ID:MP2K5_HUMAN DESCRIPTION: RecName: Full=Dual specificity mitogen-activated protein kinase kinase 5; Short=MAP kinase kinase 5; Short=MAPKK 5; EC=2.7.12.2; AltName: Full=MAPK/ERK kinase 5; Short=MEK 5; FUNCTION: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. SUBUNIT: Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ. INTERACTION: P62993:GRB2; NbExp=2; IntAct=EBI-307294, EBI-401755; Q13164:MAPK7; NbExp=2; IntAct=EBI-307294, EBI-1213983; TISSUE SPECIFICITY: Expressed in many adult tissues. Abundant in heart and skeletal muscle. DOMAIN: Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the OPR domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity). PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity). PTM: Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. SIMILARITY: Contains 1 OPR domain. SIMILARITY: Contains 1 protein kinase domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13163
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000122 negative regulation of transcription from RNA polymerase II promoter GO:0000165 MAPK cascade GO:0000187 activation of MAPK activity GO:0006468 protein phosphorylation GO:0007165 signal transduction GO:0007346 regulation of mitotic cell cycle GO:0007507 heart development GO:0016310 phosphorylation GO:0018108 peptidyl-tyrosine phosphorylation GO:0023014 signal transduction by protein phosphorylation GO:0030307 positive regulation of cell growth GO:0031098 stress-activated protein kinase signaling cascade GO:0032088 negative regulation of NF-kappaB transcription factor activity GO:0032147 activation of protein kinase activity GO:0034115 negative regulation of heterotypic cell-cell adhesion GO:0042981 regulation of apoptotic process GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045415 negative regulation of interleukin-8 biosynthetic process GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0050679 positive regulation of epithelial cell proliferation GO:0051247 positive regulation of protein metabolic process GO:0060761 negative regulation of response to cytokine stimulus GO:0070375 ERK5 cascade GO:0071363 cellular response to growth factor stimulus GO:0071499 cellular response to laminar fluid shear stress GO:0090051 negative regulation of cell migration involved in sprouting angiogenesis GO:2000342 negative regulation of chemokine (C-X-C motif) ligand 2 production GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
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Common Gene Haplotype Alleles 
