Human Gene MZT2A (ENST00000309451.7_7) from GENCODE V47lift37
  Description: mitotic spindle organizing protein 2A (from RefSeq NM_001085365.2)
Gencode Transcript: ENST00000309451.7_7
Gencode Gene: ENSG00000173272.16_10
Transcript (Including UTRs)
   Position: hg19 chr2:132,241,533-132,249,970 Size: 8,438 Total Exon Count: 3 Strand: -
Coding Region
   Position: hg19 chr2:132,241,634-132,249,949 Size: 8,316 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:132,241,533-132,249,970)mRNA (may differ from genome)Protein (158 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MZT2A_HUMAN
DESCRIPTION: RecName: Full=Mitotic-spindle organizing protein 2A; AltName: Full=Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A;
SUBUNIT: Part of the gamma-tubulin complex.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, centrosome. Cytoplasm, cytoskeleton, spindle.
SIMILARITY: Belongs to the MOZART2 family.
SEQUENCE CAUTION: Sequence=AAX93252.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.24 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1099.41 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -3.2021-0.152 Picture PostScript Text
3' UTR -24.20101-0.240 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR024332 - MOZART2

Pfam Domains:
PF12926 - Mitotic-spindle organizing gamma-tubulin ring associated

ModBase Predicted Comparative 3D Structure on Q6P582
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0008274 gamma-tubulin ring complex


-  Descriptions from all associated GenBank mRNAs
  BC063024 - Homo sapiens family with sequence similarity 128, member A, mRNA (cDNA clone IMAGE:6094029), partial cds.
BC018206 - Homo sapiens family with sequence similarity 128, member A, mRNA (cDNA clone MGC:8772 IMAGE:3862861), complete cds.
BC104650 - Homo sapiens family with sequence similarity 128, member A, mRNA (cDNA clone IMAGE:6733400), partial cds.
KJ906499 - Synthetic construct Homo sapiens clone ccsbBroadEn_16169 MZT2A gene, encodes complete protein.
AK090531 - Homo sapiens cDNA FLJ33212 fis, clone ADRGL2009533.
AX746496 - Sequence 21 from Patent EP1308459.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q6P582 (Reactome details) participates in the following event(s):

R-HSA-380283 Recruitment of additional gamma tubulin/ gamma TuRC to the centrosome
R-HSA-380508 Translocation of NuMA to the centrosomes
R-HSA-380316 Association of NuMA with microtubules
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-380287 Centrosome maturation
R-HSA-68877 Mitotic Prometaphase
R-HSA-69275 G2/M Transition
R-HSA-68886 M Phase
R-HSA-453274 Mitotic G2-G2/M phases
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-1640170 Cell Cycle

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000309451.1, ENST00000309451.2, ENST00000309451.3, ENST00000309451.4, ENST00000309451.5, ENST00000309451.6, FAM128A, MOZART2A, MZT2A_HUMAN, NM_001085365, Q3SWV8, Q6P582, Q8WVB2, uc317onp.1, uc317onp.2
UCSC ID: ENST00000309451.7_7
RefSeq Accession: NM_001085365.2
Protein: Q6P582 (aka MZT2A_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.