ID:MESP1_HUMAN DESCRIPTION: RecName: Full=Mesoderm posterior protein 1; AltName: Full=Class C basic helix-loop-helix protein 5; Short=bHLHc5; FUNCTION: Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity). SUBCELLULAR LOCATION: Nucleus (Probable). MISCELLANEOUS: The N- and C-terminal domains are separated by a 2- repeat G-Q region. SIMILARITY: Contains 1 bHLH (basic helix-loop-helix) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9BRJ9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0035326 enhancer binding GO:0044212 transcription regulatory region DNA binding GO:0046983 protein dimerization activity
Biological Process: GO:0001707 mesoderm formation GO:0001756 somitogenesis GO:0001947 heart looping GO:0003007 heart morphogenesis GO:0003139 secondary heart field specification GO:0003143 embryonic heart tube morphogenesis GO:0003210 cardiac atrium formation GO:0003211 cardiac ventricle formation GO:0003236 sinus venosus morphogenesis GO:0003241 growth involved in heart morphogenesis GO:0003259 cardioblast anterior-lateral migration GO:0003260 cardioblast migration GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006366 transcription from RNA polymerase II promoter GO:0007219 Notch signaling pathway GO:0007275 multicellular organism development GO:0007369 gastrulation GO:0008078 mesodermal cell migration GO:0009880 embryonic pattern specification GO:0022008 neurogenesis GO:0023019 signal transduction involved in regulation of gene expression GO:0035481 positive regulation of Notch signaling pathway involved in heart induction GO:0042662 negative regulation of mesodermal cell fate specification GO:0042664 negative regulation of endodermal cell fate specification GO:0045446 endothelial cell differentiation GO:0045747 positive regulation of Notch signaling pathway GO:0045892 negative regulation of transcription, DNA-templated GO:0045893 positive regulation of transcription, DNA-templated GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0048368 lateral mesoderm development GO:0051155 positive regulation of striated muscle cell differentiation GO:0055007 cardiac muscle cell differentiation GO:0060913 cardiac cell fate determination GO:0060921 sinoatrial node cell differentiation GO:0060947 cardiac vascular smooth muscle cell differentiation GO:0060975 cardioblast migration to the midline involved in heart field formation GO:0070368 positive regulation of hepatocyte differentiation GO:0090082 positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
