Human Gene MYO5C (ENST00000261839.12_7) from GENCODE V47lift37
  Description: myosin VC (from RefSeq NM_018728.4)
Gencode Transcript: ENST00000261839.12_7
Gencode Gene: ENSG00000128833.13_9
Transcript (Including UTRs)
   Position: hg19 chr15:52,484,519-52,588,001 Size: 103,483 Total Exon Count: 41 Strand: -
Coding Region
   Position: hg19 chr15:52,486,099-52,587,833 Size: 101,735 Coding Exon Count: 41 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr15:52,484,519-52,588,001)mRNA (may differ from genome)Protein (1742 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYO5C_HUMAN
DESCRIPTION: RecName: Full=Unconventional myosin-Vc;
FUNCTION: May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues.
TISSUE SPECIFICITY: Expressed chiefly in non-neuronal tissues. Particularly abundant in epithelial and glandular tissues including pancreas, prostate, mammary, stomach, colon and lung.
SIMILARITY: Contains 1 dilute domain.
SIMILARITY: Contains 6 IQ domains.
SIMILARITY: Contains 1 myosin head-like domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 13.88 RPKM in Thyroid
Total median expression: 195.28 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -77.40168-0.461 Picture PostScript Text
3' UTR -396.101580-0.251 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018444 - Dil_domain
IPR002710 - Dilute
IPR000048 - IQ_motif_EF-hand-BS
IPR001609 - Myosin_head_motor_dom

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF00612 - IQ calmodulin-binding motif
PF01843 - DIL domain

SCOP Domains:
46689 - Homeodomain-like
50084 - Myosin S1 fragment, N-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases
55681 - Class II aaRS and biotin synthetases
111474 - Coronavirus S2 glycoprotein

ModBase Predicted Comparative 3D Structure on Q9NQX4
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0051015 actin filament binding

Biological Process:
GO:0007018 microtubule-based movement

Cellular Component:
GO:0016459 myosin complex
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  AF272390 - Homo sapiens myosin 5c (MYO5C) mRNA, complete cds.
BC144611 - Homo sapiens cDNA clone IMAGE:9053142.
BC167830 - Synthetic construct Homo sapiens clone IMAGE:100068220, MGC:195837 myosin VC (MYO5C) mRNA, encodes complete protein.
AK304136 - Homo sapiens cDNA FLJ61542 complete cds, highly similar to Myosin-5C.
BC064841 - Homo sapiens myosin VC, mRNA (cDNA clone IMAGE:6182837), complete cds.
KJ902896 - Synthetic construct Homo sapiens clone ccsbBroadEn_12290 MYO5C gene, encodes complete protein.
AK301079 - Homo sapiens cDNA FLJ57610 complete cds, highly similar to Myosin-5C.
JD165122 - Sequence 146146 from Patent EP1572962.
JD236991 - Sequence 218015 from Patent EP1572962.
JD443571 - Sequence 424595 from Patent EP1572962.
JD085343 - Sequence 66367 from Patent EP1572962.
JD563033 - Sequence 544057 from Patent EP1572962.
JD296884 - Sequence 277908 from Patent EP1572962.
JD552482 - Sequence 533506 from Patent EP1572962.
JD426706 - Sequence 407730 from Patent EP1572962.
JD553898 - Sequence 534922 from Patent EP1572962.
JD499588 - Sequence 480612 from Patent EP1572962.
JD488991 - Sequence 470015 from Patent EP1572962.
JD499587 - Sequence 480611 from Patent EP1572962.
JD220885 - Sequence 201909 from Patent EP1572962.
JD321994 - Sequence 303018 from Patent EP1572962.
JD292262 - Sequence 273286 from Patent EP1572962.
JD070325 - Sequence 51349 from Patent EP1572962.
JD467895 - Sequence 448919 from Patent EP1572962.
JD213574 - Sequence 194598 from Patent EP1572962.
JD533844 - Sequence 514868 from Patent EP1572962.
JD407928 - Sequence 388952 from Patent EP1572962.
JD258889 - Sequence 239913 from Patent EP1572962.
JD353186 - Sequence 334210 from Patent EP1572962.
JD353185 - Sequence 334209 from Patent EP1572962.
JD273881 - Sequence 254905 from Patent EP1572962.
JD524140 - Sequence 505164 from Patent EP1572962.
JD417984 - Sequence 399008 from Patent EP1572962.
JD465135 - Sequence 446159 from Patent EP1572962.
JD140524 - Sequence 121548 from Patent EP1572962.
JD566856 - Sequence 547880 from Patent EP1572962.
JD266196 - Sequence 247220 from Patent EP1572962.
JD346936 - Sequence 327960 from Patent EP1572962.
JD037043 - Sequence 18067 from Patent EP1572962.
JD431344 - Sequence 412368 from Patent EP1572962.
JD117813 - Sequence 98837 from Patent EP1572962.
DQ578755 - Homo sapiens piRNA piR-46867, complete sequence.
AF161352 - Homo sapiens HSPC089 mRNA, partial cds.
AK131493 - Homo sapiens cDNA FLJ16687 fis, clone TRACH2024559.
L29144 - Homo sapiens myosin mRNA, partial cds.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000261839.1, ENST00000261839.10, ENST00000261839.11, ENST00000261839.2, ENST00000261839.3, ENST00000261839.4, ENST00000261839.5, ENST00000261839.6, ENST00000261839.7, ENST00000261839.8, ENST00000261839.9, MYO5C_HUMAN, NM_018728, Q6P1W8, Q9NQX4, uc317gug.1, uc317gug.2
UCSC ID: ENST00000261839.12_7
RefSeq Accession: NM_018728.4
Protein: Q9NQX4 (aka MYO5C_HUMAN or MY5C_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.