Human Gene MPO (ENST00000225275.4_7) from GENCODE V47lift37
  Description: myeloperoxidase (from RefSeq NM_000250.2)
Gencode Transcript: ENST00000225275.4_7
Gencode Gene: ENSG00000005381.9_12
Transcript (Including UTRs)
   Position: hg19 chr17:56,347,216-56,358,296 Size: 11,081 Total Exon Count: 12 Strand: -
Coding Region
   Position: hg19 chr17:56,348,017-56,358,119 Size: 10,103 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr17:56,347,216-56,358,296)mRNA (may differ from genome)Protein (745 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
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HGNCMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: PERM_HUMAN
DESCRIPTION: RecName: Full=Myeloperoxidase; Short=MPO; EC=1.11.2.2; Contains: RecName: Full=Myeloperoxidase; Contains: RecName: Full=89 kDa myeloperoxidase; Contains: RecName: Full=84 kDa myeloperoxidase; Contains: RecName: Full=Myeloperoxidase light chain; Contains: RecName: Full=Myeloperoxidase heavy chain; Flags: Precursor;
FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity.
CATALYTIC ACTIVITY: Cl(-) + H(2)O(2) + H(+) = HClO + H(2)O.
CATALYTIC ACTIVITY: Cl(-) + H(2)O(2) = HOCl + 2 H(2)O.
COFACTOR: Binds 1 calcium ion per monomer.
COFACTOR: Binds 1 heme B (iron-protoporphyrin IX) group covalently per monomer.
SUBUNIT: Homodimer; disulfide-linked. Each monomer consists of a light and a heavy chain.
SUBCELLULAR LOCATION: Lysosome.
DISEASE: Defects in MPO are the cause of myeloperoxidase deficiency (MPOD) [MIM:254600]. A disorder characterized by decreased myeloperoxidase activity in neutrophils and monocytes that results in disseminated candidiasis.
SIMILARITY: Belongs to the peroxidase family. XPO subfamily.
WEB RESOURCE: Name=MPObase; Note=MPO mutation db; URL="http://bioinf.uta.fi/MPObase/";
WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/mpo/";
WEB RESOURCE: Name=Wikipedia; Note=Myeloperoxidase entry; URL="http://en.wikipedia.org/wiki/Myeloperoxidase";

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
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To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MPO
Diseases sorted by gene-association score: myeloperoxidase deficiency* (1601), alzheimer disease* (228), vasculitis (39), churg-strauss syndrome (36), myeloid sarcoma (35), rapidly progressive glomerulonephritis (35), crescentic glomerulonephritis (27), mononeuritis multiplex (23), chronic maxillary sinusitis (22), pasteurellosis (21), goodpasture syndrome (20), anca-associated vasculitis (19), microscopic polyangiitis (19), acute proliferative glomerulonephritis (18), autoimmune inner ear disease (18), glomerulonephritis (18), mediastinitis (17), wegener granulomatosis (17), colitis (16), mononeuritis of upper limb and mononeuritis multiplex (16), leukostasis (16), maxillary sinusitis (15), bronchitis (15), retina lymphoma (14), pleurisy (14), eosinophil peroxidase deficiency (13), collagenous colitis (13), eosinophilic granulomatosis with polyangiitis (13), acute myeloid leukemia with minimal differentiation (13), inner ear disease (12), ulcerative colitis (11), natural killer cell leukemia (11), acute monocytic leukemia (10), acute biphenotypic leukemia (10), vernal conjunctivitis (10), henoch-schoenlein purpura (10), chronic rhinitis (10), idiopathic edema (10), proctitis (10), polyarteritis nodosa (10), acute pericementitis (9), chronic granulomatous disease (9), pneumonia (9), acute pancreatitis (9), acute leukemia (9), bronchopneumonia (9), mast-cell sarcoma (9), chediak-higashi syndrome (9), lymphoblastic lymphoma (8), bronchiectasis (8), chronic monocytic leukemia (8), acute basophilic leukemia (8), mononeuropathy (8), allergic rhinitis (8), c6 deficiency (8), ischemia (8), acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) (7), aleukemic leukemia cutis (7), extrinsic allergic alveolitis (7), mast cell disease (7), extrahepatic cholestasis (7), appendicitis (7), ileitis (6), immune-complex glomerulonephritis (6), aortitis (6), cholangitis, primary sclerosing (6), hypersensitivity vasculitis (6), megakaryocytic leukemia (6), hydrops, lactic acidosis, and sideroblastic anemia (5), hypersensitivity reaction type iii disease (5), myeloid leukemia (5), monoclonal paraproteinemia (5), dendritic cell tumor (5), inflammatory bowel disease (5), intestinal disease (5), autoinflammation, lipodystrophy, and dermatosis syndrome (5), pulmonary aspergilloma (4), pleural disease (4), poikiloderma with neutropenia (4), ulcerative stomatitis (4), vulvitis (4), leukemia, acute myeloid (4), central nervous system vasculitis (4), carbuncle (4), pericardial mesothelioma (4), ascending cholangitis (4), periodontosis (4), pulmonary hemosiderosis (4), lung disease (4), pericardium cancer (4), multiple cranial nerve palsy (4), epileptic encephalopathy, childhood-onset (4), arteritic anterior ischemic optic neuropathy (4), suppurative cholangitis (4), leukemia, acute lymphoblastic 3 (3), acne (3), cystic fibrosis (3), leukemia, acute lymphoblastic (3), systemic lupus erythematosus (3), leukemia, acute promyelocytic, somatic (2), bone marrow cancer (2), essential thrombocythemia (2), oral cavity cancer (1), colorectal cancer (1), myocardial infarction (1), gastrointestinal system disease (1), respiratory system disease (1), colonic benign neoplasm (1)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 8.88 RPKM in Whole Blood
Total median expression: 32.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -57.20177-0.323 Picture PostScript Text
3' UTR -268.30801-0.335 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR010255 - Haem_peroxidase
IPR002007 - Haem_peroxidase_animal
IPR019791 - Haem_peroxidase_animal_subgr

