Human Gene NME2 (ENST00000512737.6_4) from GENCODE V47lift37

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Description: NME/NM23 nucleoside diphosphate kinase 2, transcript variant 1 (from RefSeq NM_002512.4)
Gencode Transcript: ENST00000512737.6_4
Gencode Gene: ENSG00000243678.12_7
Transcript (Including UTRs)
Position: hg19 chr17:49,243,772-49,249,105 Size: 5,334 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr17:49,244,192-49,248,965 Size: 4,774 Coding Exon Count: 4

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:49,243,772-49,249,105)			mRNA (may differ from genome)		Protein (152 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	UniProtKB
Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: Q6FHN3_HUMAN DESCRIPTION: RecName: Full=Nucleoside diphosphate kinase; EC=2.7.4.6; CATALYTIC ACTIVITY: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate. SIMILARITY: Belongs to the NDK family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: NME2 Diseases sorted by gene-association score: myxosarcoma (1), lung sarcoma (1)

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D004052 Diethylnitrosamine D013749 Tetrachlorodibenzodioxin C029790 2,2',3',4,4',5-hexachlorobiphenyl C009505 4,4'-diaminodiphenylmethane C027576 4-hydroxy-2-nonenal D000082 Acetaminophen D000638 Amiodarone D000643 Ammonium Chloride D001374 Azacitidine D001553 Benzbromarone more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 7.45 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 205.87 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-34.10	91	-0.375	Picture	PostScript	Text
3' UTR	-34.50	140	-0.246	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001564 - Nucleoside_diP_kinase
IPR023005 - Nucleoside_diP_kinase_AS

Pfam Domains:
PF00334 - Nucleoside diphosphate kinase

SCOP Domains:
46785 - "Winged helix" DNA-binding domain
54919 - Nucleoside diphosphate kinase, NDK

ModBase Predicted Comparative 3D Structure on Q6FHN3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000166 nucleotide binding GO:0004550 nucleoside diphosphate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity Biological Process: GO:0006165 nucleoside diphosphate phosphorylation GO:0006183 GTP biosynthetic process GO:0006228 UTP biosynthetic process GO:0006241 CTP biosynthetic process GO:0016310 phosphorylation

Descriptions from all associated GenBank mRNAs


	AK313448 - Homo sapiens cDNA, FLJ93990, Homo sapiens non-metastatic cells 2, protein (NM23B) expressed in(NME2), mRNA. DQ109675 - Homo sapiens NM23-LV mRNA, complete cds. BC133029 - Homo sapiens NME1-NME2 readthrough transcript, mRNA (cDNA clone MGC:164660 IMAGE:40147051), complete cds. BC133031 - Homo sapiens NME1-NME2 readthrough transcript, mRNA (cDNA clone MGC:164662 IMAGE:40147053), complete cds. BC107894 - Homo sapiens NME1-NME2 readthrough transcript, mRNA (cDNA clone MGC:111212 IMAGE:6717551), complete cds. KJ901269 - Synthetic construct Homo sapiens clone ccsbBroadEn_10663 NME1-NME2 gene, encodes complete protein. D28391 - Homo sapiens mRNA for nucleotide diphosphate kinase B, 5'UTR region. M36981 - Human putative NDP kinase (nm23-H2S) mRNA, complete cds. X58965 - H.sapiens RNA for nm23-H2 gene. JD415566 - Sequence 396590 from Patent EP1572962. BC095458 - Homo sapiens non-metastatic cells 2, protein (NM23B) expressed in, mRNA (cDNA clone MGC:111348 IMAGE:30524221), complete cds. JD404673 - Sequence 385697 from Patent EP1572962. EU794639 - Homo sapiens epididymis secretory sperm binding protein Li 155an (HEL-S-155an) mRNA, complete cds. L16785 - Homo sapiens c-myc transcription factor (puf) mRNA, complete cds. BC002476 - Homo sapiens non-metastatic cells 2, protein (NM23B) expressed in, mRNA (cDNA clone MGC:2212 IMAGE:3349768), complete cds. BT007045 - Homo sapiens non-metastatic cells 2, protein (NM23B) expressed in mRNA, complete cds. CR541718 - Homo sapiens full open reading frame cDNA clone RZPDo834B0629D for gene NME2, non-metastatic cells 2, protein (NM23B) expressed in; complete cds, incl. stopcodon. JD023160 - Sequence 4184 from Patent EP1572962. JD033589 - Sequence 14613 from Patent EP1572962. FJ655905 - Homo sapiens RPL27-NME2 fusion mRNA, partial sequence. DL490559 - Novel nucleic acids. JD027157 - Sequence 8181 from Patent EP1572962. JD024122 - Sequence 5146 from Patent EP1572962. JD030914 - Sequence 11938 from Patent EP1572962. JD148163 - Sequence 129187 from Patent EP1572962. JD524167 - Sequence 505191 from Patent EP1572962. JD547287 - Sequence 528311 from Patent EP1572962. JD050537 - Sequence 31561 from Patent EP1572962.

Biochemical and Signaling Pathways


	BioCyc Knowledge Library PWY-7176 - UTP and CTP de novo biosynthesis PWY-7184 - pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7197 - pyrimidine deoxyribonucleotide phosphorylation PWY-7200 - superpathway of pyrimidine deoxyribonucleoside salvage PWY-7205 - CMP phosphorylation PWY-7210 - pyrimidine deoxyribonucleotides biosynthesis from CTP PWY-7211 - superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis PWY-7221 - guanosine ribonucleotides de novo biosynthesis PWY-7224 - purine deoxyribonucleosides salvage PWY-7226 - guanosine deoxyribonucleotides de novo biosynthesis PWY-7227 - adenosine deoxyribonucleotides de novo biosynthesis PWY-7228 - guanosine nucleotides de novo biosynthesis PWY-841 - purine nucleotides de novo biosynthesis PWY0-162 - superpathway of pyrimidine ribonucleotides de novo biosynthesis PWY66-409 - superpathway of purine nucleotide salvage BioCarta from NCI Cancer Genome Anatomy Project h_ndkDynaminPathway - Endocytotic role of NDK, Phosphins and Dynamin

Other Names for This Gene


	Alternate Gene Symbols: ENST00000512737.1, ENST00000512737.2, ENST00000512737.3, ENST00000512737.4, ENST00000512737.5, hCG_2001850 , HEL-S-155an , NME2 , NM_002512, Q6FHN3, Q6FHN3_HUMAN, uc323jhj.1, uc323jhj.2 UCSC ID: ENST00000512737.6_4 RefSeq Accession: NM_002512.4 Protein: Q6FHN3

Gene Model Information


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Methods, Credits, and Use Restrictions


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