Human Gene NAA25 (ENST00000261745.9_7) from GENCODE V47lift37
  Description: N-alpha-acetyltransferase 25, NatB auxiliary subunit (from RefSeq NM_024953.4)
Gencode Transcript: ENST00000261745.9_7
Gencode Gene: ENSG00000111300.10_10
Transcript (Including UTRs)
   Position: hg19 chr12:112,464,493-112,546,587 Size: 82,095 Total Exon Count: 24 Strand: -
Coding Region
   Position: hg19 chr12:112,467,335-112,546,577 Size: 79,243 Coding Exon Count: 24 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr12:112,464,493-112,546,587)mRNA (may differ from genome)Protein (972 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMalacardsMGIOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: NAA25_HUMAN
DESCRIPTION: RecName: Full=N-alpha-acetyltransferase 25, NatB auxiliary subunit; AltName: Full=Mitochondrial distribution and morphology protein 20; AltName: Full=N-terminal acetyltransferase B complex subunit MDM20; Short=NatB complex subunit MDM20; AltName: Full=N-terminal acetyltransferase B complex subunit NAA25; AltName: Full=p120;
FUNCTION: Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.
SUBUNIT: Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.
INTERACTION: P24941:CDK2; NbExp=1; IntAct=EBI-1048503, EBI-375096;
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the MDM20/NAA25 family.
SIMILARITY: Contains 4 TPR repeats.
SEQUENCE CAUTION: Sequence=BAB14432.1; Type=Erroneous initiation; Sequence=CAE46062.1; Type=Erroneous initiation;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NAA25
Diseases sorted by gene-association score: ogden syndrome (2), rheumatoid arthritis, systemic juvenile (1)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 10.26 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 267.89 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
3' UTR -704.202842-0.248 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR019183 - N-acetylTrfase_B_cplx_non-cat
IPR013026 - TPR-contain_dom
IPR011990 - TPR-like_helical

Pfam Domains:
PF09797 - N-acetyltransferase B complex (NatB) non catalytic subunit

SCOP Domains:
81901 - HCP-like
48439 - Protein prenylyltransferase
48452 - TPR-like
144059 - ImpE-like

ModBase Predicted Comparative 3D Structure on Q14CX7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologGenome BrowserGenome Browser
Gene DetailsGene Details Gene DetailsGene DetailsGene Details
Gene SorterGene Sorter Gene SorterGene SorterGene Sorter
 RGDEnsembl WormBaseSGD
    Protein SequenceProtein Sequence
    AlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004596 peptide alpha-N-acetyltransferase activity

Biological Process:
GO:0017196 N-terminal peptidyl-methionine acetylation

Cellular Component:
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0031416 NatB complex


-  Descriptions from all associated GenBank mRNAs
  BC047640 - Homo sapiens chromosome 12 open reading frame 30, mRNA (cDNA clone IMAGE:4823837).
BX647450 - Homo sapiens mRNA; cDNA DKFZp451H017 (from clone DKFZp451H017).
AL832394 - Homo sapiens mRNA; cDNA DKFZp667K2112 (from clone DKFZp667K2112).
BX641140 - Homo sapiens mRNA; cDNA DKFZp686H03169 (from clone DKFZp686H03169).
AK023151 - Homo sapiens cDNA FLJ13089 fis, clone NT2RP3002108, weakly similar to DEC1 PROTEIN.
BC113587 - Homo sapiens chromosome 12 open reading frame 30, mRNA (cDNA clone MGC:142147 IMAGE:8322639), complete cds.
BC113585 - Homo sapiens chromosome 12 open reading frame 30, mRNA (cDNA clone MGC:142145 IMAGE:8322637), complete cds.
AK292485 - Homo sapiens cDNA FLJ75187 complete cds, highly similar to Homo sapiens nap1 mRNA for P120.
JD419228 - Sequence 400252 from Patent EP1572962.
AB054990 - Homo sapiens nap1 mRNA for P120, complete cds.
AK309772 - Homo sapiens cDNA, FLJ99813.
BX647992 - Homo sapiens mRNA; cDNA DKFZp686P0152 (from clone DKFZp686P0152).
BC065481 - Homo sapiens chromosome 12 open reading frame 30, mRNA (cDNA clone IMAGE:5932893).
BC095484 - Homo sapiens cDNA clone IMAGE:30344867, containing frame-shift errors.
BC034357 - Homo sapiens chromosome 12 open reading frame 30, mRNA (cDNA clone IMAGE:3867555), partial cds.
AK307494 - Homo sapiens cDNA, FLJ97442.
JD163140 - Sequence 144164 from Patent EP1572962.
JD494992 - Sequence 476016 from Patent EP1572962.
JD474932 - Sequence 455956 from Patent EP1572962.
JD451091 - Sequence 432115 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  BioCyc Knowledge Library
PWY-7799 - Arg/N-end rule pathway (eukaryotic)

-  Other Names for This Gene
  Alternate Gene Symbols: A0JLU7, C12orf30, ENST00000261745.1, ENST00000261745.2, ENST00000261745.3, ENST00000261745.4, ENST00000261745.5, ENST00000261745.6, ENST00000261745.7, ENST00000261745.8, MDM20, NAA25_HUMAN, NAP1, NM_024953, Q14CX7, Q6MZH1, Q7Z4N6, Q9H911, uc317gtg.1, uc317gtg.2
UCSC ID: ENST00000261745.9_7
RefSeq Accession: NM_024953.4
Protein: Q14CX7 (aka NAA25_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.