Human Gene MYOM2 (ENST00000262113.9_5) from GENCODE V47lift37
Description: myomesin 2 (from RefSeq NM_003970.4)Gencode Transcript: ENST00000262113.9_5Gencode Gene: ENSG00000036448.10_8Transcript (Including UTRs) Position: hg19 chr8:1,993,161-2,093,380 Size: 100,220 Total Exon Count: 38 Strand: +Coding Region Position: hg19 chr8:1,998,881-2,092,905 Size: 94,025 Coding Exon Count: 37
Data last updated at UCSC: 2024-08-22 23:36:26
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MYOM2_HUMAN DESCRIPTION: RecName: Full=Myomesin-2; AltName: Full=165 kDa connectin-associated protein; AltName: Full=165 kDa titin-associated protein; AltName: Full=M-protein; AltName: Full=Myomesin family member 2;FUNCTION: Major component of the vertebrate myofibrillar M band. Binds myosin, titin, and light meromyosin. This binding is dose dependent.SUBUNIT: Interacts with TTN/titin (By similarity).INTERACTION: P35609:ACTN2; NbExp=2; IntAct=EBI-5357134, EBI-77797; O75923:DYSF; NbExp=3; IntAct=EBI-5357134, EBI-2799016; P21817:RYR1; NbExp=2; IntAct=EBI-5357134, EBI-1221290; Q8WZ42:TTN; NbExp=2; IntAct=EBI-5357134, EBI-681210;SIMILARITY: Contains 5 fibronectin type-III domains.SIMILARITY: Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
Primer design for this transcript
MalaCards Disease Associations
MalaCards Gene Search: MYOM2
Diseases sorted by gene-association score: rheumatic fever (35), plasma cell neoplasm (19), rheumatic heart disease (18), osteosclerotic myeloma (17), smoldering myeloma (17), non-secretory myeloma (16), solitary osseous plasmacytoma (16), glomeruloid hemangioma (16), indolent myeloma (15), toxic shock syndrome (14), poems syndrome (13), mature b-cell neoplasm (13), neurogenic arthropathy (10), scarlet fever (10), monoclonal gammopathy of uncertain significance (9), hypersensitivity reaction type iv disease (9), plasma protein metabolism disease (9), median neuropathy (8), streptococcal toxic-shock syndrome (7), mononeuritis of upper limb and mononeuritis multiplex (7), ecthyma (7), pharyngitis (6), commensal bacterial infectious disease (6), polyclonal hypergammaglobulinemia (6), papilledema (6), panencephalitis, subacute sclerosing (6), impetigo (6), glycogen storage disease vii (6), amyloid tumor (6), 3-methylglutaconic aciduria, type iv (6), sciatic neuropathy (6), necrotizing fasciitis (5), murray valley encephalitis (5), mononeuropathy (5), chronic polyneuropathy (5), retinitis pigmentosa 30 (5), streptococcal meningitis (5), peripheral nervous system disease (4), upper respiratory tract disease (4), multiple myeloma (3)
Comparative Toxicogenomics Database (CTD)
Common Gene Haplotype Alleles
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR003961 - Fibronectin_type3IPR007110 - Ig-likeIPR013783 - Ig-like_foldIPR013098 - Ig_I-setIPR003599 - Ig_subIPR003598 - Ig_sub2Pfam Domains: PF00041 - Fibronectin type III domainPF00047 - Immunoglobulin domainPF07679 - Immunoglobulin I-set domainPF13895 - Immunoglobulin domainPF13927 - Immunoglobulin domainSCOP Domains: 48726 - Immunoglobulin49265 - Fibronectin type IIIModBase Predicted Comparative 3D Structure on P54296 The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AK297890 - Homo sapiens cDNA FLJ58401 complete cds, highly similar to Myomesin-2.BC052969 - Homo sapiens myomesin (M-protein) 2, 165kDa, mRNA (cDNA clone MGC:54260 IMAGE:6205359), complete cds.JD290328 - Sequence 271352 from Patent EP1572962.X69089 - Homo sapiens mRNA for skeletal muscle 165kD protein.JD361133 - Sequence 342157 from Patent EP1572962.AB384710 - Synthetic construct DNA, clone: pF1KB1755, Homo sapiens MYOM2 gene for myomesin-2, complete cds, without stop codon, in Flexi system.JD131738 - Sequence 112762 from Patent EP1572962.JD508420 - Sequence 489444 from Patent EP1572962.JD372619 - Sequence 353643 from Patent EP1572962.JD498574 - Sequence 479598 from Patent EP1572962.JD410991 - Sequence 392015 from Patent EP1572962.JD400463 - Sequence 381487 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: ENST00000262113.1, ENST00000262113.2, ENST00000262113.3, ENST00000262113.4, ENST00000262113.5, ENST00000262113.6, ENST00000262113.7, ENST00000262113.8, MYOM2_HUMAN, NM_003970, P54296, Q7Z3Y2, uc317gwx.1, uc317gwx.2UCSC ID: ENST00000262113.9_5RefSeq Accession: NM_003970.4 Protein: P54296
(aka MYOM2_HUMAN or MYM2_HUMAN)
Gene Model Information
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Methods, Credits, and Use Restrictions
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US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
