ID:MDHM_HUMAN DESCRIPTION: RecName: Full=Malate dehydrogenase, mitochondrial; EC=1.1.1.37; Flags: Precursor; CATALYTIC ACTIVITY: (S)-malate + NAD(+) = oxaloacetate + NADH. ENZYME REGULATION: Enzyme activity is enhanced by acetylation. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Mitochondrion matrix. PTM: Acetylation is enhanced by up to 67% after treatment either with trichostin A (TSA) or with nicotinamide (NAM) with the appearance of tri-and tetraacetylations. Glucose also increases acetylation by about 60% (By similarity). SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family. WEB RESOURCE: Name=Wikipedia; Note=Malate dehydrogenase entry; URL="http://en.wikipedia.org/wiki/Malate_dehydrogenase";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P40926
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF047470 - Homo sapiens malate dehydrogenase precursor (MDH) mRNA, nuclear gene encoding mitochondrial protein, complete cds. HM005433 - Homo sapiens clone HTL-T-120 testicular tissue protein Li 120 mRNA, complete cds. AK290779 - Homo sapiens cDNA FLJ75674 complete cds, highly similar to Homo sapiens malate dehydrogenase 2, NAD (mitochondrial) (MDH2), mRNA. AK095803 - Homo sapiens cDNA FLJ38484 fis, clone FEBRA2023227, highly similar to MALATE DEHYDROGENASE, MITOCHONDRIAL PRECURSOR (EC 1.1.1.37). BC001917 - Homo sapiens malate dehydrogenase 2, NAD (mitochondrial), mRNA (cDNA clone MGC:3559 IMAGE:2823443), complete cds. AK316587 - Homo sapiens cDNA, FLJ95392, highly similar to Homo sapiens malate dehydrogenase 2, NAD (mitochondrial) (MDH2), mRNA. DQ893080 - Synthetic construct clone IMAGE:100005710; FLH193462.01X; RZPDo839G0678D malate dehydrogenase 2, NAD (mitochondrial) (MDH2) gene, encodes complete protein. DQ896341 - Synthetic construct Homo sapiens clone IMAGE:100010801; FLH193458.01L; RZPDo839G0668D malate dehydrogenase 2, NAD (mitochondrial) (MDH2) gene, encodes complete protein. KJ897180 - Synthetic construct Homo sapiens clone ccsbBroadEn_06574 MDH2 gene, encodes complete protein. CR536548 - Homo sapiens full open reading frame cDNA clone RZPDo834E0920D for gene MDH2, malate dehydrogenase 2, NAD (mitochondrial); complete cds, incl. stopcodon. AK293460 - Homo sapiens cDNA FLJ52880 complete cds, highly similar to Malate dehydrogenase, mitochondrial precursor (EC 1.1.1.37). JD021505 - Sequence 2529 from Patent EP1572962. JD035704 - Sequence 16728 from Patent EP1572962. DQ402957 - Homo sapiens mitochondrial malate dehydrogenase 2, NAD (MDH2) mRNA, partial cds; nuclear gene for mitochondrial product. DQ576321 - Homo sapiens piRNA piR-44433, complete sequence. JD026703 - Sequence 7727 from Patent EP1572962. JD034315 - Sequence 15339 from Patent EP1572962. JD025363 - Sequence 6387 from Patent EP1572962. JD028448 - Sequence 9472 from Patent EP1572962. JD296415 - Sequence 277439 from Patent EP1572962. JD378299 - Sequence 359323 from Patent EP1572962.
Biochemical and Signaling Pathways
BioCyc Knowledge Library MALATE-ASPARTATE-SHUTTLE-PWY - malate-aspartate shuttle PWY66-398 - TCA cycle PWY66-399 - gluconeogenesis PWY66-407 - superpathway of conversion of glucose to acetyl CoA and entry into the TCA cycle
Reactome (by CSHL, EBI, and GO)
Protein P40926 (Reactome details) participates in the following event(s):
R-HSA-70979 (S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+ R-HSA-71783 Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+ R-HSA-71403 Citric acid cycle (TCA cycle) R-HSA-70263 Gluconeogenesis R-HSA-71406 Pyruvate metabolism and Citric Acid (TCA) cycle R-HSA-70326 Glucose metabolism R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport R-HSA-71387 Metabolism of carbohydrates R-HSA-1430728 Metabolism
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
