Human Gene MCHR2 (ENST00000281806.7_6) from GENCODE V47lift37
  Description: melanin concentrating hormone receptor 2, transcript variant 2 (from RefSeq NM_032503.3)
Gencode Transcript: ENST00000281806.7_6
Gencode Gene: ENSG00000152034.11_8
Transcript (Including UTRs)
   Position: hg19 chr6:100,366,395-100,442,099 Size: 75,705 Total Exon Count: 6 Strand: -
Coding Region
   Position: hg19 chr6:100,368,816-100,404,023 Size: 35,208 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:100,366,395-100,442,099)mRNA (may differ from genome)Protein (340 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGeneCardsHGNC
Human Cortex Gene ExpressionMalacardsMGIOMIMPubMedReactome
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MCHR2_HUMAN
DESCRIPTION: RecName: Full=Melanin-concentrating hormone receptor 2; Short=MCH receptor 2; Short=MCH-R2; Short=MCHR-2; AltName: Full=G-protein coupled receptor 145; AltName: Full=GPRv17; AltName: Full=MCH-2R; Short=MCH2; Short=MCH2R;
FUNCTION: Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Specifically expressed in the brain, with highest levels in cerebral cortex, hippocampus and amygdala. No expression detected in the cerebellum, thalamus or hypothalamus.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MCHR2
Diseases sorted by gene-association score: peach allergy (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 2.42 RPKM in Brain - Frontal Cortex (BA9)
Total median expression: 8.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -127.40315-0.404 Picture PostScript Text
3' UTR -582.902421-0.241 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR008362 - MCH2_receptor
IPR008361 - MCH_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx
PF10323 - Serpentine type 7TM GPCR chemoreceptor Srv

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q969V1
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0008528 G-protein coupled peptide receptor activity

Biological Process:
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK123634 - Homo sapiens cDNA FLJ41640 fis, clone FEBRA2006890, highly similar to Melanin-concentrating hormone receptor 2.
LP896428 - Sequence 1292 from Patent EP3253886.
AF347063 - Homo sapiens G protein-coupled receptor MCH2 mRNA, complete cds.
AB058849 - Homo sapiens mRNA for GPRv17, complete cds.
AF399937 - Homo sapiens melanin-concentrating hormone receptor MCH-R2 mRNA, complete cds.
AY029596 - Homo sapiens melanin-concentrating hormone 2 receptor mRNA, complete cds.
AY562946 - Homo sapiens melanin-concentrating hormone receptor 2 (MCHR2) mRNA, complete cds.
BC095515 - Homo sapiens melanin-concentrating hormone receptor 2, mRNA (cDNA clone MGC:111729 IMAGE:6971912), complete cds.
AB060151 - Homo sapiens slt mRNA for G protein-coupled receptor, complete cds.
BC038441 - Homo sapiens melanin-concentrating hormone receptor 2, mRNA (cDNA clone IMAGE:5243616), with apparent retained intron.
JD401804 - Sequence 382828 from Patent EP1572962.
JD370878 - Sequence 351902 from Patent EP1572962.
JD296265 - Sequence 277289 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q969V1 (Reactome details) participates in the following event(s):

R-HSA-947673 Melanin-concentrating hormone receptors bind MCH
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-372790 Signaling by GPCR
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B3KVW4, E1P5D7, ENST00000281806.1, ENST00000281806.2, ENST00000281806.3, ENST00000281806.4, ENST00000281806.5, ENST00000281806.6, GPR145, MCHR2_HUMAN, NM_032503, Q5VTV7, Q6Q377, Q969V1, Q9BXA8, SLT, uc317jxg.1, uc317jxg.2
UCSC ID: ENST00000281806.7_6
RefSeq Accession: NM_001040179.2
Protein: Q969V1 (aka MCHR2_HUMAN or MCR2_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.