ID:MYO5B_HUMAN DESCRIPTION: RecName: Full=Unconventional myosin-Vb; FUNCTION: May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis (By similarity). SUBUNIT: Component of the CART complex, at least composed of ACTN4, HGS/HRS, MYO5B and TRIM3. Interacts with RAB11FIP2, RAB11A, and RAB8A. Found in a complex with CFTR and RAB11A. Interacts with NPC1L1. DISEASE: Defects in MYO5B are a cause of diarrhea type 2 (DIAR2) [MIM:251850]. DIAR2 is characterized by onset of intractable life- threatening watery diarrhea during infancy. Two forms are recognized: early-onset MVID with diarrhea beginning in the neonatal period, and late-onset, with first symptoms appearing after 3 or 4 months of life. SIMILARITY: Contains 1 dilute domain. SIMILARITY: Contains 6 IQ domains. SIMILARITY: Contains 1 myosin head-like domain. SEQUENCE CAUTION: Sequence=BAA86433.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9ULV0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AB032945 - Homo sapiens KIAA1119 mRNA for KIAA1119 protein. AB290160 - Homo sapiens mRNA for MYO5B/KIAA1119 variant protein, complete cds. AK093149 - Homo sapiens cDNA FLJ35830 fis, clone TESTI2006465, highly similar to Myosin-5B. AX747955 - Sequence 1480 from Patent EP1308459. AY274809 - Homo sapiens myosin 5B (MYO5B) mRNA, complete cds. AK301976 - Homo sapiens cDNA FLJ58435 complete cds, highly similar to Myosin-5B. AB384567 - Synthetic construct DNA, clone: pF1KA1119, Homo sapiens MYO5B gene for myosin-Vb, complete cds, without stop codon, in Flexi system. BC033527 - Homo sapiens myosin VB, mRNA (cDNA clone IMAGE:5162990), complete cds. AL133643 - Homo sapiens mRNA; cDNA DKFZp434F1314 (from clone DKFZp434F1314). AK025336 - Homo sapiens cDNA: FLJ21683 fis, clone COL09335. JD328013 - Sequence 309037 from Patent EP1572962. JD049390 - Sequence 30414 from Patent EP1572962. L29143 - Homo sapiens myosin mRNA, partial cds.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9ULV0 (Reactome details) participates in the following event(s):
R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-445717 Aquaporin-mediated transport R-HSA-382551 Transport of small molecules
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