Pfam Domains:
PF03098 - Animal haem peroxidase

SCOP Domains:
81736 - Group V grass pollen allergen
48113 - Heme-dependent peroxidases

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1CXP - X-ray 1D2V - X-ray 1D5L - X-ray 1D7W - X-ray 1DNU - X-ray 1DNW - X-ray 1MHL - X-ray 1MYP - X-ray 3F9P - X-ray 3ZS0 - X-ray 3ZS1 - X-ray 4DL1 - X-ray


ModBase Predicted Comparative 3D Structure on P05164
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
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-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003682 chromatin binding
GO:0004601 peroxidase activity
GO:0008201 heparin binding
GO:0016491 oxidoreductase activity
GO:0020037 heme binding
GO:0046872 metal ion binding

Biological Process:
GO:0001878 response to yeast
GO:0002149 hypochlorous acid biosynthetic process
GO:0002679 respiratory burst involved in defense response
GO:0006952 defense response
GO:0006979 response to oxidative stress
GO:0007568 aging
GO:0009612 response to mechanical stimulus
GO:0019430 removal of superoxide radicals
GO:0032094 response to food
GO:0032496 response to lipopolysaccharide
GO:0034374 low-density lipoprotein particle remodeling
GO:0042742 defense response to bacterium
GO:0042744 hydrogen peroxide catabolic process
GO:0043066 negative regulation of apoptotic process
GO:0043312 neutrophil degranulation
GO:0044130 negative regulation of growth of symbiont in host
GO:0050832 defense response to fungus
GO:0055114 oxidation-reduction process
GO:1990268 response to gold nanoparticle

Cellular Component:
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005764 lysosome
GO:0030141 secretory granule
GO:0035578 azurophil granule lumen
GO:0042582 azurophil granule
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome


-  Descriptions from all associated GenBank mRNAs
  X04876 - Human mRNA for myeloperoxidase (EC 1.11.1.7).
M19507 - Human myeloperoxidase mRNA, complete cds.
JD060692 - Sequence 41716 from Patent EP1572962.
JD525881 - Sequence 506905 from Patent EP1572962.
JD298783 - Sequence 279807 from Patent EP1572962.
JD455453 - Sequence 436477 from Patent EP1572962.
JD156298 - Sequence 137322 from Patent EP1572962.
JD310021 - Sequence 291045 from Patent EP1572962.
JD074387 - Sequence 55411 from Patent EP1572962.
JD295573 - Sequence 276597 from Patent EP1572962.
BC130476 - Homo sapiens myeloperoxidase, mRNA (cDNA clone MGC:163348 IMAGE:40146507), complete cds.
JD176740 - Sequence 157764 from Patent EP1572962.
JD282500 - Sequence 263524 from Patent EP1572962.
JD220881 - Sequence 201905 from Patent EP1572962.
J02694 - Human myeloperoxidase mRNA, complete cds.
JD449106 - Sequence 430130 from Patent EP1572962.
JD507764 - Sequence 488788 from Patent EP1572962.
JD209591 - Sequence 190615 from Patent EP1572962.
S56200 - myeloperoxidase [human, monocytic leukemia cell line SKM-1, mRNA Partial, 2238 nt].
HQ258645 - Synthetic construct Homo sapiens clone IMAGE:100072675 myeloperoxidase (MPO), nuclear gene encoding mitochondrial protein (MPO) gene, encodes complete protein; nuclear gene for mitochondrial product.
JD176232 - Sequence 157256 from Patent EP1572962.
JD187108 - Sequence 168132 from Patent EP1572962.
JD177008 - Sequence 158032 from Patent EP1572962.
JD484309 - Sequence 465333 from Patent EP1572962.
JD266554 - Sequence 247578 from Patent EP1572962.
JD127115 - Sequence 108139 from Patent EP1572962.
JD390555 - Sequence 371579 from Patent EP1572962.
JD177253 - Sequence 158277 from Patent EP1572962.
JD374136 - Sequence 355160 from Patent EP1572962.
JD510170 - Sequence 491194 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein P05164 (Reactome details) participates in the following event(s):

R-HSA-6798751 Exocytosis of azurophil granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A1L4B8, ENST00000225275.1, ENST00000225275.2, ENST00000225275.3, NM_000250, P05164, PERM_HUMAN, Q14862, Q4PJH5, Q9UCL7, uc317dio.1, uc317dio.2
UCSC ID: ENST00000225275.4_7
RefSeq Accession: NM_000250.2
Protein: P05164 (aka PERM_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.