Human Gene MRPL51 (ENST00000229238.5_7) from GENCODE V47lift37 |
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 Sequence and Links to Tools and Databases
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Comments and Description Text from UniProtKB
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ID: RM51_HUMAN
DESCRIPTION: RecName: Full=39S ribosomal protein L51, mitochondrial; Short=L51mt; Short=MRP-L51; AltName: Full=bMRP-64; Short=bMRP64; Flags: Precursor;
SUBUNIT: Component of the mitochondrial ribosome large subunit (39S) which comprises a 16S rRNA and about 50 distinct proteins. Interacts with OXA1L (By similarity).
SUBCELLULAR LOCATION: Mitochondrion (By similarity).
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Primer design for this transcript
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Comparative Toxicogenomics Database (CTD)
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 Common Gene Haplotype Alleles
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Press "+" in the title bar above to open this section.
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RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
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mRNA Secondary Structure of 3' and 5' UTRs
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The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
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Protein Domain and Structure Information
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InterPro Domains: Graphical view of domain structure
IPR019373 - Ribosomal_L51_mit
Pfam Domains:
PF10244 - Mitochondrial ribosomal subunit
ModBase Predicted Comparative 3D Structure on Q4U2R6
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
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Orthologous Genes in Other Species
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Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
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Gene Ontology (GO) Annotations with Structured Vocabulary
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Descriptions from all associated GenBank mRNAs
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BC000191 - Homo sapiens mitochondrial ribosomal protein L51, mRNA (cDNA clone MGC:877 IMAGE:3350421), complete cds.
AF212248 - Homo sapiens CDA09 mRNA, complete cds.
BC014329 - Homo sapiens mitochondrial ribosomal protein L51, mRNA (cDNA clone MGC:22862 IMAGE:4041761), complete cds.
AF151075 - Homo sapiens HSPC241 mRNA, complete cds.
JD204532 - Sequence 185556 from Patent EP1572962.
AB049959 - Homo sapiens bMRP64 mRNA for mitochondrial ribosomal protein bMRP64, complete cds.
KJ893865 - Synthetic construct Homo sapiens clone ccsbBroadEn_03259 MRPL51 gene, encodes complete protein.
JD135264 - Sequence 116288 from Patent EP1572962.
JD196080 - Sequence 177104 from Patent EP1572962.
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Biochemical and Signaling Pathways
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Reactome (by CSHL, EBI, and GO)
Protein Q4U2R6 (Reactome details) participates in the following event(s):
R-HSA-5389839 39S subunit binds 28S subunit:mRNA:fMet-tRNA
R-HSA-5419273 Hydrolysis of GTP and dissociation of 28S and 39S subunits
R-HSA-5389848 TUFM:GTP:aminoacyl-tRNA binds 55S ribosome:mRNA:fMet-tRNA
R-HSA-5389857 Peptide transfer from P-site to A-site (peptide bond formation)
R-HSA-5389842 TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome
R-HSA-5419261 55S ribosome with peptidyl-tRNA in A site binds GFM1:GTP
R-HSA-5419281 MRRF binds 55S ribosome:mRNA:tRNA
R-HSA-5419279 Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)
R-HSA-5419264 MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA
R-HSA-5419277 GFM2:GTP binds 55S ribosome:mRNA:tRNA:MRRF releasing mRNA and tRNA
R-HSA-5368286 Mitochondrial translation initiation
R-HSA-5419276 Mitochondrial translation termination
R-HSA-5368287 Mitochondrial translation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins
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Other Names for This Gene
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Alternate Gene Symbols: CDA09, ENST00000229238.1, ENST00000229238.2, ENST00000229238.3, ENST00000229238.4, HSPC241, MRP64, NM_016497, Q4U2R6, Q96Q57, Q9BQ36, Q9P0N7, RM51_HUMAN, uc317dpu.1, uc317dpu.2
UCSC ID: ENST00000229238.5_7
RefSeq Accession: NM_016497.4
Protein: Q4U2R6
(aka RM51_HUMAN)
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Gene Model Information
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Click here
for a detailed description of the fields of the table above.
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Methods, Credits, and Use Restrictions
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Click here
for details on how this gene model was made and data restrictions if any.
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US Server
