ID:MAP6_HUMAN DESCRIPTION: RecName: Full=Microtubule-associated protein 6; Short=MAP-6; AltName: Full=Stable tubule-only polypeptide; Short=STOP; FUNCTION: Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. SUBUNIT: Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+) (By similarity). SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Golgi apparatus (By similarity). Note=Colocalizes with neurofilament (NF)-rich inclusions in spinal chord and brain neurons of patients with amyotrophic lateral sclerosis (ALS). TISSUE SPECIFICITY: Expressed in brain (at protein level). Expressed in spinal chord. Isoform 2 expression is up-regulated in the prefrontal cortex (Brodmann's area 46) of patients with schizophrenia (postmortem brain study). SIMILARITY: Belongs to the STOP family. SEQUENCE CAUTION: Sequence=AAH63860.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96JE9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
