ID:MBD3_HUMAN DESCRIPTION: RecName: Full=Methyl-CpG-binding domain protein 3; AltName: Full=Methyl-CpG-binding protein MBD3; FUNCTION: Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. SUBUNIT: Heterodimer with MBD2. Part of the NuRD and the MeCP1 complex. Binds HDAC1, MTA2, DNMT1, p66-alpha and p66-beta. INTERACTION: P17844:DDX5; NbExp=4; IntAct=EBI-1783068, EBI-351962; SUBCELLULAR LOCATION: Nucleus. Note=Nuclear, in discrete foci. SIMILARITY: Contains 1 MBD (methyl-CpG-binding) domain. SEQUENCE CAUTION: Sequence=AAH32443.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF01429 - Methyl-CpG binding domain PF14048 - C-terminal domain of methyl-CpG binding protein 2 and 3 PF16564 - p55-binding region of Methyl-CpG-binding domain proteins MBD
SCOP Domains: 48371 - ARM repeat 54171 - DNA-binding domain
ModBase Predicted Comparative 3D Structure on O95983
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003677 DNA binding GO:0003682 chromatin binding GO:0004407 histone deacetylase activity GO:0005515 protein binding GO:0008327 methyl-CpG binding GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0031492 nucleosomal DNA binding
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0001701 in utero embryonic development GO:0006346 methylation-dependent chromatin silencing GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0007420 brain development GO:0007507 heart development GO:0007568 aging GO:0009888 tissue development GO:0014070 response to organic cyclic compound GO:0016573 histone acetylation GO:0016575 histone deacetylation GO:0031667 response to nutrient levels GO:0032355 response to estradiol GO:0043044 ATP-dependent chromatin remodeling GO:0044030 regulation of DNA methylation GO:0048568 embryonic organ development
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
