Human Gene MCHR1 (ENST00000249016.5_6) from GENCODE V47lift37
  Description: melanin concentrating hormone receptor 1 (from RefSeq NM_005297.4)
Gencode Transcript: ENST00000249016.5_6
Gencode Gene: ENSG00000128285.5_7
Transcript (Including UTRs)
   Position: hg19 chr22:41,075,488-41,078,816 Size: 3,329 Total Exon Count: 2 Strand: +
Coding Region
   Position: hg19 chr22:41,075,657-41,077,932 Size: 2,276 Coding Exon Count: 2 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
Gene AllelesRNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther Species
GO AnnotationsmRNA DescriptionsPathwaysOther NamesModel InformationMethods
Data last updated at UCSC: 2024-08-22 23:36:26

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:41,075,488-41,078,816)mRNA (may differ from genome)Protein (353 aa)
Gene SorterGenome BrowserOther Species FASTAVisiGeneGene interactionsTable Schema
AlphaFoldBioGPSEnsemblEntrez GeneExonPrimerGeneCards
HGNCHuman Cortex Gene ExpressionMalacardsMGIOMIMPubMed
ReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: MCHR1_HUMAN
DESCRIPTION: RecName: Full=Melanin-concentrating hormone receptor 1; Short=MCH receptor 1; Short=MCH-R1; Short=MCHR-1; AltName: Full=G-protein coupled receptor 24; AltName: Full=MCH-1R; Short=MCH1R; Short=MCHR; AltName: Full=SLC-1; AltName: Full=Somatostatin receptor-like protein;
FUNCTION: Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
SUBUNIT: Interacts with NCDN.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.
SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CAUTION: It is uncertain whether Met-1, Met-6 or Met-70 is the initiator.
SEQUENCE CAUTION: Sequence=AAC14587.1; Type=Erroneous gene model prediction;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MCHR1
Diseases sorted by gene-association score: vitiligo-associated multiple autoimmune disease susceptibility 1 (7), hypotrichosis 1 (6), obesity (2), bardet-biedl syndrome (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Common Gene Haplotype Alleles
  Press "+" in the title bar above to open this section.

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.81 RPKM in Brain - Cortex
Total median expression: 28.83 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -78.70169-0.466 Picture PostScript Text
3' UTR -302.00884-0.342 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000276 - 7TM_GPCR_Rhodpsn
IPR017452 - GPCR_Rhodpsn_supfam
IPR004047 - MCH1_rcpt
IPR008361 - MCH_rcpt

Pfam Domains:
PF00001 - 7 transmembrane receptor (rhodopsin family)
PF10320 - Serpentine type 7TM GPCR chemoreceptor Srsx

SCOP Domains:
81321 - Family A G protein-coupled receptor-like

ModBase Predicted Comparative 3D Structure on Q99705
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene DetailsGene Details    
Gene SorterGene Sorter    
 RGDEnsembl   
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0004871 signal transducer activity
GO:0004930 G-protein coupled receptor activity
GO:0005102 receptor binding
GO:0008022 protein C-terminus binding
GO:0008188 neuropeptide receptor activity
GO:0030273 melanin-concentrating hormone receptor activity
GO:0042562 hormone binding

Biological Process:
GO:0006091 generation of precursor metabolites and energy
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007218 neuropeptide signaling pathway
GO:0007268 chemical synaptic transmission
GO:0007631 feeding behavior
GO:0051928 positive regulation of calcium ion transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0060170 ciliary membrane
GO:0097730 non-motile cilium


