ID:MED28_HUMAN DESCRIPTION: RecName: Full=Mediator of RNA polymerase II transcription subunit 28; AltName: Full=Endothelial-derived protein 1; AltName: Full=Mediator complex subunit 28; AltName: Full=Merlin and Grb2-interacting cytoskeletal protein; Short=Magicin; AltName: Full=Tumor angiogenesis marker EG-1; FUNCTION: Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways. SUBUNIT: Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Forms a ternary complex with NF2/merlin and GRB2. Binds to actin. INTERACTION: P06241:FYN; NbExp=5; IntAct=EBI-514199, EBI-515315; P62993:GRB2; NbExp=3; IntAct=EBI-514199, EBI-401755; P06239:LCK; NbExp=4; IntAct=EBI-514199, EBI-1348; P35240:NF2; NbExp=4; IntAct=EBI-514199, EBI-1014472; P35240-1:NF2; NbExp=2; IntAct=EBI-514199, EBI-1014500; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Membrane; Peripheral membrane protein. Note=According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated. TISSUE SPECIFICITY: Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver. INDUCTION: Up-regulated by endothelial cells when exposed to tumor conditional media. SIMILARITY: Belongs to the Mediator complex subunit 28 family. SEQUENCE CAUTION: Sequence=AAK11563.1; Type=Frameshift; Positions=165;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9H204
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
