Human Gene MRPL55 (ENST00000336520.8_10) from GENCODE V47lift37
  Description: mitochondrial ribosomal protein L55, transcript variant 5 (from RefSeq NM_181463.3)
Gencode Transcript: ENST00000336520.8_10
Gencode Gene: ENSG00000162910.19_14
Transcript (Including UTRs)
   Position: hg19 chr1:228,294,386-228,297,000 Size: 2,615 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg19 chr1:228,294,461-228,295,961 Size: 1,501 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDGene Alleles
RNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr1:228,294,386-228,297,000)mRNA (may differ from genome)Protein (128 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCMGIOMIMPubMedReactomeUniProtKB
WikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: RM55_HUMAN
DESCRIPTION: RecName: Full=39S ribosomal protein L55, mitochondrial; Short=L55mt; Short=MRP-L55; Flags: Precursor;
SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
SEQUENCE CAUTION: Sequence=CAI23115.1; Type=Erroneous gene model prediction; Sequence=CAI23118.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 24.01 RPKM in Prostate
Total median expression: 749.88 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -117.00276-0.424 Picture PostScript Text
3' UTR -19.2075-0.256 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR018615 - Ribosomal_L55_mit

Pfam Domains:
PF09776 - Mitochondrial ribosomal protein L55

ModBase Predicted Comparative 3D Structure on Q7Z7F7
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome

Biological Process:
GO:0006412 translation
GO:0070125 mitochondrial translational elongation
GO:0070126 mitochondrial translational termination

Cellular Component:
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005762 mitochondrial large ribosomal subunit
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  AY358771 - Homo sapiens clone DNA131658 AAVG5835 (UNQ5835) mRNA, complete cds.
BC052806 - Homo sapiens mitochondrial ribosomal protein L55, mRNA (cDNA clone MGC:61802 IMAGE:5730155), complete cds.
AK056987 - Homo sapiens cDNA FLJ32425 fis, clone SKMUS2000961.
BX647745 - Homo sapiens mRNA; cDNA DKFZp686D1387 (from clone DKFZp686D1387).
HQ448619 - Synthetic construct Homo sapiens clone IMAGE:100072058; CCSB011845_01 mitochondrial ribosomal protein L55 (MRPL55) gene, encodes complete protein.
KJ895444 - Synthetic construct Homo sapiens clone ccsbBroadEn_04838 MRPL55 gene, encodes complete protein.
CU690936 - Synthetic construct Homo sapiens gateway clone IMAGE:100021571 5' read MRPL55 mRNA.
JD141435 - Sequence 122459 from Patent EP1572962.
JD280464 - Sequence 261488 from Patent EP1572962.
JD157713 - Sequence 138737 from Patent EP1572962.
JD157712 - Sequence 138736 from Patent EP1572962.
JD439807 - Sequence 420831 from Patent EP1572962.
JD202071 - Sequence 183095 from Patent EP1572962.
JD376549 - Sequence 357573 from Patent EP1572962.
JD080098 - Sequence 61122 from Patent EP1572962.
JD336815 - Sequence 317839 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q7Z7F7 (Reactome details) participates in the following event(s):

R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000336520.1, ENST00000336520.2, ENST00000336520.3, ENST00000336520.4, ENST00000336520.5, ENST00000336520.6, ENST00000336520.7, NM_181463, Q5TBY3, Q5TBY6, Q6UWI8, Q7Z7F7, RM55_HUMAN, uc317unv.1, uc317unv.2, UNQ5835/PRO19675
UCSC ID: ENST00000336520.8_10
RefSeq Accession: NM_181463.3
Protein: Q7Z7F7 (aka RM55_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.