ID:RM55_HUMAN DESCRIPTION: RecName: Full=39S ribosomal protein L55, mitochondrial; Short=L55mt; Short=MRP-L55; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). SEQUENCE CAUTION: Sequence=CAI23115.1; Type=Erroneous gene model prediction; Sequence=CAI23118.1; Type=Erroneous gene model prediction;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF09776 - Mitochondrial ribosomal protein L55
ModBase Predicted Comparative 3D Structure on Q7Z7F7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AY358771 - Homo sapiens clone DNA131658 AAVG5835 (UNQ5835) mRNA, complete cds. BC052806 - Homo sapiens mitochondrial ribosomal protein L55, mRNA (cDNA clone MGC:61802 IMAGE:5730155), complete cds. AK056987 - Homo sapiens cDNA FLJ32425 fis, clone SKMUS2000961. BX647745 - Homo sapiens mRNA; cDNA DKFZp686D1387 (from clone DKFZp686D1387). HQ448619 - Synthetic construct Homo sapiens clone IMAGE:100072058; CCSB011845_01 mitochondrial ribosomal protein L55 (MRPL55) gene, encodes complete protein. KJ895444 - Synthetic construct Homo sapiens clone ccsbBroadEn_04838 MRPL55 gene, encodes complete protein. CU690936 - Synthetic construct Homo sapiens gateway clone IMAGE:100021571 5' read MRPL55 mRNA. JD141435 - Sequence 122459 from Patent EP1572962. JD280464 - Sequence 261488 from Patent EP1572962. JD157713 - Sequence 138737 from Patent EP1572962. JD157712 - Sequence 138736 from Patent EP1572962. JD439807 - Sequence 420831 from Patent EP1572962. JD202071 - Sequence 183095 from Patent EP1572962. JD376549 - Sequence 357573 from Patent EP1572962. JD080098 - Sequence 61122 from Patent EP1572962. JD336815 - Sequence 317839 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q7Z7F7 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins