ID:MUC21_HUMAN DESCRIPTION: RecName: Full=Mucin-21; Short=MUC-21; AltName: Full=Epiglycanin; Flags: Precursor; SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein; Extracellular side. TISSUE SPECIFICITY: Expressed in lung, large intestine, thymus, and testis. Expressed in normal and malignant bronchial epithelial cells. PTM: O-glycosylated. MISCELLANEOUS: Could be considered as a marker for lung carcinomas. SEQUENCE CAUTION: Sequence=AAI05737.1; Type=Erroneous initiation; Note=Translation N-terminally extended; WEB RESOURCE: Name=Mucin database; URL="http://www.medkem.gu.se/mucinbiology/databases/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
Pfam Domains: PF05647 - Tandem-repeating region of mucin, epiglycanin-like PF14654 - Mucin, catalytic, TM and cytoplasmic tail region
ModBase Predicted Comparative 3D Structure on Q5SSG8
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK299471 - Homo sapiens cDNA FLJ50027 complete cds, weakly similar to Dentin sialophosphoprotein precursor. AK316363 - Homo sapiens cDNA, FLJ79262 complete cds, weakly similar to Dentin sialophosphoprotein precursor. AK298642 - Homo sapiens cDNA FLJ56824 complete cds, weakly similar to Dentin sialophosphoprotein precursor. AY358415 - Homo sapiens clone DNA66674 KMQK697 (UNQ697) mRNA, complete cds. BC105735 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125612 IMAGE:40026480), complete cds. BC105736 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone IMAGE:40026479), complete cds. BC105737 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125610 IMAGE:40026476), complete cds. BC107478 - Homo sapiens mucin 21, cell surface associated, mRNA (cDNA clone MGC:125609 IMAGE:40026469), complete cds. HM596784 - Homo sapiens epiglycanin (MUC21) mRNA, complete cds. AB242595 - Homo sapiens MUC21 mRNA for mucin 21, complete cds. KJ905669 - Synthetic construct Homo sapiens clone ccsbBroadEn_15325 MUC21 gene, encodes complete protein. AK301645 - Homo sapiens cDNA FLJ54412 complete cds, moderately similar to Homo sapiens dentin sialophosphoprotein (DSPP), mRNA. JD371053 - Sequence 352077 from Patent EP1572962. JD321809 - Sequence 302833 from Patent EP1572962. JD321809 - Sequence 302833 from Patent EP1572962. JD371053 - Sequence 352077 from Patent EP1572962. JD321809 - Sequence 302833 from Patent EP1572962. AK056612 - Homo sapiens cDNA FLJ32050 fis, clone NTONG2001222. JD321809 - Sequence 302833 from Patent EP1572962. JD544031 - Sequence 525055 from Patent EP1572962. JD371053 - Sequence 352077 from Patent EP1572962. JD187588 - Sequence 168612 from Patent EP1572962. JD532548 - Sequence 513572 from Patent EP1572962. JD556550 - Sequence 537574 from Patent EP1572962. JD514750 - Sequence 495774 from Patent EP1572962. JD078461 - Sequence 59485 from Patent EP1572962. JD486816 - Sequence 467840 from Patent EP1572962. JD082405 - Sequence 63429 from Patent EP1572962. JD043234 - Sequence 24258 from Patent EP1572962. JD054736 - Sequence 35760 from Patent EP1572962. JD175102 - Sequence 156126 from Patent EP1572962. JD243864 - Sequence 224888 from Patent EP1572962. JD176333 - Sequence 157357 from Patent EP1572962. JD043649 - Sequence 24673 from Patent EP1572962. JD054161 - Sequence 35185 from Patent EP1572962. JD297539 - Sequence 278563 from Patent EP1572962. JD488517 - Sequence 469541 from Patent EP1572962. JD462717 - Sequence 443741 from Patent EP1572962. JD349212 - Sequence 330236 from Patent EP1572962. JD086936 - Sequence 67960 from Patent EP1572962. JD299494 - Sequence 280518 from Patent EP1572962. JD082070 - Sequence 63094 from Patent EP1572962. JD546213 - Sequence 527237 from Patent EP1572962. JD337911 - Sequence 318935 from Patent EP1572962. JD463965 - Sequence 444989 from Patent EP1572962. JD250512 - Sequence 231536 from Patent EP1572962. JD292710 - Sequence 273734 from Patent EP1572962. JD535529 - Sequence 516553 from Patent EP1572962. JD425942 - Sequence 406966 from Patent EP1572962. JD424940 - Sequence 405964 from Patent EP1572962. JD214949 - Sequence 195973 from Patent EP1572962. JD310961 - Sequence 291985 from Patent EP1572962. JD261676 - Sequence 242700 from Patent EP1572962. JD541536 - Sequence 522560 from Patent EP1572962. JD238909 - Sequence 219933 from Patent EP1572962. JD374419 - Sequence 355443 from Patent EP1572962. JD549039 - Sequence 530063 from Patent EP1572962. JD334501 - Sequence 315525 from Patent EP1572962. JD332936 - Sequence 313960 from Patent EP1572962. JD089177 - Sequence 70201 from Patent EP1572962. JD490175 - Sequence 471199 from Patent EP1572962. JD501386 - Sequence 482410 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q5SSG8 (Reactome details) participates in the following event(s):
R-HSA-913675 GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens R-HSA-5694487 A4GNT transfers GlcNAc to core 2 mucins R-HSA-6786012 CHST4 transfers SO4(2-) from PAPS to Core 2 mucins R-HSA-914012 GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins R-HSA-914018 Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein R-HSA-977228 Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position R-HSA-981497 ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position R-HSA-981814 GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position R-HSA-1964505 C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens) R-HSA-1964501 Addition of galactose to Core 6 glycoprotein R-HSA-914010 Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein R-HSA-977071 Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position R-HSA-981809 ST6GALNAC3/4 can add a sialic acid to the sialyl T antigen to form the disialyl T antigen R-HSA-8858500 CLEC10A binds Tn-MUC1 R-HSA-913709 O-linked glycosylation of mucins R-HSA-5083636 Defective GALNT12 causes colorectal cancer 1 (CRCS1) R-HSA-5083625 Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) R-HSA-977068 Termination of O-glycan biosynthesis R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) R-HSA-5621480 Dectin-2 family R-HSA-5173105 O-linked glycosylation R-HSA-3906995 Diseases associated with O-glycosylation of proteins R-HSA-5621481 C-type lectin receptors (CLRs) R-HSA-597592 Post-translational protein modification R-HSA-3781865 Diseases of glycosylation R-HSA-168249 Innate Immune System R-HSA-392499 Metabolism of proteins R-HSA-1643685 Disease R-HSA-168256 Immune System
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