-  Descriptions from all associated GenBank mRNAs
  AK314857 - Homo sapiens cDNA, FLJ95756, Homo sapiens G protein-coupled receptor 24 (GPR24), mRNA.
LF212618 - JP 2014500723-A/20121: Polycomb-Associated Non-Coding RNAs.
AF490537 - Homo sapiens G protein-coupled receptor 24 (GPR24) mRNA, complete cds.
BC001736 - Homo sapiens melanin-concentrating hormone receptor 1, mRNA (cDNA clone MGC:3221 IMAGE:3503484), complete cds.
BC021146 - Homo sapiens melanin-concentrating hormone receptor 1, mRNA (cDNA clone MGC:32129 IMAGE:4890530), complete cds.
AY745811 - Homo sapiens G-protein coupled receptor 24 isoform 2 (GPR24) mRNA, complete cds, alternatively spliced.
AY747629 - Homo sapiens G-protein coupled receptor 24 isoform 1 (GPR24) mRNA, complete cds, alternatively spliced.
LF210374 - JP 2014500723-A/17877: Polycomb-Associated Non-Coding RNAs.
CR456497 - Homo sapiens GPR24 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.GPR24).
AB063174 - Homo sapiens SLC-1 mRNA for somatostatin receptor-like protein, complete cds.
CU013382 - Homo sapiens MCHR1, mRNA (cDNA clone IMAGE:100000257), complete cds, without stop codon, in Gateway system.
KJ896921 - Synthetic construct Homo sapiens clone ccsbBroadEn_06315 MCHR1 gene, encodes complete protein.
KR709783 - Synthetic construct Homo sapiens clone CCSBHm_00006044 MCHR1 (MCHR1) mRNA, encodes complete protein.
CU013094 - Homo sapiens MCHR1, mRNA (cDNA clone IMAGE:100000353), complete cds, with stop codon, in Gateway system.
AB463112 - Synthetic construct DNA, clone: pF1KB5188, Homo sapiens MCHR1 gene for melanin-concentrating hormone receptor 1, without stop codon, in Flexi system.
BT006725 - Homo sapiens G protein-coupled receptor 24 mRNA, complete cds.
DQ893603 - Synthetic construct clone IMAGE:100006233; FLH180860.01X; RZPDo839G10134D melanin-concentrating hormone receptor 1 (MCHR1) gene, encodes complete protein.
DQ895065 - Synthetic construct Homo sapiens clone IMAGE:100009525; FLH180856.01L; RZPDo839G10133D melanin-concentrating hormone receptor 1 (MCHR1) gene, encodes complete protein.
AY562945 - Homo sapiens melanin-concentrating hormone receptor 1 (MCHR1) mRNA, complete cds.
AK308739 - Homo sapiens cDNA, FLJ98780.
JD323216 - Sequence 304240 from Patent EP1572962.
JD163658 - Sequence 144682 from Patent EP1572962.
JD046581 - Sequence 27605 from Patent EP1572962.
JD053767 - Sequence 34791 from Patent EP1572962.
JD140512 - Sequence 121536 from Patent EP1572962.
JD214311 - Sequence 195335 from Patent EP1572962.
JD396209 - Sequence 377233 from Patent EP1572962.
JD253760 - Sequence 234784 from Patent EP1572962.
JD361860 - Sequence 342884 from Patent EP1572962.
JD074400 - Sequence 55424 from Patent EP1572962.
JD502868 - Sequence 483892 from Patent EP1572962.
JD449625 - Sequence 430649 from Patent EP1572962.
JD252762 - Sequence 233786 from Patent EP1572962.
JD564701 - Sequence 545725 from Patent EP1572962.
JD433760 - Sequence 414784 from Patent EP1572962.
JD271512 - Sequence 252536 from Patent EP1572962.
MA448195 - JP 2018138019-A/20121: Polycomb-Associated Non-Coding RNAs.
MA445951 - JP 2018138019-A/17877: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q99705 (Reactome details) participates in the following event(s):

R-HSA-947673 Melanin-concentrating hormone receptors bind MCH
R-HSA-5624126 ARL6:GTP and the BBSome bind ciliary cargo
R-HSA-749454 The Ligand:GPCR:Gi complex dissociates
R-HSA-749452 The Ligand:GPCR:Gq complex dissociates
R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi
R-HSA-749448 Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi
R-HSA-379048 Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
R-HSA-375276 Peptide ligand-binding receptors
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-418594 G alpha (i) signalling events
R-HSA-416476 G alpha (q) signalling events
R-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-5620920 Cargo trafficking to the periciliary membrane
R-HSA-388396 GPCR downstream signalling
R-HSA-500792 GPCR ligand binding
R-HSA-5617833 Cilium Assembly
R-HSA-372790 Signaling by GPCR
R-HSA-1852241 Organelle biogenesis and maintenance
R-HSA-162582 Signal Transduction

-  Other Names for This Gene
  Alternate Gene Symbols: B2RBX6, ENST00000249016.1, ENST00000249016.2, ENST00000249016.3, ENST00000249016.4, GPR24, MCHR1 , MCHR1_HUMAN, NM_005297, Q5R3J1, Q96S47, Q99705, Q9BV08, SLC1, uc317eyq.1, uc317eyq.2
UCSC ID: ENST00000249016.5_6
RefSeq Accession: NM_005297.4
Protein: Q99705 (aka MCHR1_HUMAN or MCR1_HUMAN)

-  Gene Model Information
  Click here for a detailed description of the fields of the table above.

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.