ID:NOXA1_HUMAN DESCRIPTION: RecName: Full=NADPH oxidase activator 1; Short=NOX activator 1; AltName: Full=Antigen NY-CO-31; AltName: Full=NCF2-like protein; AltName: Full=P67phox-like factor; AltName: Full=p51-nox; FUNCTION: Functions as an activator of NOX1, a superoxide- producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3. SUBUNIT: NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interaction with YWHAZ prevents the interaction of NOXA1 with NOXO1 and RAC1 and its targeting to membranes, hence reducing its ability to activate NOX1. Interacts (via N-terminus) with SH3PXD2A and SH3PXD2B; the interaction is direct. SUBCELLULAR LOCATION: Cytoplasm. Cell membrane. Note=Translocation to membranes depends on NOXO1 or NCF1 and maybe RAC1. TISSUE SPECIFICITY: Widely expressed. Detected in pancreas, liver, kidney, spleen, prostate, small intestine and colon. DEVELOPMENTAL STAGE: Expressed in fetal kidney. DOMAIN: The SH3 domain mediates interaction with NOXO1 and NCF1 and has autoregulatory function. DOMAIN: The TPR repeats mediate interaction with RAC1. PTM: Interaction with YWHAZ depends on phosphorylation by PKA. SIMILARITY: Belongs to the NCF2/NOXA1 family. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 SH3 domain. SIMILARITY: Contains 4 TPR repeats. SEQUENCE CAUTION: Sequence=AAY16126.1; Type=Frameshift; Positions=305;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q86UR1
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006801 superoxide metabolic process GO:0010310 regulation of hydrogen peroxide metabolic process GO:0043085 positive regulation of catalytic activity GO:0060263 regulation of respiratory burst
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
