ID:NETO1_HUMAN DESCRIPTION: RecName: Full=Neuropilin and tolloid-like protein 1; AltName: Full=Brain-specific transmembrane protein containing 2 CUB and 1 LDL-receptor class A domains protein 1; Flags: Precursor; FUNCTION: Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D- aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity). SUBUNIT: Interacts with PLZ domains of DLG2, DLG3 and DLG4 via its C-terminal TRV domain. Interacts with GRIN2A and GRIN2B via its CUB domains (By similarity). SUBCELLULAR LOCATION: Isoform 2: Cell membrane; Single-pass type I membrane protein (Potential). Cell junction, synapse, postsynaptic cell membrane, postsynaptic density (By similarity). Note=Component of the postsynaptic density (PSD) of excitatory synapses (By similarity). SUBCELLULAR LOCATION: Isoform 3: Cell membrane; Single-pass type I membrane protein (Potential). SUBCELLULAR LOCATION: Isoform 1: Secreted (Potential). TISSUE SPECIFICITY: Isoform 1 and isoform 2 are retina-specific. Isoform 3 is found in retina as well as at lower levels in adult and fetal brain. SIMILARITY: Contains 2 CUB domains. SIMILARITY: Contains 1 LDL-receptor class A domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDF5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
