Human Gene MRPL53 (ENST00000258105.8_7) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein L53 (from RefSeq NM_053050.5)
Gencode Transcript: ENST00000258105.8_7
Gencode Gene: ENSG00000204822.7_10
Transcript (Including UTRs)
Position: hg19 chr2:74,699,109-74,699,807 Size: 699 Total Exon Count: 3 Strand: -
Coding Region
Position: hg19 chr2:74,699,246-74,699,787 Size: 542 Coding Exon Count: 3

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr2:74,699,109-74,699,807)			mRNA (may differ from genome)		Protein (112 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RM53_HUMAN DESCRIPTION: RecName: Full=39S ribosomal protein L53, mitochondrial; Short=L53mt; Short=MRP-L53; Flags: Precursor; SUBCELLULAR LOCATION: Mitochondrion (By similarity).

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D013749 Tetrachlorodibenzodioxin D014635 Valproic Acid C009505 4,4'-diaminodiphenylmethane D000082 Acetaminophen D001564 Benzo(a)pyrene D002794 Choline D002994 Clofibrate D004997 Ethinyl Estradiol D005492 Folic Acid D006830 Hydralazine D006861 Hydrogen Peroxide D007657 Ketone Bodies D008094 Lithium D008694 Methamphetamine D008715 Methionine C089730 rosiglitazone C012589 trichostatin A

Common Gene Haplotype Alleles


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Microarray Expression Data


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mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-6.00	20	-0.300	Picture	PostScript	Text
3' UTR	-21.90	137	-0.160	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR019716 - Ribosomal_L53_mit

Pfam Domains:
PF10780 - 39S ribosomal protein L53/MRP-L53

SCOP Domains:
52833 - Thioredoxin-like

ModBase Predicted Comparative 3D Structure on Q96EL3


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	Genome Browser	No ortholog
Gene Details	Gene Details		Gene Details	Gene Details
Gene Sorter	Gene Sorter		Gene Sorter	Gene Sorter
	RGD	Ensembl		WormBase
				Protein Sequence
				Alignment

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0005515 protein binding Biological Process: GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005762 mitochondrial large ribosomal subunit GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	KJ895322 - Synthetic construct Homo sapiens clone ccsbBroadEn_04716 MRPL53 gene, encodes complete protein. LF207220 - JP 2014500723-A/14723: Polycomb-Associated Non-Coding RNAs. LF363234 - JP 2014500723-A/170737: Polycomb-Associated Non-Coding RNAs. BC012163 - Homo sapiens mitochondrial ribosomal protein L53, mRNA (cDNA clone MGC:20402 IMAGE:4622995), complete cds. AK075209 - Homo sapiens cDNA FLJ90728 fis, clone PLACE1009735. LF363233 - JP 2014500723-A/170736: Polycomb-Associated Non-Coding RNAs. MA598811 - JP 2018138019-A/170737: Polycomb-Associated Non-Coding RNAs. MA598810 - JP 2018138019-A/170736: Polycomb-Associated Non-Coding RNAs. MA442797 - JP 2018138019-A/14723: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q96EL3 (Reactome details) participates in the following event(s): R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: ENST00000258105.1, ENST00000258105.2, ENST00000258105.3, ENST00000258105.4, ENST00000258105.5, ENST00000258105.6, ENST00000258105.7, NM_053050, Q96EL3, RM53_HUMAN, uc317gbd.1, uc317gbd.2 UCSC ID: ENST00000258105.8_7 RefSeq Accession: NM_053050.5 Protein: Q96EL3 (aka RM53_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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