Human Gene MT4 (ENST00000219162.4_4) from GENCODE V47lift37
  Description: metallothionein 4 (from RefSeq NM_032935.3)
Gencode Transcript: ENST00000219162.4_4
Gencode Gene: ENSG00000102891.4_7
Transcript (Including UTRs)
   Position: hg19 chr16:56,598,985-56,602,869 Size: 3,885 Total Exon Count: 3 Strand: +
Coding Region
   Position: hg19 chr16:56,599,041-56,602,844 Size: 3,804 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr16:56,598,985-56,602,869)mRNA (may differ from genome)Protein (62 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
MGIOMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MT4_HUMAN
DESCRIPTION: RecName: Full=Metallothionein-4; Short=MT-4; AltName: Full=Metallothionein-IV; Short=MT-IV;
FUNCTION: Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.
SIMILARITY: Belongs to the metallothionein superfamily. Type 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 26.08 RPKM in Skin - Sun Exposed (Lower leg)
Total median expression: 45.42 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -8.2056-0.146 Picture PostScript Text
3' UTR 0.00250.000 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR017854 - Metalthion_dom
IPR023587 - Metalthion_dom_vert
IPR003019 - Metalthion_sfam_euk
IPR000006 - Metalthion_vert

Pfam Domains:
PF00131 - Metallothionein

SCOP Domains:
57868 - Metallothionein

ModBase Predicted Comparative 3D Structure on P47944
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGD    
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0046872 metal ion binding

Biological Process:
GO:0006875 cellular metal ion homeostasis
GO:0008150 biological_process

Cellular Component:
GO:0005623 cell


-  Descriptions from all associated GenBank mRNAs
  BC113442 - Homo sapiens metallothionein 4, mRNA (cDNA clone MGC:142002 IMAGE:8322494), complete cds.
BC113444 - Homo sapiens metallothionein 4, mRNA (cDNA clone MGC:142004 IMAGE:8322496), complete cds.
HQ258024 - Synthetic construct Homo sapiens clone IMAGE:100072333 metallothionein 4 (MT4) gene, encodes complete protein.
KJ895008 - Synthetic construct Homo sapiens clone ccsbBroadEn_04402 MT4 gene, encodes complete protein.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P47944 (Reactome details) participates in the following event(s):

R-HSA-5662647 MT4 binds copper
R-HSA-5662649 MT4 binds cadmium
R-HSA-5662653 MT4 binds zinc
R-HSA-5661231 Metallothioneins bind metals
R-HSA-5660526 Response to metal ions
R-HSA-8953897 Cellular responses to external stimuli

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000219162.1, ENST00000219162.2, ENST00000219162.3, MT4_HUMAN, NM_032935, P47944, Q14DA1, uc317cwk.1, uc317cwk.2
UCSC ID: ENST00000219162.4_4
RefSeq Accession: NM_032935.3
Protein: P47944 (aka MT4_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.