Human Gene MYH15 (ENST00000693548.1_4) from GENCODE V47lift37
  Description: myosin heavy chain 15 (from RefSeq NM_014981.3)
Gencode Transcript: ENST00000693548.1_4
Gencode Gene: ENSG00000144821.11_11
Transcript (Including UTRs)
   Position: hg19 chr3:108,099,215-108,229,443 Size: 130,229 Total Exon Count: 41 Strand: -
Coding Region
   Position: hg19 chr3:108,100,392-108,229,377 Size: 128,986 Coding Exon Count: 41 

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Gene AllelesMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:108,099,215-108,229,443)mRNA (may differ from genome)Protein (1926 aa)
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BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYH15_HUMAN
DESCRIPTION: RecName: Full=Myosin-15; AltName: Full=Myosin heavy chain 15;
FUNCTION: Muscle contraction (By similarity).
SUBUNIT: Muscle myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2) (By similarity).
SUBCELLULAR LOCATION: Cytoplasm, myofibril. Note=Thick filaments of the myofibrils.
DOMAIN: The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils (By similarity).
SIMILARITY: Contains 1 IQ domain.
SIMILARITY: Contains 1 myosin head-like domain.
CAUTION: Represents a conventional myosin. This protein should not be confused with the unconventional myosin-15 (MYO15).
SEQUENCE CAUTION: Sequence=BAA76844.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MYH15
Diseases sorted by gene-association score: autosomal recessive nonsyndromic deafness 3 (8)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
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+  Microarray Expression Data
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-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -9.0066-0.136 Picture PostScript Text
3' UTR -318.201177-0.270 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR015650 - Myosin_1/23/4/7/8/13/15
IPR001609 - Myosin_head_motor_dom
IPR004009 - Myosin_N
IPR002928 - Myosin_tail

Pfam Domains:
PF00063 - Myosin head (motor domain)
PF01576 - Myosin tail
PF02736 - Myosin N-terminal SH3-like domain

SCOP Domains:
141004 - RelB-like
47413 - lambda repressor-like DNA-binding domains
50084 - Myosin S1 fragment, N-terminal domain
52540 - P-loop containing nucleoside triphosphate hydrolases
53795 - PEP carboxykinase-like
111357 - Mitochondrial ATP synthase coupling factor 6
90257 - Myosin rod fragments
57997 - Tropomyosin

ModBase Predicted Comparative 3D Structure on Q9Y2K3
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000166 nucleotide binding
GO:0003774 motor activity
GO:0003777 microtubule motor activity
GO:0003779 actin binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0051015 actin filament binding

Biological Process:
GO:0002074 extraocular skeletal muscle development
GO:0007018 microtubule-based movement

Cellular Component:
GO:0005737 cytoplasm
GO:0016459 myosin complex
GO:0030016 myofibril
GO:0032982 myosin filament


-  Descriptions from all associated GenBank mRNAs
  AB023217 - Homo sapiens KIAA1000 mRNA for KIAA1000 protein.
AK055436 - Homo sapiens cDNA FLJ30874 fis, clone FEBRA2004329, moderately similar to MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ISOFORM.
BC172390 - Synthetic construct Homo sapiens clone IMAGE:100069084, MGC:199095 myosin, heavy chain 15 (MYH15) mRNA, encodes complete protein.
AB463133 - Synthetic construct DNA, clone: pF1KA1000, Homo sapiens MYH15 gene for myosin, heavy chain 15, without stop codon, in Flexi system.
AK126801 - Homo sapiens cDNA FLJ44851 fis, clone BRACE3051819, moderately similar to Myosin heavy chain, cardiac muscle alpha isoform.
JD040882 - Sequence 21906 from Patent EP1572962.
JD515131 - Sequence 496155 from Patent EP1572962.
JD328878 - Sequence 309902 from Patent EP1572962.
JD265843 - Sequence 246867 from Patent EP1572962.
JD300090 - Sequence 281114 from Patent EP1572962.
JD119609 - Sequence 100633 from Patent EP1572962.
JD162952 - Sequence 143976 from Patent EP1572962.
JD150486 - Sequence 131510 from Patent EP1572962.
JD134919 - Sequence 115943 from Patent EP1572962.
JD371525 - Sequence 352549 from Patent EP1572962.
JD484021 - Sequence 465045 from Patent EP1572962.
JD552704 - Sequence 533728 from Patent EP1572962.
JD371187 - Sequence 352211 from Patent EP1572962.
JD197422 - Sequence 178446 from Patent EP1572962.
JD250540 - Sequence 231564 from Patent EP1572962.
JD509076 - Sequence 490100 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: KIAA1000, MYH15_HUMAN, NM_014981, Q9Y2K3, uc330yrx.1, uc330yrx.2
UCSC ID: ENST00000693548.1_4
RefSeq Accession: NM_014981.3
Protein: Q9Y2K3 (aka MYH15_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.