Human Gene NGDN (ENST00000408901.8_10) from GENCODE V47lift37

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Description: neuroguidin, transcript variant 1 (from RefSeq NM_001042635.2)
Gencode Transcript: ENST00000408901.8_10
Gencode Gene: ENSG00000129460.17_16
Transcript (Including UTRs)
Position: hg19 chr14:23,938,912-23,947,382 Size: 8,471 Total Exon Count: 11 Strand: +
Coding Region
Position: hg19 chr14:23,938,925-23,947,235 Size: 8,311 Coding Exon Count: 11

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:23,938,912-23,947,382)			mRNA (may differ from genome)		Protein (315 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: NGDN_HUMAN DESCRIPTION: RecName: Full=Neuroguidin; AltName: Full=EIF4E-binding protein; FUNCTION: Involved in the translational repression of cytoplasmic polyadenylation element (CPE)-containing mRNAs (By similarity). SUBUNIT: Interacts with CPEB1 and EIF4E (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). Cell projection, axon (By similarity). Cell projection, dendrite (By similarity). Cell projection, filopodium (By similarity). Note=Detected in axons, dendrites and filopodia. Colocalized with EIF4E in neurites (By similarity). SIMILARITY: Belongs to the SAS10 family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D001280 Atrazine D002251 Carbon Tetrachloride D019327 Copper Sulfate D003993 Dibutyl Phthalate D005557 Formaldehyde D010795 Phthalic Acids C016030 pantogab C017947 sodium arsenite

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 13.13 RPKM in Uterus Total median expression: 443.85 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-22.00	147	-0.150	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR007146 - Sas10/Utp3/C1D

Pfam Domains:
PF04000 - Sas10/Utp3/C1D family

ModBase Predicted Comparative 3D Structure on Q8NEJ9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) GO:0006417 regulation of translation Cellular Component: GO:0000775 chromosome, centromeric region GO:0005634 nucleus GO:0005694 chromosome GO:0005730 nucleolus GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0030175 filopodium GO:0030424 axon GO:0030425 dendrite GO:0032040 small-subunit processome GO:0042995 cell projection

Descriptions from all associated GenBank mRNAs


	HQ447612 - Synthetic construct Homo sapiens clone IMAGE:100070958; CCSB013125_01 neuroguidin, EIF4E binding protein (NGDN) gene, encodes complete protein. KJ898579 - Synthetic construct Homo sapiens clone ccsbBroadEn_07973 NGDN gene, encodes complete protein. AK124318 - Homo sapiens cDNA FLJ42327 fis, clone TRACH3000515. AK291875 - Homo sapiens cDNA FLJ75745 complete cds. BC030817 - Homo sapiens neuroguidin, EIF4E binding protein, mRNA (cDNA clone MGC:22786 IMAGE:4768089), complete cds. AL050003 - Homo sapiens mRNA; cDNA DKFZp564O092 (from clone DKFZp564O092). AK022215 - Homo sapiens cDNA FLJ12153 fis, clone MAMMA1000458. CU689028 - Synthetic construct Homo sapiens gateway clone IMAGE:100022195 5' read NGDN mRNA. EU832603 - Synthetic construct Homo sapiens clone HAIB:100067632; DKFZo004H0730 neuroguidin, EIF4E binding protein protein (NGDN) gene, encodes complete protein. EU832521 - Synthetic construct Homo sapiens clone HAIB:100067550; DKFZo008H0729 neuroguidin, EIF4E binding protein protein (NGDN) gene, encodes complete protein. JD249173 - Sequence 230197 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: A8K760, C14orf120, ENST00000408901.1, ENST00000408901.2, ENST00000408901.3, ENST00000408901.4, ENST00000408901.5, ENST00000408901.6, ENST00000408901.7, NGDN , NGDN_HUMAN, NM_001042635, Q8NEJ9, Q9Y400, uc319fbr.1, uc319fbr.2 UCSC ID: ENST00000408901.8_10 RefSeq Accession: NM_001042635.2 Protein: Q8NEJ9 (aka NGDN_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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