ID:NALP5_HUMAN DESCRIPTION: RecName: Full=NACHT, LRR and PYD domains-containing protein 5; AltName: Full=Mater protein homolog; FUNCTION: As a member of the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions (By similarity). SUBUNIT: Component of the SCMC which also includes at least OOEP and TLE6 (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). Nucleus, nucleolus (By similarity). Cytoplasm (By similarity). Note=In the subcortical cytoplasm of early embryos from the 1-cell to the blastocyst stages. From the 2-cell stage, still detected in the subcortex, but excluded from cell-cell contact regions (By similarity). TISSUE SPECIFICITY: Oocyte-specific. SIMILARITY: Belongs to the NLRP family. SIMILARITY: Contains 1 DAPIN domain. SIMILARITY: Contains 13 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 NACHT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47986 - DEATH domain 52047 - RNI-like 52058 - L domain-like 52075 - Outer arm dynein light chain 1 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like
ModBase Predicted Comparative 3D Structure on P59047
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
