ID:ACPM_HUMAN DESCRIPTION: RecName: Full=Acyl carrier protein, mitochondrial; Short=ACP; AltName: Full=CI-SDAP; AltName: Full=NADH-ubiquinone oxidoreductase 9.6 kDa subunit; Flags: Precursor; FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis in mitochondria. Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain (By similarity). SUBUNIT: Mammalian complex I is composed of 45 different subunits. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Contains 1 acyl carrier domain. SEQUENCE CAUTION: Sequence=AAC05814.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O14561
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000035 acyl binding GO:0000036 ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process GO:0005504 fatty acid binding GO:0005509 calcium ion binding GO:0005515 protein binding GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0031177 phosphopantetheine binding
Biological Process: GO:0006120 mitochondrial electron transport, NADH to ubiquinone GO:0006629 lipid metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0009245 lipid A biosynthetic process GO:0009249 protein lipoylation GO:0032981 mitochondrial respiratory chain complex I assembly GO:0055114 oxidation-reduction process
BioCyc Knowledge Library PWY-3781 - aerobic respiration I (cytochrome c) PWY0-501 - lipoate biosynthesis and incorporation PWY66-429 - fatty acid biosynthesis initiation (mitochondria) PWY66-430 - myristate biosynthesis (mitochondria)
Reactome (by CSHL, EBI, and GO)
Protein O14561 (Reactome details) participates in the following event(s):
R-HSA-6793590 LIPT2 transfers octanoyl group to GCSH R-HSA-8933547 MCAT transfers Mal from Mal-CoA to NDUFAB1 R-HSA-6799178 Intermediate 1 binds HP subcomplex to form Intermediate 2 R-HSA-6799191 Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex R-HSA-6799202 The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex R-HSA-6799197 ND4, ND5 bind the 550kDa complex to form the 815kDa complex R-HSA-6799179 Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex R-HSA-6799196 The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I R-HSA-163217 Complex I oxidises NADH to NAD+, reduces CoQ to QH2 R-HSA-389661 Glyoxylate metabolism and glycine degradation R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation R-HSA-6799198 Complex I biogenesis R-HSA-71291 Metabolism of nitrogenous molecules R-HSA-8978868 Fatty acid metabolism R-HSA-611105 Respiratory electron transport R-HSA-1430728 Metabolism R-HSA-556833 Metabolism of lipids R-HSA-163200 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
