Human Gene NOMO3 (ENST00000399336.9_9) from GENCODE V47lift37
  Description: NODAL modulator 3 (from RefSeq NM_001004067.4)
Gencode Transcript: ENST00000399336.9_9
Gencode Gene: ENSG00000103226.19_14
Transcript (Including UTRs)
   Position: hg19 chr16:16,326,385-16,388,668 Size: 62,284 Total Exon Count: 31 Strand: +
Coding Region
   Position: hg19 chr16:16,326,524-16,388,156 Size: 61,633 Coding Exon Count: 31 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:16,326,385-16,388,668)mRNA (may differ from genome)Protein (1222 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NOMO3_HUMAN
DESCRIPTION: RecName: Full=Nodal modulator 3; AltName: Full=pM5 protein 3; Flags: Precursor;
FUNCTION: May antagonize Nodal signaling (By similarity).
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Potential).
CAUTION: There are 3 copies of the NOMO gene on chromosome 16p12- p13: NOMO1 (AC Q5JPE7), NOMO2 (AC Q5JPE7) and NOMO3. All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. The results reported in other entries may therefore apply for this protein.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NOMO3
Diseases sorted by gene-association score: pseudoxanthoma elasticum (4), superficial urinary bladder cancer (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 7.10 RPKM in Pancreas
Total median expression: 145.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -65.60139-0.472 Picture PostScript Text
3' UTR -163.00512-0.318 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013784 - Carb-bd-like_fold
IPR008969 - CarboxyPept-like_regulatory
IPR014766 - CarboxyPept_regulatory_dom
IPR013783 - Ig-like_fold

Pfam Domains:
PF09430 - Protein of unknown function (DUF2012)
PF13620 - Carboxypeptidase regulatory-like domain
PF17802 - Prealbumin-like fold domain

SCOP Domains:
49265 - Fibronectin type III
49452 - Starch-binding domain-like
49464 - Carboxypeptidase regulatory domain-like
49478 - Cna protein B-type domain
49482 - Aromatic compound dioxygenase
117074 - Hypothetical protein PA1324
51197 - Clavaminate synthase-like

ModBase Predicted Comparative 3D Structure on P69849
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003674 molecular_function
GO:0030246 carbohydrate binding

