Human Gene MRPL52 (ENST00000397496.7_7) from GENCODE V47lift37

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Description: mitochondrial ribosomal protein L52, transcript variant 3 (from RefSeq NM_180982.3)
Gencode Transcript: ENST00000397496.7_7
Gencode Gene: ENSG00000172590.18_12
Transcript (Including UTRs)
Position: hg19 chr14:23,299,096-23,304,246 Size: 5,151 Total Exon Count: 5 Strand: +
Coding Region
Position: hg19 chr14:23,299,122-23,303,530 Size: 4,409 Coding Exon Count: 5

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	RNA Structure	Protein Structure	Other Species	GO Annotations	mRNA Descriptions
Pathways	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr14:23,299,096-23,304,246)			mRNA (may differ from genome)		Protein (122 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	OMIM	PubMed	Reactome	UniProtKB
BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: RM52_HUMAN DESCRIPTION: RecName: Full=39S ribosomal protein L52, mitochondrial; Short=L52mt; Short=MRP-L52; Flags: Precursor; SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins (By similarity). SUBCELLULAR LOCATION: Mitochondrion (By similarity). SEQUENCE CAUTION: Sequence=CAD66556.1; Type=Erroneous initiation;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene C009505 4,4'-diaminodiphenylmethane D001564 Benzo(a)pyrene D016572 Cyclosporine D004958 Estradiol D005839 Gentamicins C038541 N-benzyloxycarbonylprolylprolinal D013749 Tetrachlorodibenzodioxin C044887 beta-methylcholine C089730 rosiglitazone

Common Gene Haplotype Alleles


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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 30.59 RPKM in Cells - EBV-transformed lymphocytes Total median expression: 915.62 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
5' UTR	-2.40	26	-0.092	Picture	PostScript	Text
3' UTR	-229.90	716	-0.321	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

Pfam Domains:
PF18699 - Mitoribosomal protein mL52

ModBase Predicted Comparative 3D Structure on Q86TS9


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0003735 structural constituent of ribosome Biological Process: GO:0006412 translation GO:0032543 mitochondrial translation GO:0070125 mitochondrial translational elongation GO:0070126 mitochondrial translational termination Cellular Component: GO:0005739 mitochondrion GO:0005743 mitochondrial inner membrane GO:0005762 mitochondrial large ribosomal subunit GO:0005840 ribosome

Descriptions from all associated GenBank mRNAs


	LF210067 - JP 2014500723-A/17570: Polycomb-Associated Non-Coding RNAs. AK096946 - Homo sapiens cDNA FLJ39627 fis, A-SMINT2001609. JD212023 - Sequence 193047 from Patent EP1572962. AK292011 - Homo sapiens cDNA FLJ76418 complete cds, highly similar to Homo sapiens mitochondrial ribosomal protein L52 (MRPL52), transcript variant 1, mRNA. AK000450 - Homo sapiens cDNA FLJ20443 fis, clone KAT05031. BX248749 - human full-length cDNA 5-PRIME end of clone CS0DE004YH22 of Placenta of Homo sapiens (human). BC055381 - Homo sapiens mitochondrial ribosomal protein L52, mRNA (cDNA clone IMAGE:6739482). BC068070 - Homo sapiens mitochondrial ribosomal protein L52, mRNA (cDNA clone MGC:78604 IMAGE:5458482), complete cds. KJ903697 - Synthetic construct Homo sapiens clone ccsbBroadEn_13091 MRPL52 gene, encodes complete protein. JD191713 - Sequence 172737 from Patent EP1572962. JD476122 - Sequence 457146 from Patent EP1572962. JD192722 - Sequence 173746 from Patent EP1572962. LF334418 - JP 2014500723-A/141921: Polycomb-Associated Non-Coding RNAs. JD371389 - Sequence 352413 from Patent EP1572962. JD501839 - Sequence 482863 from Patent EP1572962. JD082207 - Sequence 63231 from Patent EP1572962. JD309395 - Sequence 290419 from Patent EP1572962. JD185213 - Sequence 166237 from Patent EP1572962. JD399735 - Sequence 380759 from Patent EP1572962. JD331910 - Sequence 312934 from Patent EP1572962. JD342645 - Sequence 323669 from Patent EP1572962. JD552278 - Sequence 533302 from Patent EP1572962. JD556405 - Sequence 537429 from Patent EP1572962. JD071031 - Sequence 52055 from Patent EP1572962. JD275767 - Sequence 256791 from Patent EP1572962. JD208840 - Sequence 189864 from Patent EP1572962. JD547256 - Sequence 528280 from Patent EP1572962. JD547257 - Sequence 528281 from Patent EP1572962. JD240530 - Sequence 221554 from Patent EP1572962. JD144701 - Sequence 125725 from Patent EP1572962. JD283418 - Sequence 264442 from Patent EP1572962. JD472400 - Sequence 453424 from Patent EP1572962. JD048014 - Sequence 29038 from Patent EP1572962. JD428841 - Sequence 409865 from Patent EP1572962. JD502505 - Sequence 483529 from Patent EP1572962. JD037363 - Sequence 18387 from Patent EP1572962. JD308356 - Sequence 289380 from Patent EP1572962. JD308357 - Sequence 289381 from Patent EP1572962. JD325460 - Sequence 306484 from Patent EP1572962. JD152443 - Sequence 133467 from Patent EP1572962. JD152444 - Sequence 133468 from Patent EP1572962. JD125747 - Sequence 106771 from Patent EP1572962. JD408218 - Sequence 389242 from Patent EP1572962. JD395496 - Sequence 376520 from Patent EP1572962. JD408219 - Sequence 389243 from Patent EP1572962. JD446242 - Sequence 427266 from Patent EP1572962. JD447041 - Sequence 428065 from Patent EP1572962. JD177570 - Sequence 158594 from Patent EP1572962. JD362266 - Sequence 343290 from Patent EP1572962. JD045850 - Sequence 26874 from Patent EP1572962. JD512552 - Sequence 493576 from Patent EP1572962. JD097506 - Sequence 78530 from Patent EP1572962. JD050939 - Sequence 31963 from Patent EP1572962. JD365223 - Sequence 346247 from Patent EP1572962. JD148736 - Sequence 129760 from Patent EP1572962. JD250940 - Sequence 231964 from Patent EP1572962. MA445644 - JP 2018138019-A/17570: Polycomb-Associated Non-Coding RNAs. MA569995 - JP 2018138019-A/141921: Polycomb-Associated Non-Coding RNAs.

Biochemical and Signaling Pathways


	Reactome (by CSHL, EBI, and GO) Protein Q86TS9 (Reactome details) participates in the following event(s): R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation) R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA) R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA R-HSA-5368286 Mitochondrial translation initiation R-HSA-5419276 Mitochondrial translation termination R-HSA-5368287 Mitochondrial translation R-HSA-5389840 Mitochondrial translation elongation R-HSA-72766 Translation R-HSA-392499 Metabolism of proteins

Other Names for This Gene


	Alternate Gene Symbols: A6NMQ8, A8MXK5, A8MYI6, ENST00000397496.1, ENST00000397496.2, ENST00000397496.3, ENST00000397496.4, ENST00000397496.5, ENST00000397496.6, G3XCN9, NM_180982, Q6NVH8, Q86TS9, RM52_HUMAN, uc318zbf.1, uc318zbf.2 UCSC ID: ENST00000397496.7_7 RefSeq Accession: NM_180982.3 Protein: Q86TS9 (aka RM52_HUMAN)

Gene Model Information


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Methods, Credits, and Use Restrictions


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