript (Including UTRs)
   Position: hg19 chr4:156,129,788-156,138,228 Size: 8,441 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr4:156,135,092-156,136,237 Size: 1,146 Coding Exon Count: 1 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:156,129,788-156,138,228)mRNA (may differ from genome)Protein (381 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NPY2R_HUMAN
DESCRIPTION: RecName: Full=Neuropeptide Y receptor type 2; Short=NPY2-R; AltName: Full=NPY-Y2 receptor; Short=Y2 receptor;
FUNCTION: Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PYY > NPY > PYY (3-36) > NPY (2-36) > [Ile-31, Gln-34] PP > [Leu- 31, Pro-34] NPY > PP, [Pro-34] PYY and NPY free acid.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NPY2R
Diseases sorted by gene-association score: obesity (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 1.05 RPKM in Brain - Hypothalamus
Total median expression: 6.73 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -188.20482-0.390 Picture PostScript Text
3' UTR -423.201991-0.213 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR001358 - NPY2_rcpt
IPR000611 - NPY_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2IK3 - Model


ModBase Predicted Comparative 3D Structure on P49146
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0001601 peptide YY receptor activity
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
GO:0005246 calcium channel regulator activity
GO:0005515 protein binding
GO:0038023 signaling receptor activity

Biological Process:
GO:0001662 behavioral fear response
GO:0002793 positive regulation of peptide secretion
GO:0003151 outflow tract morphogenesis
GO:0003214 cardiac left ventricle morphogenesis
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007263 nitric oxide mediated signal transduction
GO:0007268 chemical synaptic transmission
GO:0007568 aging
GO:0007626 locomotory behavior
GO:0007631 feeding behavior
GO:0010811 positive regulation of cell-substrate adhesion
GO:0031645 negative regulation of neurological system process
GO:0033603 positive regulation of dopamine secretion
GO:0043951 negative regulation of cAMP-mediated signaling
GO:0045987 positive regulation of smooth muscle contraction
GO:0046010 positive regulation of circadian sleep/wake cycle, non-REM sleep
GO:0046903 secretion
GO:0050805 negative regulation of synaptic transmission
GO:0051048 negative regulation of secretion
GO:0051930 regulation of sensory perception of pain
GO:0051967 negative regulation of synaptic transmission, glutamatergic
GO:0090394 negative regulation of excitatory postsynaptic potential
GO:2000252 negative regulation of feeding behavior

Cellular Component:
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0097730 non-motile cilium


-  Descriptions from all associated GenBank mRNAs
  U42766 - Human neuropeptide y2 receptor mRNA, complete cds.
JD134755 - Sequence 115779 from Patent EP1572962.
JD523143 - Sequence 504167 from Patent EP1572962.
JD464298 - Sequence 445322 from Patent EP1572962.
U32500 - Human type 2 neuropeptide Y receptor mRNA, complete cds.
JD104885 - Sequence 85909 from Patent EP1572962.
JD468151 - Sequence 449175 from Patent EP1572962.
U42389 - human neuropeptide y/peptide YY receptor type 2 mRNA, complete cds.
JD330155 - Sequence 311179 from Patent EP1572962.
BC075052 - Homo sapiens neuropeptide Y receptor Y2, mRNA (cDNA clone MGC:103963 IMAGE:30915364), complete cds.
BC075053 - Homo sapiens neuropeptide Y receptor Y2, mRNA (cDNA clone MGC:104126 IMAGE:30915580), complete cds.
U36269 - Human neuropeptide Y/peptide YY Y2 receptor mRNA, complete cds.
AB464636 - Synthetic construct DNA, clone: pF1KB8817, Homo sapiens NPY2R gene for neuropeptide Y receptor Y2, without stop codon, in Flexi system.
KJ891715 - Synthetic construct Homo sapiens clone ccsbBroadEn_01109 NPY2R gene, encodes complete protein.
JD239423 - Sequence 220447 from Patent EP1572962.
JD434178 - Sequence 415202 from Patent EP1572962.
JD184379 - Sequence 165403 from Patent EP1572962.
JD314797 - Sequence 295821 from Patent EP1572962.
JD348692 - Sequence 329716 from Patent EP1572962.
JD173671 - Sequence 154695 from Patent EP1572962.
JD058045 - Sequence 39069 from Patent EP1572962.
JD501198 - Sequence 482222 from Patent EP1572962.
JD203428 - Sequence 184452 from Patent EP1572962.
JD301206 - Sequence 282230 from Patent EP1572962.
JD092194 - Sequence 73218 from Patent EP1572962.
JD292923 - Sequence 273947 from Patent EP1572962.
JD314618 - Sequence 295642 from Patent EP1572962.
JD314892 - Sequence 295916 from Patent EP1572962.
JD562999 - Sequence 544023 from Patent EP1572962.
JD224417 - Sequence 205441 from Patent EP1572962.
JD046784 - Sequence 27808 from Patent EP1572962.
JD232012 - Sequence 213036 from Patent EP1572962.
JD349800 - Sequence 330824 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P49146 (Reactome details) participates in the following event(s):

R-HSA-388863 Neuropeptide Y receptors can bind neuropeptide Y-related peptides
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000329476.1, ENST00000329476.2, ENST00000329476.3, NM_001375470, NPY2R_HUMAN, P49146, Q13281, Q13457, Q4W5G7, Q6AZZ6, Q9UE67, uc317sth.1, uc317sth.2
UCSC ID: ENST00000329476.4_4
RefSeq Accession: NM_000910.4
Protein: P49146 (aka NPY2R_HUMAN or NY2R_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.