Human Gene MIER2 (ENST00000264819.7_6) from GENCODE V47lift37

JavaScript is disabled in your web browser

You must have JavaScript enabled in your web browser to use the Genome Browser

Description: MIER family member 2, transcript variant 1 (from RefSeq NM_017550.3)
Gencode Transcript: ENST00000264819.7_6
Gencode Gene: ENSG00000105556.12_11
Transcript (Including UTRs)
Position: hg19 chr19:305,573-344,796 Size: 39,224 Total Exon Count: 14 Strand: -
Coding Region
Position: hg19 chr19:306,690-344,782 Size: 38,093 Coding Exon Count: 14

Page Index	Sequence and Links	UniProtKB Comments	Primers	CTD	Gene Alleles
RNA-Seq Expression	Microarray Expression	RNA Structure	Protein Structure	Other Species	GO Annotations
mRNA Descriptions	Other Names	Model Information	Methods

Data last updated at UCSC: 2024-08-22 23:36:26

Sequence and Links to Tools and Databases

Genomic Sequence (chr19:305,573-344,796)			mRNA (may differ from genome)		Protein (545 aa)
Gene Sorter	Genome Browser	Other Species FASTA	VisiGene	Gene interactions	Table Schema
AlphaFold	BioGPS	Ensembl	Entrez Gene	ExonPrimer	GeneCards
HGNC	MGI	PubMed	UniProtKB	BioGrid CRISPR DB

Comments and Description Text from UniProtKB


	ID: MIER2_HUMAN DESCRIPTION: RecName: Full=Mesoderm induction early response protein 2; Short=Mi-er2; FUNCTION: Transcriptional repressor (By similarity). SUBCELLULAR LOCATION: Nucleus (By similarity). SIMILARITY: Contains 1 ELM2 domain. SIMILARITY: Contains 1 SANT domain. SEQUENCE CAUTION: Sequence=BAA86507.2; Type=Erroneous translation; Note=Wrong choice of frame;

Primer design for this transcript

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3

Comparative Toxicogenomics Database (CTD)


	The following chemicals interact with this gene D000082 Acetaminophen D014635 Valproic Acid C018021 cobaltous chloride C012589 trichostatin A

Common Gene Haplotype Alleles


	Press "+" in the title bar above to open this section.

RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)


	Highest median expression: 29.49 RPKM in Testis Total median expression: 535.77 RPKM View in GTEx track of Genome Browser View at GTEx portal View GTEx Body Map

Microarray Expression Data


	Press "+" in the title bar above to open this section.

mRNA Secondary Structure of 3' and 5' UTRs

Region	Fold Energy	Bases	Energy/Base	Display As
3' UTR	-492.90	1117	-0.441	Picture	PostScript	Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

Protein Domain and Structure Information

InterPro Domains: Graphical view of domain structure
IPR000949 - ELM2_dom
IPR009057 - Homeodomain-like
IPR001005 - SANT/Myb
IPR017884 - SANT_dom

Pfam Domains:
PF01448 - ELM2 domain

SCOP Domains:
46689 - Homeodomain-like

ModBase Predicted Comparative 3D Structure on Q8N344


Front	Top	Side

The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

Orthologous Genes in Other Species

Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.

Mouse	Rat	Zebrafish	D. melanogaster	C. elegans	S. cerevisiae
No ortholog	No ortholog	No ortholog	No ortholog	No ortholog	No ortholog
Gene Details	Gene Details
Gene Sorter	Gene Sorter
	RGD	Ensembl

Gene Ontology (GO) Annotations with Structured Vocabulary


	Molecular Function: GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0003677 DNA binding GO:0004407 histone deacetylase activity GO:0042826 histone deacetylase binding Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter GO:0016575 histone deacetylation Cellular Component: GO:0005634 nucleus GO:0005737 cytoplasm GO:0032991 macromolecular complex

Descriptions from all associated GenBank mRNAs


	AB033019 - Homo sapiens mRNA for KIAA1193 protein, partial cds. BC028203 - Homo sapiens mesoderm induction early response 1, family member 2, mRNA (cDNA clone MGC:40194 IMAGE:5201526), complete cds. JD390631 - Sequence 371655 from Patent EP1572962. JD560279 - Sequence 541303 from Patent EP1572962. JD392653 - Sequence 373677 from Patent EP1572962. JD190037 - Sequence 171061 from Patent EP1572962. JD484576 - Sequence 465600 from Patent EP1572962. JD077276 - Sequence 58300 from Patent EP1572962. JD210984 - Sequence 192008 from Patent EP1572962. JD417127 - Sequence 398151 from Patent EP1572962. JD339828 - Sequence 320852 from Patent EP1572962. JD339539 - Sequence 320563 from Patent EP1572962. JD389759 - Sequence 370783 from Patent EP1572962. JD322627 - Sequence 303651 from Patent EP1572962. JD365588 - Sequence 346612 from Patent EP1572962. JD140985 - Sequence 122009 from Patent EP1572962. JD399286 - Sequence 380310 from Patent EP1572962. JD479744 - Sequence 460768 from Patent EP1572962. JD416774 - Sequence 397798 from Patent EP1572962. JD338055 - Sequence 319079 from Patent EP1572962. JD408858 - Sequence 389882 from Patent EP1572962. JD129190 - Sequence 110214 from Patent EP1572962. JD391787 - Sequence 372811 from Patent EP1572962. JD441704 - Sequence 422728 from Patent EP1572962. JD474770 - Sequence 455794 from Patent EP1572962. JD443349 - Sequence 424373 from Patent EP1572962. JD051412 - Sequence 32436 from Patent EP1572962. JD403428 - Sequence 384452 from Patent EP1572962. JD125865 - Sequence 106889 from Patent EP1572962. JD124877 - Sequence 105901 from Patent EP1572962. JD191908 - Sequence 172932 from Patent EP1572962. JD280023 - Sequence 261047 from Patent EP1572962. KJ902659 - Synthetic construct Homo sapiens clone ccsbBroadEn_12053 MIER2 gene, encodes complete protein. AB587352 - Synthetic construct DNA, clone: pF1KA1193, Homo sapiens MIER2 gene for mesoderm induction early response 1, family member 2, without stop codon, in Flexi system. CU688424 - Synthetic construct Homo sapiens gateway clone IMAGE:100020274 5' read MIER2 mRNA. JD317339 - Sequence 298363 from Patent EP1572962. JD384301 - Sequence 365325 from Patent EP1572962. JD193130 - Sequence 174154 from Patent EP1572962. JD471685 - Sequence 452709 from Patent EP1572962. JD426125 - Sequence 407149 from Patent EP1572962. JD523694 - Sequence 504718 from Patent EP1572962.

Other Names for This Gene


	Alternate Gene Symbols: ENST00000264819.1, ENST00000264819.2, ENST00000264819.3, ENST00000264819.4, ENST00000264819.5, ENST00000264819.6, KIAA1193, MIER2_HUMAN, NM_017550, Q8N344, Q9ULM7, uc317hvt.1, uc317hvt.2 UCSC ID: ENST00000264819.7_6 RefSeq Accession: NM_017550.3 Protein: Q8N344 (aka MIER2_HUMAN)

Gene Model Information


	Click here for a detailed description of the fields of the table above.

Methods, Credits, and Use Restrictions


	Click here for details on how this gene model was made and data restrictions if any.