ID:MYH7B_HUMAN DESCRIPTION: RecName: Full=Myosin-7B; AltName: Full=Antigen MLAA-21; AltName: Full=Myosin cardiac muscle beta chain; AltName: Full=Myosin heavy chain 7B, cardiac muscle beta isoform; AltName: Full=Slow A MYH14; FUNCTION: Involved in muscle contraction. SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity). SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein. TISSUE SPECIFICITY: Expressed in heart, skeletal muscle, testis, and all specific brain regions examined. Slightly lower expression was detected in ovary and kidney, and intermediate expression was detected in lung, pancreas, spleen and liver. DEVELOPMENTAL STAGE: Found in fetal liver and brain. MISCELLANEOUS: Expression does not vary in normal patients compared to patients with acute monocytic leukemia. MISCELLANEOUS: The cardiac alpha isoform is a 'fast' ATPase myosin, while the beta isoform is a 'slow' ATPase. SIMILARITY: Contains 1 IQ domain. SIMILARITY: Contains 1 myosin head-like domain. CAUTION: This protein sequence has been named 'Slow A' MYH14 (PubMed:11919279), but it also appears also as 'Slow B' MYH15 within the reference. CAUTION: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-7 (MYO7). SEQUENCE CAUTION: Sequence=AAI51243.1; Type=Erroneous initiation; Sequence=BAA96036.2; Type=Erroneous initiation; Sequence=CAI19310.2; Type=Erroneous gene model prediction; Sequence=CAI43047.2; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on A7E2Y1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
