Human Gene MRTO4 (ENST00000330263.5_4) from GENCODE V47lift37

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Description: MRT4 homolog, ribosome maturation factor (from RefSeq NM_016183.4)
Gencode Transcript: ENST00000330263.5_4
Gencode Gene: ENSG00000053372.5_8
Transcript (Including UTRs)
Position: hg19 chr1:19,578,299-19,586,622 Size: 8,324 Total Exon Count: 8 Strand: +
Coding Region
Position: hg19 chr1:19,578,330-19,585,324 Size: 6,995 Coding Exon Count: 8

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr1:19,578,299-19,586,622)			mRNA (may differ from genome)		Protein (239 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MRT4_HUMAN DESCRIPTION: RecName: Full=mRNA turnover protein 4 homolog; FUNCTION: Involved in mRNA turnover and ribosome assembly (By similarity). SUBCELLULAR LOCATION: Nucleus, nucleolus. SIMILARITY: Belongs to the ribosomal protein L10P family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D003993 Dibutyl Phthalate D015123 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide D001564 Benzo(a)pyrene D016572 Cyclosporine D004051 Diethylhexyl Phthalate D010634 Phenobarbital D011374 Progesterone D012906 Smoke D012999 Soman more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 28.93 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 620.12 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-6.60	31	-0.213	Picture	PostScript	Text
3' UTR	-566.10	1298	-0.436	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR001790 - Ribosomal_L10/acidic_P0

Pfam Domains:
PF00466 - Ribosomal protein L10
PF17777 - Insertion domain in 60S ribosomal protein L10P

SCOP Domains:
160369 - Ribosomal protein L10-like

ModBase Predicted Comparative 3D Structure on Q9UKD2


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	Genome Browser
Gene Details	Gene Details		Gene Details	Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase	SGD
				Protein Sequence	Protein Sequence
				Alignment	Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0005515 protein binding Biological Process: GO:0000027 ribosomal large subunit assembly GO:0000956 nuclear-transcribed mRNA catabolic process GO:0006364 rRNA processing GO:0042254 ribosome biogenesis Cellular Component: GO:0005622 intracellular GO:0005634 nucleus GO:0005730 nucleolus GO:0005737 cytoplasm

Descriptions from all associated GenBank mRNAs


	LF206694 - JP 2014500723-A/14197: Polycomb-Associated Non-Coding RNAs. AK027569 - Homo sapiens cDNA FLJ14663 fis, clone NT2RP2002862, weakly similar to 60S ACIDIC RIBOSOMAL PROTEIN P0. AF173378 - Homo sapiens 60S acidic ribosomal protein PO mRNA, complete cds. BC003013 - Homo sapiens mRNA turnover 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:4041 IMAGE:2821148), complete cds. BC006504 - Homo sapiens mRNA turnover 4 homolog (S. cerevisiae), mRNA (cDNA clone MGC:2400 IMAGE:2821148), complete cds. AK024227 - Homo sapiens cDNA FLJ14165 fis, clone NT2RP1000746, highly similar to mRNA turnover protein 4 homolog. AY303790 - Homo sapiens acidic ribosomal protein PO-like mRNA, complete cds. AK126387 - Homo sapiens cDNA FLJ44423 fis, clone UTERU2004929. KJ898840 - Synthetic construct Homo sapiens clone ccsbBroadEn_08234 MRTO4 gene, encodes complete protein. AK295328 - Homo sapiens cDNA FLJ57985 complete cds, moderately similar to mRNA turnover protein 4 homolog. LF357175 - JP 2014500723-A/164678: Polycomb-Associated Non-Coding RNAs. JD343016 - Sequence 324040 from Patent EP1572962. JD170697 - Sequence 151721 from Patent EP1572962. JD488035 - Sequence 469059 from Patent EP1572962. LF357174 - JP 2014500723-A/164677: Polycomb-Associated Non-Coding RNAs. JD438277 - Sequence 419301 from Patent EP1572962. LF357173 - JP 2014500723-A/164676: Polycomb-Associated Non-Coding RNAs. JD140108 - Sequence 121132 from Patent EP1572962. JD144650 - Sequence 125674 from Patent EP1572962. JD542687 - Sequence 523711 from Patent EP1572962. JD212653 - Sequence 193677 from Patent EP1572962. JD212652 - Sequence 193676 from Patent EP1572962. JD198029 - Sequence 179053 from Patent EP1572962. JD198028 - Sequence 179052 from Patent EP1572962. JD413319 - Sequence 394343 from Patent EP1572962. JD413318 - Sequence 394342 from Patent EP1572962. JD246800 - Sequence 227824 from Patent EP1572962. JD246802 - Sequence 227826 from Patent EP1572962. JD246804 - Sequence 227828 from Patent EP1572962. JD246805 - Sequence 227829 from Patent EP1572962. JD277875 - Sequence 258899 from Patent EP1572962. JD430359 - Sequence 411383 from Patent EP1572962. JD529493 - Sequence 510517 from Patent EP1572962. JD169794 - Sequence 150818 from Patent EP1572962. JD306432 - Sequence 287456 from Patent EP1572962. JD055296 - Sequence 36320 from Patent EP1572962. JD531857 - Sequence 512881 from Patent EP1572962. JD176516 - Sequence 157540 from Patent EP1572962. JD066731 - Sequence 47755 from Patent EP1572962. JD184047 - Sequence 165071 from Patent EP1572962. JD092608 - Sequence 73632 from Patent EP1572962. JD559989 - Sequence 541013 from Patent EP1572962. JD539776 - Sequence 520800 from Patent EP1572962. JD470338 - Sequence 451362 from Patent EP1572962. JD439068 - Sequence 420092 from Patent EP1572962. JD271887 - Sequence 252911 from Patent EP1572962. JD482605 - Sequence 463629 from Patent EP1572962. MA442271 - JP 2018138019-A/14197: Polycomb-Associated Non-Coding RNAs. MA592752 - JP 2018138019-A/164678: Polycomb-Associated Non-Coding RNAs. MA592751 - JP 2018138019-A/164677: Polycomb-Associated Non-Coding RNAs. MA592750 - JP 2018138019-A/164676: Polycomb-Associated Non-Coding RNAs.

Other Names for This Gene


	Alternate Gene Symbols: B3KNB3, C1orf33, ENST00000330263.1, ENST00000330263.2, ENST00000330263.3, ENST00000330263.4, MRT4, MRT4_HUMAN, NM_016183, Q5TG55, Q96SS6, Q9BPV9, Q9UKD2, uc317sxt.1, uc317sxt.2 UCSC ID: ENST00000330263.5_4 RefSeq Accession: NM_016183.4 Protein: Q9UKD2 (aka MRT4_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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