ID:MDFI_HUMAN DESCRIPTION: RecName: Full=MyoD family inhibitor; AltName: Full=Myogenic repressor I-mf; FUNCTION: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). SUBUNIT: The C-terminus interacts with AXIN1 and LEF1 (By similarity). INTERACTION: P29972:AQP1; NbExp=4; IntAct=EBI-724076, EBI-745213; P55064:AQP5; NbExp=3; IntAct=EBI-724076, EBI-746103; Q5T681:C10orf62; NbExp=4; IntAct=EBI-724076, EBI-744052; Q96EN9:C19orf60; NbExp=3; IntAct=EBI-724076, EBI-745810; Q96LL4:C8orf48; NbExp=3; IntAct=EBI-724076, EBI-751596; O43439:CBFA2T2; NbExp=3; IntAct=EBI-724076, EBI-748628; Q14781:CBX2; NbExp=3; IntAct=EBI-724076, EBI-745934; Q8NE01:CNNM3; NbExp=3; IntAct=EBI-724076, EBI-741032; Q5TAQ9:DCAF8; NbExp=3; IntAct=EBI-724076, EBI-740686; O94907:DKK1; NbExp=3; IntAct=EBI-724076, EBI-742864; Q9H5Z6:FAM124B; NbExp=4; IntAct=EBI-724076, EBI-741626; P04899:GNAI2; NbExp=2; IntAct=EBI-724076, EBI-353997; P17482:HOXB9; NbExp=3; IntAct=EBI-724076, EBI-745290; Q14847:LASP1; NbExp=3; IntAct=EBI-724076, EBI-742828; O75427:LRCH4; NbExp=3; IntAct=EBI-724076, EBI-718707; Q8WWR8:NEU4; NbExp=3; IntAct=EBI-724076, EBI-746964; P55055:NR1H2; NbExp=3; IntAct=EBI-724076, EBI-745354; Q3YEC7:PARF; NbExp=2; IntAct=EBI-724076, EBI-742029; Q8WV24:PHLDA1; NbExp=3; IntAct=EBI-724076, EBI-738731; Q9HB75:PIDD; NbExp=3; IntAct=EBI-724076, EBI-520427; Q15475:SIX1; NbExp=2; IntAct=EBI-724076, EBI-743675; Q9UBX3:SLC25A10; NbExp=3; IntAct=EBI-724076, EBI-750394; Q9P2T0:THEG; NbExp=3; IntAct=EBI-724076, EBI-751020; O43167:ZBTB24; NbExp=3; IntAct=EBI-724076, EBI-744471; P24278:ZBTB25; NbExp=2; IntAct=EBI-724076, EBI-739899; P52737:ZNF136; NbExp=3; IntAct=EBI-724076, EBI-749129; Q9H9D4:ZNF408; NbExp=3; IntAct=EBI-724076, EBI-347633; O15015:ZNF646; NbExp=3; IntAct=EBI-724076, EBI-745608; SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm (By similarity). SIMILARITY: Belongs to the MDFI family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q99750
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
