Human Gene MRPS7 (ENST00000245539.11_4) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein S7 (from RefSeq NM_015971.4)
Gencode Transcript: ENST00000245539.11_4
Gencode Gene: ENSG00000125445.11_8
Transcript (Including UTRs)
Position: hg19 chr17:73,257,960-73,262,457 Size: 4,498 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr17:73,257,982-73,262,004 Size: 4,023 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	MalaCards	CTD
Gene Alleles	RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species
GO Annotations	mRNA Descriptions	Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr17:73,257,960-73,262,457)			mRNA (may differ from genome)		Protein (242 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	Malacards	MGI	OMIM	PubMed	Reactome
UniProtKB	Wikipedia	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RT07_HUMAN DESCRIPTION: RecName: Full=28S ribosomal protein S7, mitochondrial; Short=MRP-S7; Short=S7mt; AltName: Full=bMRP-27a; Short=bMRP27a; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). SIMILARITY: Belongs to the ribosomal protein S7P family.

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

MalaCards Disease Associations


	MalaCards Gene Search: MRPS7 Diseases sorted by gene-association score: syndromic sensorineural deafness due to combined oxidative phosphorylation defect* (350) * = Manually curated disease association

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D000082 Acetaminophen D019328 Buthionine Sulfoximine D019327 Copper Sulfate D003513 Cycloheximide D006820 Hyaluronic Acid D006861 Hydrogen Peroxide D009569 Nitric Oxide D010433 Pentylenetetrazole D013311 Streptozocin more ... click here to view the complete list

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 18.37 RPKM in Heart - Left Ventricle Total median expression: 471.34 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-4.90	22	-0.223	Picture	PostScript	Text
3' UTR	-148.80	453	-0.328	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000235 - Ribosomal_S5/S7
IPR023798 - Ribosomal_S7_dom

Pfam Domains:
PF00177 - Ribosomal protein S7p/S5e

SCOP Domains:
47973 - Ribosomal protein S7

ModBase Predicted Comparative 3D Structure on Q9Y2R9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003723 RNA binding GO:0003729 mRNA binding GO:0003735 structural constituent of ribosome GO:0019843 rRNA binding Biological Process: GO:0000028 ribosomal small subunit assembly GO:0006412 translation GO:0032543 mitochondrial translation GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005763 mitochondrial small ribosomal subunit GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	LF209418 - JP 2014500723-A/16921: Polycomb-Associated Non-Coding RNAs. AK222995 - Homo sapiens mRNA for mitochondrial ribosomal protein S7 variant, clone: HSI07714. BC000241 - Homo sapiens mitochondrial ribosomal protein S7, mRNA (cDNA clone MGC:711 IMAGE:3350465), complete cds. AF077042 - Homo sapiens 30S ribosomal protein S7 homolog mRNA, complete cds. JD227105 - Sequence 208129 from Patent EP1572962. AK313854 - Homo sapiens cDNA, FLJ94483, Homo sapiens mitochondrial ribosomal protein S7 (MRPS7), nucleargene encoding mitochondrial protein, mRNA. JF432776 - Synthetic construct Homo sapiens clone IMAGE:100074020 mitochondrial ribosomal protein S7 (MRPS7) gene, encodes complete protein. KJ898818 - Synthetic construct Homo sapiens clone ccsbBroadEn_08212 MRPS7 gene, encodes complete protein. BC050641 - Homo sapiens mitochondrial ribosomal protein S7, mRNA (cDNA clone IMAGE:6150671). LF328396 - JP 2014500723-A/135899: Polycomb-Associated Non-Coding RNAs. DQ583347 - Homo sapiens piRNA piR-50459, complete sequence. JD231633 - Sequence 212657 from Patent EP1572962. JD525208 - Sequence 506232 from Patent EP1572962. LF328397 - JP 2014500723-A/135900: Polycomb-Associated Non-Coding RNAs. JD210888 - Sequence 191912 from Patent EP1572962. JD259526 - Sequence 240550 from Patent EP1572962. JD279932 - Sequence 260956 from Patent EP1572962. JD172420 - Sequence 153444 from Patent EP1572962. JD186969 - Sequence 167993 from Patent EP1572962. LF328399 - JP 2014500723-A/135902: Polycomb-Associated Non-Coding RNAs. MA563973 - JP 2018138019-A/135899: Polycomb-Associated Non-Coding RNAs. MA563974 - JP 2018138019-A/135900: Polycomb-Associated Non-Coding RNAs. MA563976 - JP 2018138019-A/135902: Polycomb-Associated Non-Coding RNAs. MA444995 - JP 2018138019-A/16921: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q9Y2R9 (Reactome details) participates in the following event(s): R-HSA-5368279 MTIF3 binds 28S ribosomal subunit R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389849 28S subunit:MTIF3 binds MTIF2:GTP, mRNA, and formylMet-tRNA R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: B2R9N5, ENST00000245539.1, ENST00000245539.10, ENST00000245539.2, ENST00000245539.3, ENST00000245539.4, ENST00000245539.5, ENST00000245539.6, ENST00000245539.7, ENST00000245539.8, ENST00000245539.9, NM_015971, Q53GD6, Q9Y2R9, RT07_HUMAN, uc317eqv.1, uc317eqv.2 UCSC ID: ENST00000245539.11_4 RefSeq Accession: NM_015971.4 Protein: Q9Y2R9 (aka RT07_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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