Human Gene MYCBP (ENST00000397572.5_9) from GENCODE V47lift37
  Description: MYC binding protein, transcript variant 1 (from RefSeq NM_012333.5)
Gencode Transcript: ENST00000397572.5_9
Gencode Gene: ENSG00000214114.9_10
Transcript (Including UTRs)
   Position: hg19 chr1:39,328,165-39,339,020 Size: 10,856 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:39,330,342-39,338,977 Size: 8,636 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:39,328,165-39,339,020)mRNA (may differ from genome)Protein (103 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MYCBP_HUMAN
DESCRIPTION: RecName: Full=C-Myc-binding protein; AltName: Full=Associate of Myc 1; Short=AMY-1;
FUNCTION: May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
SUBUNIT: Binds via its C-terminal region to the N-terminal region of MYC. Associates with AKAP1/S-AKAP84. Interacts with MYCBPAP.
INTERACTION: Q7Z4T9-4:AAT1; NbExp=5; IntAct=EBI-716185, EBI-2119735; Q92667-2:AKAP1; NbExp=2; IntAct=EBI-716185, EBI-2120060; Q9Y6D6:ARFGEF1; NbExp=3; IntAct=EBI-716185, EBI-1044254; Q9Y6D5:ARFGEF2; NbExp=5; IntAct=EBI-716185, EBI-2837511; Q8TBZ2:MYCBPAP; NbExp=4; IntAct=EBI-716185, EBI-1391585;
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Mitochondrion. Note=Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
TISSUE SPECIFICITY: Highly expressed in heart, placenta, pancreas, skeletal muscle and kidney. Also present at low levels in lung.
SIMILARITY: Belongs to the AMY1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 0.57 RPKM in Testis
Total median expression: 0.57 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -16.4043-0.381 Picture PostScript Text
3' UTR -558.802177-0.257 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR026060 - AMY1

SCOP Domains:
58026 - Delta-sleep-inducing peptide immunoreactive peptide

Protein Data Bank (PDB) 3-D Structure
MuPIT help
2YY0 - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q99417
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003713 transcription coactivator activity
GO:0005515 protein binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007283 spermatogenesis

Cellular Component:
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion


-  Descriptions from all associated GenBank mRNAs
  BC044622 - Homo sapiens cDNA clone IMAGE:5275700, **** WARNING: chimeric clone ****.
JD309850 - Sequence 290874 from Patent EP1572962.
AB007191 - Homo sapiens mRNA for AMY-1, complete cds.
JD082338 - Sequence 63362 from Patent EP1572962.
CQ873822 - Sequence 241 from Patent WO2004076622.
DD413659 - Regulation of Mammalian Cells.
JD084584 - Sequence 65608 from Patent EP1572962.
JD562678 - Sequence 543702 from Patent EP1572962.
JD350395 - Sequence 331419 from Patent EP1572962.
JD326323 - Sequence 307347 from Patent EP1572962.
JD300149 - Sequence 281173 from Patent EP1572962.
JD490680 - Sequence 471704 from Patent EP1572962.
BC008686 - Homo sapiens c-myc binding protein, mRNA (cDNA clone MGC:9561 IMAGE:3870100), complete cds.
JD515846 - Sequence 496870 from Patent EP1572962.
JD216186 - Sequence 197210 from Patent EP1572962.
JD436364 - Sequence 417388 from Patent EP1572962.
JD426776 - Sequence 407800 from Patent EP1572962.
JD284038 - Sequence 265062 from Patent EP1572962.
JD146496 - Sequence 127520 from Patent EP1572962.
JD188340 - Sequence 169364 from Patent EP1572962.
JD431552 - Sequence 412576 from Patent EP1572962.
JD363956 - Sequence 344980 from Patent EP1572962.
JD081871 - Sequence 62895 from Patent EP1572962.
DQ579197 - Homo sapiens piRNA piR-47309, complete sequence.
JD538912 - Sequence 519936 from Patent EP1572962.
JD332948 - Sequence 313972 from Patent EP1572962.
JD349270 - Sequence 330294 from Patent EP1572962.
D50692 - Homo sapiens mRNA for c-myc binding protein, complete cds.
BC039090 - Homo sapiens c-myc binding protein, mRNA (cDNA clone IMAGE:5165795).
BC051675 - Homo sapiens gap junction protein, alpha 9, 59kDa, mRNA (cDNA clone IMAGE:5269870).
AK123051 - Homo sapiens cDNA FLJ41056 fis, clone TESTI2003347, highly similar to Gap junction alpha-10 protein.
JD144194 - Sequence 125218 from Patent EP1572962.
JD147500 - Sequence 128524 from Patent EP1572962.
DQ891491 - Synthetic construct Homo sapiens clone IMAGE:100004121; FLH263584.01X; RZPDo839A03126D c-myc binding protein (MYCBP) gene, encodes complete protein.
DQ893698 - Synthetic construct clone IMAGE:100006328; FLH177506.01X; RZPDo839A12126D c-myc binding protein (MYCBP) gene, encodes complete protein.
DQ894690 - Synthetic construct Homo sapiens clone IMAGE:100009150; FLH177502.01L; RZPDo839A12125D c-myc binding protein (MYCBP) gene, encodes complete protein.
BT007109 - Homo sapiens c-myc binding protein mRNA, complete cds.
AK311886 - Homo sapiens cDNA, FLJ92152, highly similar to Homo sapiens c-myc binding protein (MYCBP), mRNA.
KJ893561 - Synthetic construct Homo sapiens clone ccsbBroadEn_02955 MYCBP gene, encodes complete protein.
AB451287 - Homo sapiens MYCBP mRNA for c-myc binding protein, complete cds, clone: FLJ08125AAAN.
AB451419 - Homo sapiens MYCBP mRNA for c-myc binding protein, partial cds, clone: FLJ08125AAAF.
CR456936 - Homo sapiens full open reading frame cDNA clone RZPDo834B0316D for gene MYCBP, c-myc binding protein; complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: AMY1, B2R4N0, ENST00000397572.1, ENST00000397572.2, ENST00000397572.3, ENST00000397572.4, MYCBP , MYCBP_HUMAN, NM_012333, Q5TA64, Q96HE2, Q99417, uc318zcv.1, uc318zcv.2
UCSC ID: ENST00000397572.5_9
RefSeq Accession: NM_012333.5
Protein: Q99417 (aka MYCBP_HUMAN or AMY1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.