ID:MICA3_HUMAN DESCRIPTION: RecName: Full=Protein-methionine sulfoxide oxidase MICAL3; EC=1.14.13.-; AltName: Full=Molecule interacting with CasL protein 3; Short=MICAL-3; FUNCTION: Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization (By similarity). Involved in exocytic vesicles tethering and fusion: the monooxygenase activity is required for this process. CATALYTIC ACTIVITY: [protein]-methionine + NADPH + O(2) = [protein]-methionine-sulfoxide + NADP(+) + H(2)O. COFACTOR: FAD (By similarity). SUBUNIT: Interacts with RAB1B. Interacts with ERC1 and RAB8A. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the Mical family. SIMILARITY: Contains 1 CH (calponin-homology) domain. SIMILARITY: Contains 1 LIM zinc-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7RTP6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003779 actin binding GO:0004497 monooxygenase activity GO:0005515 protein binding GO:0016491 oxidoreductase activity GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0046872 metal ion binding GO:0071949 FAD binding
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
