ID:SPN90_HUMAN DESCRIPTION: RecName: Full=NCK-interacting protein with SH3 domain; AltName: Full=54 kDa VacA-interacting protein; AltName: Full=54 kDa vimentin-interacting protein; Short=VIP54; AltName: Full=90 kDa SH3 protein interacting with Nck; AltName: Full=AF3p21; AltName: Full=Dia-interacting protein 1; Short=DIP-1; AltName: Full=Diaphanous protein-interacting protein; AltName: Full=SH3 adapter protein SPIN90; AltName: Full=WASP-interacting SH3-domain protein; Short=WISH; AltName: Full=Wiskott-Aldrich syndrome protein-interacting protein; FUNCTION: Has an important role in stress fiber formation induced by active diaphanous protein homolog 1 (DRF1). Induces microspike formation, in vivo (By similarity). In vitro, stimulates N-WASP- induced ARP2/3 complex activation in the absence of CDC42 (By similarity). May play an important role in the maintenance of sarcomeres and/or in the assembly of myofibrils into sarcomeres. Implicated in regulation of actin polymerization and cell adhesion. Plays a role in angiogenesis. SUBUNIT: Associates with the intermediate filaments, vimentin and desmin. Binds the first and third SH3 domains of NCK. Binds the proline-rich domains of N-WASP through its SH3 domain (By similarity). Similarly, binds diaphanous protein homolog 1 (DRF1). Binds the SH3 domains of GRB2 through its proline-rich domains. Interacts with Helicobacter pylori toxin vacA. Isoform 4 interacts with FHOD1. Interacts with FASLG. Interacts with TMIGD2. SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with DRF1 at membrane ruffles, and with Nck at Z-disks in mature cardiac myocytes. TISSUE SPECIFICITY: Highest expression in heart, brain, skeletal muscle, kidney and liver. Lower levels in placenta, lung, small intestine and leukocytes. Weak expression in colon, thymus and spleen. DISEASE: Note=A chromosomal aberration involving NCKIPSD/AF3p21 is found in therapy-related leukemia. Translocation t(3;11)(p21;q23) with MLL. SIMILARITY: Contains 1 SH3 domain. SEQUENCE CAUTION: Sequence=BAG57476.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/AF3p21ID228.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00018 - SH3 domain PF07653 - Variant SH3 domain PF09431 - Protein of unknown function (DUF2013)
SCOP Domains: 48371 - ARM repeat 50044 - SH3-domain
ModBase Predicted Comparative 3D Structure on Q9NZQ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006607 NLS-bearing protein import into nucleus GO:0007010 cytoskeleton organization GO:0007165 signal transduction GO:0010976 positive regulation of neuron projection development GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
