The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47454 - A DNA-binding domain in eukaryotic transcription factors 141371 - PilZ domain-like 57959 - Leucine zipper domain
ModBase Predicted Comparative 3D Structure on Q14494
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000976 transcription regulatory region sequence-specific DNA binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0003712 transcription cofactor activity GO:0005515 protein binding GO:0008289 lipid binding GO:0015485 cholesterol binding GO:0019904 protein domain specific binding GO:0044877 macromolecular complex binding GO:0046982 protein heterodimerization activity
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0006366 transcription from RNA polymerase II promoter GO:0006629 lipid metabolic process GO:0006783 heme biosynthetic process GO:0006954 inflammatory response GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0009653 anatomical structure morphogenesis GO:0030218 erythrocyte differentiation GO:0034599 cellular response to oxidative stress GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress GO:0042632 cholesterol homeostasis GO:0045454 cell redox homeostasis GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0055088 lipid homeostasis GO:0071397 cellular response to cholesterol GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress GO:1901329 regulation of odontoblast differentiation
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
