ID:MAP7_HUMAN DESCRIPTION: RecName: Full=Ensconsin; AltName: Full=Epithelial microtubule-associated protein of 115 kDa; Short=E-MAP-115; AltName: Full=Microtubule-associated protein 7; Short=MAP-7; FUNCTION: Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments. SUBUNIT: Interacts with TRPV4 (By similarity). SUBCELLULAR LOCATION: Cytoplasm, perinuclear region. Basolateral cell membrane. Cytoplasm, cytoskeleton. Note=Colocalized on microtubules. An intracellular redistribution is triggered during induction of keratinocyte terminal differentiation from microtubules with a perinuclear localization to cortical microtubules organized in spike-like bundles facing intercellular contacts. TISSUE SPECIFICITY: Expressed in the skin and cells of epithelial origin. Predominantly expressed in the suprabasal layers of the normal epidermis and relatively abundant in squamous cell carcinomas but barely detectable in basal cell carcinomas. INDUCTION: Up-regulated upon terminal differentiation of primary keratinocytes. PTM: The association with microtubules is regulated by phosphorylation during the cell cycle. During interphase only phosphorylated on serine. Phosphorylated on threonine in mitosis. SIMILARITY: Belongs to the MAP7 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q14244
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000226 microtubule cytoskeleton organization GO:0006970 response to osmotic stress GO:0007163 establishment or maintenance of cell polarity GO:0072659 protein localization to plasma membrane
BC025777 - Homo sapiens microtubule-associated protein 7, mRNA (cDNA clone MGC:34092 IMAGE:5222987), complete cds. X73882 - H.sapiens E-MAP-115 mRNA. AK316529 - Homo sapiens cDNA, FLJ79428 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK299355 - Homo sapiens cDNA FLJ56145 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK294461 - Homo sapiens cDNA FLJ50486 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK296483 - Homo sapiens cDNA FLJ50557 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK295749 - Homo sapiens cDNA FLJ50537 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK316062 - Homo sapiens cDNA, FLJ78961 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK296556 - Homo sapiens cDNA FLJ50558 complete cds, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AJ242501 - Homo sapiens mRNA for E-MAP-115/95 (MAP gene). AJ242502 - Homo sapiens mRNA for E-MAP-115/105 (MAP gene). KJ897955 - Synthetic construct Homo sapiens clone ccsbBroadEn_07349 MAP7 gene, encodes complete protein. AB384694 - Synthetic construct DNA, clone: pF1KB1290, Homo sapiens MAP7 gene for microtubule-associated protein 7, complete cds, without stop codon, in Flexi system. DQ890946 - Synthetic construct clone IMAGE:100003576; FLH167861.01X; RZPDo839G0590D microtubule-associated protein 7 (MAP7) gene, encodes complete protein. DQ896812 - Synthetic construct Homo sapiens clone IMAGE:100011272; FLH167857.01L; RZPDo839G0589D microtubule-associated protein 7 (MAP7) gene, encodes complete protein. AK312789 - Homo sapiens cDNA, FLJ93207, highly similar to Homo sapiens microtubule-associated protein 7 (MAP7), mRNA. AK311114 - Homo sapiens cDNA, FLJ18156. CU693064 - Synthetic construct Homo sapiens gateway clone IMAGE:100017797 5' read MAP7 mRNA. AK307873 - Homo sapiens cDNA, FLJ97821. AK311236 - Homo sapiens cDNA, FLJ18278. AK311234 - Homo sapiens cDNA, FLJ18276. AK311227 - Homo sapiens cDNA, FLJ18269. AK311270 - Homo sapiens cDNA, FLJ18312. AJ420541 - Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 1075604. JD356756 - Sequence 337780 from Patent EP1572962. JD094484 - Sequence 75508 from Patent EP1572962. JD024988 - Sequence 6012 from Patent EP1572962. JD028129 - Sequence 9153 from Patent EP1572962. AB073649 - Homo sapiens primary neuroblastoma cDNA, clone:Nbla00172, full insert sequence.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
