ID:MCM10_HUMAN DESCRIPTION: RecName: Full=Protein MCM10 homolog; Short=HsMCM10; FUNCTION: Acts as a replication initiation factor that brings together the MCM2-7 helicase and the DNA polymerase alpha/primase complex in order to initiate DNA replication. Additionally, plays a role in preventing DNA damage during replication. SUBUNIT: Self-associates (By similarity). Interacts with ORC2. May interact with MCM2 and MCM6. Interacts with the DNA polymerase alpha subunit POLA1. Interacts with RECQL4; this interaction regulates RECQL4 unwinding activity. Interacts with WDHD1. INTERACTION: Q14566:MCM6; NbExp=2; IntAct=EBI-374912, EBI-374900; Q13416:ORC2; NbExp=5; IntAct=EBI-374912, EBI-374957; SUBCELLULAR LOCATION: Nucleus. Note=Colocalizes with ORC2 in nuclei foci. Associated with chromatin in S phase. From early to mid-S phase located in discrete nuclear foci. In early S phase, several hundred foci appeared throughout the nucleus. In mid-S phase, the foci appeared at the nuclear periphery and nucleolar regions. In the late S and G phases localized to nucleoli. DEVELOPMENTAL STAGE: Expression is cell cycle regulated. Expression increases at the G1/S-boundary. Expression decreases in late M phase, remains low during G(1) phase, and starts to accumulate at the onset of S phase. DOMAIN: Each zinc finger-like domain binds a zinc ion and is involved in both ssDNA and dsDNA binding, as is the OB-fold domain (By similarity). DOMAIN: The N-terminal domain mediates homodimerization (By similarity). PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the MCM10 family. SEQUENCE CAUTION: Sequence=AAF69623.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q7L590
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK292701 - Homo sapiens cDNA FLJ77264 complete cds, highly similar to Homo sapiens MCM10 minichromosome maintenance deficient 10 (MCM10), transcript variant 1, mRNA. AK055695 - Homo sapiens cDNA FLJ31133 fis, clone IMR322000973, weakly similar to DNA43 PROTEIN. BC101727 - Homo sapiens minichromosome maintenance complex component 10, mRNA (cDNA clone MGC:126776 IMAGE:8069233), complete cds. AB042719 - Homo sapiens mRNA for MCM10 homolog, complete cds. AL136840 - Homo sapiens mRNA; cDNA DKFZp434H152 (from clone DKFZp434H152). BC143490 - Homo sapiens minichromosome maintenance complex component 10, mRNA (cDNA clone MGC:177015 IMAGE:9051998), complete cds. BC009108 - Homo sapiens cDNA clone IMAGE:3451214. BC004876 - Homo sapiens minichromosome maintenance complex component 10, mRNA (cDNA clone IMAGE:3688557), partial cds. AF119869 - Homo sapiens PRO2249 mRNA, complete cds. KJ902823 - Synthetic construct Homo sapiens clone ccsbBroadEn_12217 MCM10 gene, encodes complete protein. JD359378 - Sequence 340402 from Patent EP1572962. JD281188 - Sequence 262212 from Patent EP1572962. JD134508 - Sequence 115532 from Patent EP1572962. DQ599364 - Homo sapiens piRNA piR-37430, complete sequence. JD082771 - Sequence 63795 from Patent EP1572962. JD311085 - Sequence 292109 from Patent EP1572962. JD092800 - Sequence 73824 from Patent EP1572962. JD490293 - Sequence 471317 from Patent EP1572962. JD063534 - Sequence 44558 from Patent EP1572962. JD326754 - Sequence 307778 from Patent EP1572962. JD101351 - Sequence 82375 from Patent EP1572962. JD324016 - Sequence 305040 from Patent EP1572962. JD147111 - Sequence 128135 from Patent EP1572962. JD090014 - Sequence 71038 from Patent EP1572962. JD546547 - Sequence 527571 from Patent EP1572962. JD492138 - Sequence 473162 from Patent EP1572962. JD246316 - Sequence 227340 from Patent EP1572962. JD246317 - Sequence 227341 from Patent EP1572962. JD535556 - Sequence 516580 from Patent EP1572962. JD425896 - Sequence 406920 from Patent EP1572962. JD278402 - Sequence 259426 from Patent EP1572962. JD325197 - Sequence 306221 from Patent EP1572962. JD554346 - Sequence 535370 from Patent EP1572962. JD251543 - Sequence 232567 from Patent EP1572962. JD289463 - Sequence 270487 from Patent EP1572962. JD091097 - Sequence 72121 from Patent EP1572962. JD317652 - Sequence 298676 from Patent EP1572962. JD165786 - Sequence 146810 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q7L590 (Reactome details) participates in the following event(s):
R-HSA-68919 Mcm10 associates with the pre-replicative complex, stabilizing Mcm2-7 R-HSA-68940 Cdt1 is displaced from the pre-replicative complex. R-HSA-68918 CDK and DDK associate with the Mcm10:pre-replicative complex R-HSA-68917 Cdc45 associates with the pre-replicative complex at the origin R-HSA-68916 DNA Replication Factor A (RPA) associates with the pre-replicative complex at the origin R-HSA-176318 Loading of claspin onto DNA during replication origin firing R-HSA-176298 Activation of claspin R-HSA-68962 Activation of the pre-replicative complex R-HSA-69002 DNA Replication Pre-Initiation R-HSA-69206 G1/S Transition R-HSA-68874 M/G1 Transition R-HSA-453279 Mitotic G1-G1/S phases R-HSA-176187 Activation of ATR in response to replication stress R-HSA-69278 Cell Cycle (Mitotic) R-HSA-69306 DNA Replication R-HSA-69481 G2/M Checkpoints R-HSA-1640170 Cell Cycle R-HSA-69620 Cell Cycle Checkpoints
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
