ID:MYO15_HUMAN DESCRIPTION: RecName: Full=Unconventional myosin-XV; AltName: Full=Unconventional myosin-15; FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity). SUBUNIT: Interacts with the third PDZ domain of WHRN which is necessary for localization of WHRN to stereocilium tips (By similarity). Interacts with FASLG. SUBCELLULAR LOCATION: Cell projection, stereocilium (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Localizes to stereocilium tips in cochlear and vestibular hair cells (By similarity). TISSUE SPECIFICITY: Highly expressed in pituitary. Also expressed at lower levels in adult brain, kidney, liver, lung, pancreas, placenta and skeletal muscle. Not expressed in brain. In the pituitary, highly expressed in anterior gland cells. DISEASE: Defects in MYO15A are the cause of deafness autosomal recessive type 3 (DFNB3) [MIM:600316]. DFNB3 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. SIMILARITY: Contains 1 FERM domain. SIMILARITY: Contains 3 IQ domains. SIMILARITY: Contains 1 myosin head-like domain. SIMILARITY: Contains 2 MyTH4 domains. SIMILARITY: Contains 1 SH3 domain. CAUTION: Represents a unconventional myosin. This protein should not be confused with the conventional myosin-15 (MYH15).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
SCOP Domains: 47031 - Second domain of FERM 50022 - ISP domain 50044 - SH3-domain 50729 - PH domain-like 52540 - P-loop containing nucleoside triphosphate hydrolases 53795 - PEP carboxykinase-like
ModBase Predicted Comparative 3D Structure on Q9UKN7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