Biological Process:
GO:0008150 biological_process

Cellular Component:
GO:0005575 cellular_component
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AL832855 - Homo sapiens mRNA; cDNA DKFZp667N0525 (from clone DKFZp667N0525).
BC041131 - Homo sapiens NODAL modulator 2, mRNA (cDNA clone MGC:47607 IMAGE:5757234), complete cds.
AK225803 - Homo sapiens mRNA for nodal modulator 2 isoform 2 variant, clone: FCC130D11.
BC028389 - Homo sapiens NODAL modulator 2, mRNA (cDNA clone MGC:33249 IMAGE:4824724), complete cds.
AB463143 - Synthetic construct DNA, clone: pF1KB1226, Homo sapiens NOMO2 gene for NODAL modulator 2, without stop codon, in Flexi system.
BC156526 - Synthetic construct Homo sapiens clone IMAGE:100063136, MGC:190703 NODAL modulator 3 (NOMO3) mRNA, encodes complete protein.
BC006531 - Homo sapiens NODAL modulator 3, mRNA (cDNA clone IMAGE:3841946), partial cds.
KJ904286 - Synthetic construct Homo sapiens clone ccsbBroadEn_13680 NOMO3 gene, encodes complete protein.
BC013837 - Homo sapiens NODAL modulator 3, mRNA (cDNA clone IMAGE:4154260).
LF367932 - JP 2014500723-A/175435: Polycomb-Associated Non-Coding RNAs.
JD141468 - Sequence 122492 from Patent EP1572962.
LF367940 - JP 2014500723-A/175443: Polycomb-Associated Non-Coding RNAs.
LF367941 - JP 2014500723-A/175444: Polycomb-Associated Non-Coding RNAs.
LF367942 - JP 2014500723-A/175445: Polycomb-Associated Non-Coding RNAs.
LF367943 - JP 2014500723-A/175446: Polycomb-Associated Non-Coding RNAs.
LF367945 - JP 2014500723-A/175448: Polycomb-Associated Non-Coding RNAs.
LF367946 - JP 2014500723-A/175449: Polycomb-Associated Non-Coding RNAs.
LF367947 - JP 2014500723-A/175450: Polycomb-Associated Non-Coding RNAs.
LF367948 - JP 2014500723-A/175451: Polycomb-Associated Non-Coding RNAs.
LF367949 - JP 2014500723-A/175452: Polycomb-Associated Non-Coding RNAs.
LF367950 - JP 2014500723-A/175453: Polycomb-Associated Non-Coding RNAs.
LF367951 - JP 2014500723-A/175454: Polycomb-Associated Non-Coding RNAs.
LF367952 - JP 2014500723-A/175455: Polycomb-Associated Non-Coding RNAs.
LF367953 - JP 2014500723-A/175456: Polycomb-Associated Non-Coding RNAs.
LF367954 - JP 2014500723-A/175457: Polycomb-Associated Non-Coding RNAs.
LF367955 - JP 2014500723-A/175458: Polycomb-Associated Non-Coding RNAs.
LF367956 - JP 2014500723-A/175459: Polycomb-Associated Non-Coding RNAs.
LF367957 - JP 2014500723-A/175460: Polycomb-Associated Non-Coding RNAs.
LF367959 - JP 2014500723-A/175462: Polycomb-Associated Non-Coding RNAs.
LF367960 - JP 2014500723-A/175463: Polycomb-Associated Non-Coding RNAs.
LF367961 - JP 2014500723-A/175464: Polycomb-Associated Non-Coding RNAs.
LF367963 - JP 2014500723-A/175466: Polycomb-Associated Non-Coding RNAs.
LF367964 - JP 2014500723-A/175467: Polycomb-Associated Non-Coding RNAs.
LF367965 - JP 2014500723-A/175468: Polycomb-Associated Non-Coding RNAs.
LF367966 - JP 2014500723-A/175469: Polycomb-Associated Non-Coding RNAs.
LF367967 - JP 2014500723-A/175470: Polycomb-Associated Non-Coding RNAs.
LF367968 - JP 2014500723-A/175471: Polycomb-Associated Non-Coding RNAs.
MA603509 - JP 2018138019-A/175435: Polycomb-Associated Non-Coding RNAs.
MA603517 - JP 2018138019-A/175443: Polycomb-Associated Non-Coding RNAs.
MA603518 - JP 2018138019-A/175444: Polycomb-Associated Non-Coding RNAs.
MA603519 - JP 2018138019-A/175445: Polycomb-Associated Non-Coding RNAs.
MA603520 - JP 2018138019-A/175446: Polycomb-Associated Non-Coding RNAs.
MA603522 - JP 2018138019-A/175448: Polycomb-Associated Non-Coding RNAs.
MA603523 - JP 2018138019-A/175449: Polycomb-Associated Non-Coding RNAs.
MA603524 - JP 2018138019-A/175450: Polycomb-Associated Non-Coding RNAs.
MA603525 - JP 2018138019-A/175451: Polycomb-Associated Non-Coding RNAs.
MA603526 - JP 2018138019-A/175452: Polycomb-Associated Non-Coding RNAs.
MA603527 - JP 2018138019-A/175453: Polycomb-Associated Non-Coding RNAs.
MA603528 - JP 2018138019-A/175454: Polycomb-Associated Non-Coding RNAs.
MA603529 - JP 2018138019-A/175455: Polycomb-Associated Non-Coding RNAs.
MA603530 - JP 2018138019-A/175456: Polycomb-Associated Non-Coding RNAs.
MA603531 - JP 2018138019-A/175457: Polycomb-Associated Non-Coding RNAs.
MA603532 - JP 2018138019-A/175458: Polycomb-Associated Non-Coding RNAs.
MA603533 - JP 2018138019-A/175459: Polycomb-Associated Non-Coding RNAs.
MA603534 - JP 2018138019-A/175460: Polycomb-Associated Non-Coding RNAs.
MA603536 - JP 2018138019-A/175462: Polycomb-Associated Non-Coding RNAs.
MA603537 - JP 2018138019-A/175463: Polycomb-Associated Non-Coding RNAs.
MA603538 - JP 2018138019-A/175464: Polycomb-Associated Non-Coding RNAs.
MA603540 - JP 2018138019-A/175466: Polycomb-Associated Non-Coding RNAs.
MA603541 - JP 2018138019-A/175467: Polycomb-Associated Non-Coding RNAs.
MA603542 - JP 2018138019-A/175468: Polycomb-Associated Non-Coding RNAs.
MA603543 - JP 2018138019-A/175469: Polycomb-Associated Non-Coding RNAs.
MA603544 - JP 2018138019-A/175470: Polycomb-Associated Non-Coding RNAs.
MA603545 - JP 2018138019-A/175471: Polycomb-Associated Non-Coding RNAs.
AK027144 - Homo sapiens cDNA: FLJ23491 fis, clone LNG00825, highly similar to HSPM5 Human mRNA for pM5 protein.
LF367970 - JP 2014500723-A/175473: Polycomb-Associated Non-Coding RNAs.
JD144393 - Sequence 125417 from Patent EP1572962.
JD165404 - Sequence 146428 from Patent EP1572962.
JD107024 - Sequence 88048 from Patent EP1572962.
JD492568 - Sequence 473592 from Patent EP1572962.
JD231234 - Sequence 212258 from Patent EP1572962.
LF367971 - JP 2014500723-A/175474: Polycomb-Associated Non-Coding RNAs.
JD313854 - Sequence 294878 from Patent EP1572962.
JD485962 - Sequence 466986 from Patent EP1572962.
JD207815 - Sequence 188839 from Patent EP1572962.
LF367972 - JP 2014500723-A/175475: Polycomb-Associated Non-Coding RNAs.
MA603547 - JP 2018138019-A/175473: Polycomb-Associated Non-Coding RNAs.
MA603548 - JP 2018138019-A/175474: Polycomb-Associated Non-Coding RNAs.
MA603549 - JP 2018138019-A/175475: Polycomb-Associated Non-Coding RNAs.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000399336.1, ENST00000399336.2, ENST00000399336.3, ENST00000399336.4, ENST00000399336.5, ENST00000399336.6, ENST00000399336.7, ENST00000399336.8, NM_001004067, NOMO3_HUMAN, P69849, uc319agv.1, uc319agv.2
UCSC ID: ENST00000399336.9_9
RefSeq Accession: NM_001004067.4
Protein: P69849 (aka NOMO3_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.