ID:NOMO1_HUMAN DESCRIPTION: RecName: Full=Nodal modulator 1; AltName: Full=pM5 protein; Flags: Precursor; FUNCTION: May antagonize Nodal signaling (By similarity). SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein (Probable). TISSUE SPECIFICITY: Expressed in colon tumor tissue and in adjacent normal colonic mucosa. DEVELOPMENTAL STAGE: No difference between normal colonic mucosa and colon tumor tissue in mRNA expression, whereas the protein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue. CAUTION: There are 3 copies of the NOMO gene on chromosome 16p12- p13: NOMO1, NOMO2 (AC Q5JPE7) and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. Moreover, it does not allow a clear view of which variant belongs to which of the 3 copies. The results reported in other entries may therefore apply for this protein.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09430 - Protein of unknown function (DUF2012) PF13620 - Carboxypeptidase regulatory-like domain PF17802 - Prealbumin-like fold domain
SCOP Domains: 49265 - Fibronectin type III 49452 - Starch-binding domain-like 49464 - Carboxypeptidase regulatory domain-like 49478 - Cna protein B-type domain 49482 - Aromatic compound dioxygenase 117074 - Hypothetical protein PA1324
ModBase Predicted Comparative 3D Structure on Q15155
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
